Sign In / Register
GITR Ligand/TNFSF18 Products
GITR Ligand, also known as TNFSF18 and TL6, is a transmembrane glycoprotein that is expressed on antigen presenting cells, CD4-CD8- double negative thymic precursors, vascular endothelial cells, neurons, and in the eye. Its expression is transiently upregulated by proinflammatory stimulation. The binding of GITR Ligand to GITR on mouse CD25+ Treg cells permits the reactivation of T cells from Treg-induced suppression. GITR Ligand binding to GITR additionally provides a costimulatory signal to activated CD4+ and CD8+ T cells and NK cells. This interaction also induces reverse signaling in GITR Ligand expressing dendritic cells to suppress cellular activation through the same pathway induced by the immunosuppressant dexamethasone. In the brain, GITR Ligand/GITR interactions enhance NGF-mediated neurite outgrowth from sympathetic neurons.
50 results for "GITR Ligand/TNFSF18" in Products
Application
Conjugates
Clonality
Host Species
Isotype
Clone
Low Endotoxin
Sample Size
Citations
Reviews
GITR Ligand/TNFSF18 Products
GITR Ligand, also known as TNFSF18 and TL6, is a transmembrane glycoprotein that is expressed on antigen presenting cells, CD4-CD8- double negative thymic precursors, vascular endothelial cells, neurons, and in the eye. Its expression is transiently upregulated by proinflammatory stimulation. The binding of GITR Ligand to GITR on mouse CD25+ Treg cells permits the reactivation of T cells from Treg-induced suppression. GITR Ligand binding to GITR additionally provides a costimulatory signal to activated CD4+ and CD8+ T cells and NK cells. This interaction also induces reverse signaling in GITR Ligand expressing dendritic cells to suppress cellular activation through the same pathway induced by the immunosuppressant dexamethasone. In the brain, GITR Ligand/GITR interactions enhance NGF-mediated neurite outgrowth from sympathetic neurons.
50 results for "GITR Ligand/TNFSF18" in Products
Catalog #:
AFR6987
BA
TNFSF18 (GCN4-IZ) (CHO-expressed)
| Source : | CHO |
| Accession # : | Q9UNG2.3 |
| Applications : | Bioactivity |
Catalog #:
694-GL
Bind
A New and Improved rh GITR-L is Available! CHO expressed; ~70 fold better activity; HA tag!
| Source : | Sf 21 (baculovirus) |
| Accession # : | Q9UNG2 |
| Applications : | Binding Activity |
WB
| Clonality : | Monoclonal |
| Host : | Rat IgG1 Clone #721926 |
| Applications : | Western Blot |
BA
| Source : | CHO |
| Accession # : | Q9UNG2.3 |
| Applications : | Bioactivity |
Catalog #:
BAM6943
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #109117 |
| Applications : | ELISA Detection |
Catalog #:
MAB6942
Flow, Block, CyTOF-ready
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #109114 |
| Applications : | Block/Neutralize, CyTOF-ready, ELISA Capture, Flow Cytometry |
ELISA
| Assay Range : | 125 - 8,000 pg/mL |
| Applications : | ELISA |
Catalog #:
AFG6987
BA
TNFSF18 (GCN4-IZ) (CHO-expressed)
| Source : | CHO |
| Accession # : | Q9UNG2.3 |
| Applications : | Bioactivity |
Catalog #:
MAB6941
Flow, Block, CyTOF-ready
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #109101 |
| Applications : | Block/Neutralize, CyTOF-ready, Flow Cytometry |
Neut
| Clonality : | Monoclonal |
| Host : | Rat IgG2a Clone #337122 |
| Applications : | Block/Neutralize, ELISA Capture |
Catalog #:
9735-GL
BA
| Source : | NS0 |
| Accession # : | XP_008767927 |
| Applications : | Bioactivity |
Catalog #:
AF694
WB, Flow, Block, CyTOF-ready
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | Block/Neutralize, CyTOF-ready, Flow Cytometry, Western Blot |
Catalog #:
FAB6941A
Flow
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #109101 |
| Applications : | Flow Cytometry |
Catalog #:
2177-GL
BA
| Source : | NS0 |
| Accession # : | AAO89011 |
| Applications : | Bioactivity |
Catalog #:
FAB6941R
Flow
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #109101 |
| Applications : | Flow Cytometry |
Catalog #:
FAB6942V
Flow
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #109114 |
| Applications : | Flow Cytometry |
Catalog #:
FAB6941N
Flow
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #109101 |
| Applications : | Flow Cytometry |
Flow
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #109101 |
| Applications : | Flow Cytometry |
Catalog #:
FAB21773T
Flow
| Clonality : | Monoclonal |
| Host : | Rat IgG1 Clone #994529 |
| Applications : | Flow Cytometry |
Catalog #:
FAB21773R
Flow
| Clonality : | Monoclonal |
| Host : | Rat IgG1 Clone #994529 |
| Applications : | Flow Cytometry |
Catalog #:
FAB6942U
Flow
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #109114 |
| Applications : | Flow Cytometry |
Catalog #:
FAB21773U
Flow
| Clonality : | Monoclonal |
| Host : | Rat IgG1 Clone #994529 |
| Applications : | Flow Cytometry |
Catalog #:
FAB6942N
Flow
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #109114 |
| Applications : | Flow Cytometry |
Catalog #:
FAB21774N
Flow
| Clonality : | Monoclonal |
| Host : | Rat IgG1 Clone #994572 |
| Applications : | Flow Cytometry |
Catalog #:
MAB21773
Flow, CyTOF-ready, Neut
| Clonality : | Monoclonal |
| Host : | Rat IgG1 Clone #994529 |
| Applications : | Block/Neutralize, CyTOF-ready, Flow Cytometry |
