DMOG

Name: DMOG
Brand: Tocris Bioscience
SKU: 4408
Rating: 5 (2 reviews)

Catalog # 4408 | Tocris Bioscience a Bio-Techne Brand

(2)

Citations (3)

COA / SDS

Prolyl hydroxylase inhibitor

Key Product Details

Description:	Prolyl hydroxylase inhibitor
Chemical Name:	N-(2-Methoxy-2-oxoacetyl)glycine methyl ester
Purity:	≥97% (HPLC)
Molecular Weight:	175.14

View Full Technical Details for DMOG

Biological Activity for DMOG

DMOG is a prolyl 4-hydroxylase (P4H) inhibitor; inhibits hypoxia-inducible factor α (HIF-α) prolyl hydroxylase (HIF-PH). Increases levels of HIF-1α; promotes cell survival under hypoxic conditions. Inhibits differentiation of hematopoietic stem cells (HSCs) in culture.

Technical Data for DMOG

M. Wt	175.14
Formula	C₆H₉NO₅
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	89464-63-1
PubChem ID	560326
InChi Key	BNJOZDZCRHCODO-UHFFFAOYSA-N
Smiles	O=C(C(OC)=O)NCC(OC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for DMOG

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	17.51	100
	DMSO	17.51	100

Preparing Stock Solutions for DMOG

The following data is based on the product molecular weight 175.14.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.71 mL	28.55 mL	57.10 mL
5 mM	1.14 mL	5.71 mL	11.42 mL
10 mM	0.57 mL	2.85 mL	5.71 mL
50 mM	0.11 mL	0.57 mL	1.14 mL

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Reconstitution Calculator

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References for DMOG

References are publications that support the biological activity of the product.

Jackson Targeting the aryl hydrocarbon receptor nuclear translocator complex with DMOG and Stemregenin 1 improves primitive hematopoietic stem cell expansion. Stem Cell Res 2017 PMID: 28445828
Barnucz Prolyl-hydroxylase inhibition preserves endothelial cell function in a rat model of vascular ischemia reperfusion injury. J.Pharmacol.Exp.Ther. 2013 PMID: 23388095
Ayrapetov Activation of Hif1α by the prolylhydroxylase inhibitor dimethyoxalyglycine decreases radiosensitivity. PLoS One 2011 PMID: 22016813
Lomb Prolyl hydroxylase inhibitors depend on extracellular glucose and hypoxia-inducible factor (HIF)-2α to inhibit cell death caused by nerve growth factor (NGF) deprivation: evidence that HIF-2α has a role in NGF-promoted survival of sympathetic ne Mol.Pharmacol. 2009 PMID: 19204094
Jaakkola Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O₂-regulated prolyl hydroxylation. Science 2001 PMID: 11292861

Citations for DMOG (3)

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Citations are publications that use Bio-Techne products. Selected citations for DMOG include:

Wiktoria et al. (2022) Autoregulation of H+/lactate efflux prevents monocarboxylate transport (MCT) inhibitors from reducing glycolytic lactic acid production. Br J Cancer. 127:1365-1377
PMID: 35840734
Izzie Jacques et al. (2022) Hypoxia-mediated stabilization of HIF1A in prostatic intraepithelial neoplasia promotes cell plasticity and malignant progression. Sci Adv. 8:eabo2295
PMID: 35867798
Banh et al. (2016) PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia. Nat Cell Biol. 18:803
PMID: 27323329

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Customer Reviews for DMOG (2)

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DMOG

Name: shubham dubey

Species: Human

Assay Type: In Vitro

Cell Line/Tissue: A549

IN cell culture to stabilize HIF1
Good product

Name: P Kumar

Species: Human

Assay Type: In Vitro

Cell Line/Tissue: A549

To check the HIF2a activity in A549 cells.

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Product Documents for DMOG

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

DMOG

Catalog # 4408 | Tocris Bioscience a Bio-Techne Brand

Key Product Details

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Biological Activity for DMOG

Technical Data for DMOG

Solubility for DMOG

Preparing Stock Solutions for DMOG

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for DMOG

Citations for DMOG (3)

Customer Reviews for DMOG (2)

Customer Images

DMOG

Good product

Product Documents for DMOG

COA

Certificate of Analysis

SDS

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