NBI 31772

Name: NBI 31772
Brand: Tocris Bioscience
SKU: 5192

Tocris Bioscience a Bio-Techne Brand

Catalog # 5192

Citations (1)

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Key Product Details

Description:	High affinity insulin-like growth factor-I binding protein IGFBP inhibitor
Chemical Name:	1-(3,4-Dihydroxybenzoyl)-6,7-dihydroxy-3-isoquinolinecarboxylic acid
Purity:	≥98% (HPLC)
Molecular Weight:	341.27

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Biological Activity for NBI 31772

NBI 31772 is a high affinity insulin-like growth factor-1 binding protein (IGFBP) inhibitor (K_i values are 1 - 24 nM for all six human subtypes). Displaces insulin-like growth factor-1 (IGF-1) from the IGF-1:IGFBP complex and suppresses IGF1-induced proliferation of 3T3 fibroblasts. Also increases cardiomyocyte proliferation in vivo.

Technical Data for NBI 31772

M. Wt	341.27
Formula	C₁₇H₁₁NO₇
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	374620-70-9
PubChem ID	54684689
InChi Key	QUIWTBSOEFPLHE-FOCLMDBBSA-N
Smiles	O=C(C3=CC=C(O)C(O)=C3)C2=NC(C(O)=O)=CC1=CC(O)=C(O)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NBI 31772

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	34.13	100

Preparing Stock Solutions for NBI 31772

The following data is based on the product molecular weight 341.27.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.93 mL	14.65 mL	29.30 mL
5 mM	0.59 mL	2.93 mL	5.86 mL
10 mM	0.29 mL	1.47 mL	2.93 mL
50 mM	0.06 mL	0.29 mL	0.59 mL

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References for NBI 31772

References are publications that support the biological activity of the product.

Choi In vivo monitoring of cardiomyocyte proliferation to identify chemical modifiers of heart regeneration. Development. 2013 PMID: 23293297
Chen Discovery of a series of nonpeptide small molecules that inhibit the binding of Ins-like growth factor (IGF) to IGF-binding proteins. J.Med.Chem. 2001 PMID: 11689087

Citations for NBI 31772 (1)

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Citations are publications that use Bio-Techne products. Selected citations for NBI 31772 include:

Ichijo et al. (2017) Tbx3-dependent amplifying stem cell progeny drives interfollicular epidermal expansion during pregnancy and regeneration. Nat Commun. 8:508
PMID: 28894084

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Product Documents for NBI 31772

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.