SR 13800
Tocris Bioscience, part of Bio-Techne | Catalog # 5431
Potent MCT1 inhibitor
Key Product Details
Description
Potent MCT1 inhibitor
Product Description
SR 13800 is a potent MCT1 inhibitor (IC50 = 0.5 nM); blocks proliferation of Raji lymphoma cells in vitro. Also inhibits lactate uptake in breast cancer cells in vitro.Product Specifications
Molecular Weight
435.58
Formula
C25H29N3O2S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
2,6-Dihydro-7-[(3-hydroxypropyl)thio]-2-methyl-4-(2-methylpropyl)-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyridazin-1one
CAS Number
227321-12-2
PubChem ID
5282542
InChI Key
VDAVMXLEMHVXOG-UHFFFAOYSA-N
SMILES
O=C1N(C)N=C(CC(C)C)C2=CN(CC3=C(C=CC=C4)C4=CC=C3)C(SCCCO)=C12
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.56 | 100 | |
| Ethanol | 8.71 | 20 |
Preparing Stock Solutions
for SR 13800
The following data is based on the product molecular weight 435.58
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.30 mL | 11.48 mL | 22.96 mL |
| 5 mM | 0.46 mL | 2.30 mL | 4.59 mL |
| 10 mM | 0.23 mL | 1.15 mL | 2.30 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Wang Synthesis and structure-activity relationships of pteridine dione and trione monocarboxylate transporter 1 inhibitors. J.Med.Chem. 2014 PMID: 25068893
- Murray Monocarboxylate transporter MCT1 is a target for immunosuppression. Nat.Chem.Biol. 2005 PMID: 16370372
Product Specific Notices for SR 13800
For research use only
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