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GITR Ligand/TNFSF18 Products

GITR Ligand, also known as TNFSF18 and TL6, is a transmembrane glycoprotein that is expressed on antigen presenting cells, CD4-CD8- double negative thymic precursors, vascular endothelial cells, neurons, and in the eye. Its expression is transiently upregulated by proinflammatory stimulation. The binding of GITR Ligand to GITR on mouse CD25+ Treg cells permits the reactivation of T cells from Treg-induced suppression. GITR Ligand binding to GITR additionally provides a costimulatory signal to activated CD4+  and CD8+ T cells and NK cells. This interaction also induces reverse signaling in GITR Ligand expressing dendritic cells to suppress cellular activation through the same pathway induced by the immunosuppressant dexamethasone. In the brain, GITR Ligand/GITR interactions enhance NGF-mediated neurite outgrowth from sympathetic neurons.

50 results for "GITR Ligand/TNFSF18" in Products

GITR Ligand/TNFSF18 Products

GITR Ligand, also known as TNFSF18 and TL6, is a transmembrane glycoprotein that is expressed on antigen presenting cells, CD4-CD8- double negative thymic precursors, vascular endothelial cells, neurons, and in the eye. Its expression is transiently upregulated by proinflammatory stimulation. The binding of GITR Ligand to GITR on mouse CD25+ Treg cells permits the reactivation of T cells from Treg-induced suppression. GITR Ligand binding to GITR additionally provides a costimulatory signal to activated CD4+  and CD8+ T cells and NK cells. This interaction also induces reverse signaling in GITR Ligand expressing dendritic cells to suppress cellular activation through the same pathway induced by the immunosuppressant dexamethasone. In the brain, GITR Ligand/GITR interactions enhance NGF-mediated neurite outgrowth from sympathetic neurons.

50 results for "GITR Ligand/TNFSF18" in Products

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TNFSF18 (GCN4-IZ) (CHO-expressed)

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A New and Improved rh GITR-L is Available! CHO expressed; ~70 fold better activity; HA tag!

Flow, Block, CyTOF-ready
BA

TNFSF18 (GCN4-IZ) (CHO-expressed)

Flow, Block, CyTOF-ready
BA
WB, Flow, Block, CyTOF-ready
Flow
BA
Catalog #: FAB6941R
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Catalog #: FAB6942V
Flow
Flow
Catalog #: FAB21773T
Flow
Catalog #: FAB21773R
Flow
Catalog #: FAB6942U
Flow
Catalog #: FAB21773U
Flow
Catalog #: FAB6942N
Flow
Catalog #: FAB21774N
Flow
Flow, CyTOF-ready, Neut
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