
GITR Ligand/TNFSF18: Antibodies
GITR Ligand, also known as TNFSF18 and TL6, is a transmembrane glycoprotein that is expressed on antigen presenting cells, CD4-CD8- double negative thymic precursors, vascular endothelial cells, neurons, and in the eye. Its expression is transiently upregulated by proinflammatory stimulation. The binding of GITR Ligand to GITR on mouse CD25+ Treg cells permits the reactivation of T cells from Treg-induced suppression. GITR Ligand binding to GITR additionally provides a costimulatory signal to activated CD4+ and CD8+ T cells and NK cells. This interaction also induces reverse signaling in GITR Ligand expressing dendritic cells to suppress cellular activation through the same pathway induced by the immunosuppressant dexamethasone. In the brain, GITR Ligand/GITR interactions enhance NGF-mediated neurite outgrowth from sympathetic neurons.
43 results for "GITR Ligand/TNFSF18 Primary Antibodies" in Products
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GITR Ligand/TNFSF18: Antibodies
GITR Ligand, also known as TNFSF18 and TL6, is a transmembrane glycoprotein that is expressed on antigen presenting cells, CD4-CD8- double negative thymic precursors, vascular endothelial cells, neurons, and in the eye. Its expression is transiently upregulated by proinflammatory stimulation. The binding of GITR Ligand to GITR on mouse CD25+ Treg cells permits the reactivation of T cells from Treg-induced suppression. GITR Ligand binding to GITR additionally provides a costimulatory signal to activated CD4+ and CD8+ T cells and NK cells. This interaction also induces reverse signaling in GITR Ligand expressing dendritic cells to suppress cellular activation through the same pathway induced by the immunosuppressant dexamethasone. In the brain, GITR Ligand/GITR interactions enhance NGF-mediated neurite outgrowth from sympathetic neurons.
43 results for "GITR Ligand/TNFSF18 Primary Antibodies" in Products
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #109114 |
Applications : | Block/Neutralize, CyTOF-ready, ELISA Capture, Flow Cytometry |
Clone 296902 was used by HLDA to establish CD designation
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #296902 |
Applications : | CyTOF-ready, Flow Cytometry, Western Blot |
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #109101 |
Applications : | Block/Neutralize, CyTOF-ready, Flow Cytometry |
Clonality : | Monoclonal |
Host : | Rat IgG2a Clone #337122 |
Applications : | Block/Neutralize, ELISA Capture |
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #109117 |
Applications : | ELISA Detection |
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | Block/Neutralize, CyTOF-ready, Flow Cytometry, Western Blot |
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #109101 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Rat IgG1 Clone #721926 |
Applications : | Western Blot |
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #109101 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #109114 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #109101 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #109101 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #109114 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Rat IgG1 Clone #994529 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Rat IgG1 Clone #994529 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Rat IgG1 Clone #994529 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #109114 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Rat IgG1 Clone #994572 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Rat IgG1 Clone #994529 |
Applications : | Block/Neutralize, CyTOF-ready, Flow Cytometry |
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | ELISA Detection |
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | Flow Cytometry, Western Blot |
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #109101 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #109114 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Rat IgG1 Clone #994572 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #109114 |
Applications : | Flow Cytometry |