SR 13800

Name: SR 13800
Brand: Tocris Bioscience
SKU: 5431

Tocris Bioscience a Bio-Techne Brand

Catalog # 5431

Citations (2)

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Key Product Details

Description:	Potent MCT1 inhibitor
Chemical Name:	2,6-Dihydro-7-[(3-hydroxypropyl)thio]-2-methyl-4-(2-methylpropyl)-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyridazin-1one
Purity:	≥98% (HPLC)
Molecular Weight:	435.58

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Biological Activity for SR 13800

SR 13800 is a potent MCT1 inhibitor (IC₅₀ = 0.5 nM); blocks proliferation of Raji lymphoma cells in vitro. Also inhibits lactate uptake in breast cancer cells in vitro.

Technical Data for SR 13800

M. Wt	435.58
Formula	C₂₅H₂₉N₃O₂S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	227321-12-2
PubChem ID	5282542
InChi Key	VDAVMXLEMHVXOG-UHFFFAOYSA-N
Smiles	O=C1N(C)N=C(CC(C)C)C2=CN(CC3=C(C=CC=C4)C4=CC=C3)C(SCCCO)=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SR 13800

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	43.56	100
	ethanol	8.71	20

Preparing Stock Solutions for SR 13800

The following data is based on the product molecular weight 435.58.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.30 mL	11.48 mL	22.96 mL
5 mM	0.46 mL	2.30 mL	4.59 mL
10 mM	0.23 mL	1.15 mL	2.30 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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References for SR 13800

References are publications that support the biological activity of the product.

Wang Synthesis and structure-activity relationships of pteridine dione and trione monocarboxylate transporter 1 inhibitors. J.Med.Chem. 2014 PMID: 25068893
Murray Monocarboxylate transporter MCT1 is a target for immunosuppression. Nat.Chem.Biol. 2005 PMID: 16370372

Citations for SR 13800 (2)

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Citations are publications that use Bio-Techne products. Selected citations for SR 13800 include:

Maacha et al. (2018) AXL Mediates Esophageal Adenocarcinoma Cell Invasion through Regulation of Extracellular Acidification and Lysosome Trafficking. Neoplasia. 20:1008
PMID: 30189359
Liu et al. (2017) The Glia-Neuron Lactate Shuttle and Elevated ROS Promote Lipid Synthesis in Neurons and Lipid Droplet Accumulation in Glia via APOE/D. Cell Metab. 26:719
PMID: 28965825

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