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HIF-1 alpha/HIF1A Products
The hypoxia-inducible transcription factor 1 alpha (HIF-1 alpha/HIF1A) is the regulated member of the transcription factor heterodimer HIF-1 alpha/beta. HIF-1 alpha/HIF1A binds to hypoxia-response elements (HREs) in the promoters of many genes involved in the adaptation to an environment of insufficient oxygen or hypoxia. Hypoxic tissue environments occur in vascular and pulmonary diseases as well as cancer, which illustrates the broad impact of gene regulation by HIF1A.
36 results for "HIF-1 alpha/HIF1A" in Products
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HIF-1 alpha/HIF1A Products
The hypoxia-inducible transcription factor 1 alpha (HIF-1 alpha/HIF1A) is the regulated member of the transcription factor heterodimer HIF-1 alpha/beta. HIF-1 alpha/HIF1A binds to hypoxia-response elements (HREs) in the promoters of many genes involved in the adaptation to an environment of insufficient oxygen or hypoxia. Hypoxic tissue environments occur in vascular and pulmonary diseases as well as cancer, which illustrates the broad impact of gene regulation by HIF1A.
36 results for "HIF-1 alpha/HIF1A" in Products
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #241809 |
| Applications : | Immunohistochemistry, Immunoprecipitation, Knockout Validated, Simple Western, Western Blot |
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | Chromatin Immunoprecipitation, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Knockout Validated, Simple Western, Western Blot |
Contains 4 membranes - each spotted in duplicate with 35 different apoptosis antibodies
Highly potent and selective HIF-1α inhibitor
| Alternate Names : | Quinomycin A |
| Chemical Name : | N-(2-Quinoxalinylcarbonyl)-O-[N-(2-quinoxalinylcarbonyl)-D-seryl-L-alanyl-3-mercapto-N,S-dimethylcysteinyl-N-methyl-L-valyl]-D-seryl-L-alanyl-N-methylcysteinyl-N-methyl-L-valine-(81)-lactone-cyclic (37)-thioether |
| Purity : | ≥98% (HPLC) |
Contains 4 membranes - each spotted in duplicate with 26 different cell stress antibodies
Contains 4 membranes-each spotted in duplicate with 84 different cancer-related antibodies
Contains 4 membranes-each spotted in duplicate with 49 different antibodies to ubiquitin target proteins
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #241812 |
| Applications : | Flow Cytometry |
Contains 8 membranes - each spotted in duplicate with 21 different apoptosis antibodies
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #241812 |
| Applications : | CyTOF-ready, Flow Cytometry, Immunohistochemistry |
| Assay Range : | 125 - 8,000 pg/mL |
| Applications : | ELISA |
Recombinant Monoclonal Antibody.
| Clonality : | Monoclonal |
| Host : | Rabbit IgG1 Clone #2443B |
| Applications : | Immunocytochemistry/Immunofluorescence, Knockout Validated, Simple Western, Western Blot |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #241812 |
| Applications : | Flow Cytometry |
Thioredoxin-1 inhibitor
| Alternate Names : | IV-2 |
| Chemical Name : | 2-[(1-Methylpropyl)dithio]-1H-imidazole |
| Purity : | ≥99% (HPLC) |
HIF-1α inhibitor; down-regulates HIF-1α protein synthesis
| Chemical Name : | N,N'-(Dithiodi-2,1-ethanediyl)bis[2,5-dichlorobenzenesulfonamide |
| Purity : | ≥98% (HPLC) |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #241812 |
| Applications : | Flow Cytometry |
Prolyl hydroxylase inhibitor
| Chemical Name : | N-(2-Methoxy-2-oxoacetyl)glycine methyl ester |
| Purity : | ≥97% |
Mitochondrial complex I inhibitor
| Chemical Name : | 1-Cyclopropyl-4-[4-[[5-methyl-3-[3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]-1H-pyrazol-1-yl]methyl]-2-pyridinyl]piperazine |
| Purity : | ≥98% (HPLC) |
Fluorescent HIF-1α peptide; can be used to evaluate the effect of VHL binding on degradation activity
| Purity : | ≥95% (HPLC) |
Potent, selective HIF-1α prolyl hydroxylase-2 (PHD2) inhibitor
| Chemical Name : | N-[[1,2-Dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]glycine |
| Purity : | ≥99% (HPLC) |
Malate dehydrogenase-2 (MDH2) inhibitor; also inhibits HIF-1α
| Alternate Names : | CAY 10585 |
| Chemical Name : | Methyl 4-hydroxy-3-[[2-(4-tricyclo[3.3.1.13,7]dec-1-ylphenoxy)acetyl]amino]benzoate |
| Purity : | ≥98% (HPLC) |
HIF α-subunit inhibitor
| Chemical Name : | 2-Oxo-2-(p-tolyl)ethyl 3-(2,4-dinitrobenzamido)benzoate |
| Purity : | ≥98% (HPLC) |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #241812 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #241812 |
| Applications : | Flow Cytometry |
