IGFBP-3 Products
IGFBP-3 (Insulin-like growth factor binding protein-3) modulates the biological activity of IGF. It circulates in a ternary complex with IGF and the acid-labile subunit (ALS). Proteolysis of IGFBP-3 by tissue plasminogen activator (tPA), a disintegrin and metalloproteases (ADAMs), and prostate specific antigen (PSA) contributes to IGFBP-3 degradation or a reduction in its affinity for IGF. The majority of soluble IGFBP-3 found in circulation is secreted from hepatic non-parenchymal cells. IGFBP-3 potentiates EGF-EGFR-mediated cell growth, modulates adipogenesis, and regulates TGF-beta signaling, DNA damage, apoptosis, autophagy, and gene transcription.
302 results for "IGFBP-3" in Products
302 results for "IGFBP-3" in Products
IGFBP-3 Products
IGFBP-3 (Insulin-like growth factor binding protein-3) modulates the biological activity of IGF. It circulates in a ternary complex with IGF and the acid-labile subunit (ALS). Proteolysis of IGFBP-3 by tissue plasminogen activator (tPA), a disintegrin and metalloproteases (ADAMs), and prostate specific antigen (PSA) contributes to IGFBP-3 degradation or a reduction in its affinity for IGF. The majority of soluble IGFBP-3 found in circulation is secreted from hepatic non-parenchymal cells. IGFBP-3 potentiates EGF-EGFR-mediated cell growth, modulates adipogenesis, and regulates TGF-beta signaling, DNA damage, apoptosis, autophagy, and gene transcription.
| Reactivity: | Human |
| Details: | Mouse IgG2b Kappa Monoclonal Clone #IGFBP3/3423 |
| Applications: | IHC |
![IGFBP-3 Antibody (IGFBP3/3423) - Azide and BSA Free Immunohistochemistry-Paraffin: IGFBP-3 Antibody (IGFBP3/3423) - Azide and BSA Free [NBP3-24250] -](https://resources.bio-techne.com/images/products/nbp3-24250_mouse-igfbp-3-mab-igfbp3-3423-azide-and-bsa-free-2412025801662.jpg "Immunohistochemistry-Paraffin: IGFBP-3 Antibody (IGFBP3/3423) - Azide and BSA Free [NBP3-24250] -")
| Reactivity: | Human |
| Details: | Mouse IgG2b Kappa Monoclonal Clone #IGFBP3/3423 |
| Applications: | IHC |
![IGFBP-3 Antibody (IGFBP3/3423) Protein Array: IGFBP-3 Antibody (IGFBP3/3423) [NBP3-23802] -](https://resources.bio-techne.com/images/products/nbp3-23802_mouse-igfbp-3-mab-igfbp3-3423-241202587488.jpg "Protein Array: IGFBP-3 Antibody (IGFBP3/3423) [NBP3-23802] -")
| Reactivity: | Human |
| Details: | Mouse IgG2b Kappa Monoclonal Clone #IGFBP3/3423 |
| Applications: | IHC |
| Reactivity: | Human |
| Details: | Mouse IgG2b Kappa Monoclonal Clone #IGFBP3/3423 |
| Applications: | IHC |
| Reactivity: | Human |
| Details: | Mouse IgG2b Kappa Monoclonal Clone #IGFBP3/3423 |
| Applications: | IHC |
| Reactivity: | Human |
| Details: | Mouse IgG2b Kappa Monoclonal Clone #IGFBP3/3423 |
| Applications: | IHC |
| Reactivity: | Human |
| Details: | Mouse IgG2b Kappa Monoclonal Clone #IGFBP3/3423 |
| Applications: | IHC |
| Reactivity: | Human |
| Details: | Mouse IgG2b Kappa Monoclonal Clone #IGFBP3/3423 |
| Applications: | IHC |
| Reactivity: | Human |
| Details: | Mouse IgG2b Kappa Monoclonal Clone #IGFBP3/3423 |
| Applications: | IHC |
| Reactivity: | Human |
| Details: | Mouse IgG2b Kappa Monoclonal Clone #IGFBP3/3423 |
| Applications: | IHC |
| Sensitivity: | 0.14 ng/mL |
| Applications: | ELISA |
| Assay Range: | 0.781 - 50 ng/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma) |
| Source: | NS0 |
| Accession #: | CAA46087 |
| Applications: | BA |
| Sensitivity: | 16 pg/mL |
| Applications: | ELISA |
| Assay Range: | 78.1 - 5,000 pg/mL (Cell Culture Supernates, EDTA Plasma) |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, IHC, Neut |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #84728 |
| Applications: | WB, IHC |
| Assay Range: | 125 - 8,000 pg/mL |
| Applications: | ELISA |
| Source: | NS0 |
| Accession #: | CAA57271.1 |
| Applications: | BA |
| Chemical Name: | 1-(3,4-Dihydroxybenzoyl)-6,7-dihydroxy-3-isoquinolinecarboxylic acid |
| Purity: | ≥98% (HPLC) |
