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GITR Ligand/TNFSF18: Antibodies

GITR Ligand, also known as TNFSF18 and TL6, is a transmembrane glycoprotein that is expressed on antigen presenting cells, CD4-CD8- double negative thymic precursors, vascular endothelial cells, neurons, and in the eye. Its expression is transiently upregulated by proinflammatory stimulation. The binding of GITR Ligand to GITR on mouse CD25+ Treg cells permits the reactivation of T cells from Treg-induced suppression. GITR Ligand binding to GITR additionally provides a costimulatory signal to activated CD4+  and CD8+ T cells and NK cells. This interaction also induces reverse signaling in GITR Ligand expressing dendritic cells to suppress cellular activation through the same pathway induced by the immunosuppressant dexamethasone. In the brain, GITR Ligand/GITR interactions enhance NGF-mediated neurite outgrowth from sympathetic neurons.

43 results for "GITR Ligand/TNFSF18 Primary Antibodies" in Products

GITR Ligand/TNFSF18: Antibodies

GITR Ligand, also known as TNFSF18 and TL6, is a transmembrane glycoprotein that is expressed on antigen presenting cells, CD4-CD8- double negative thymic precursors, vascular endothelial cells, neurons, and in the eye. Its expression is transiently upregulated by proinflammatory stimulation. The binding of GITR Ligand to GITR on mouse CD25+ Treg cells permits the reactivation of T cells from Treg-induced suppression. GITR Ligand binding to GITR additionally provides a costimulatory signal to activated CD4+  and CD8+ T cells and NK cells. This interaction also induces reverse signaling in GITR Ligand expressing dendritic cells to suppress cellular activation through the same pathway induced by the immunosuppressant dexamethasone. In the brain, GITR Ligand/GITR interactions enhance NGF-mediated neurite outgrowth from sympathetic neurons.

43 results for "GITR Ligand/TNFSF18 Primary Antibodies" in Products

Flow, Block, CyTOF-ready
WB, Flow, CyTOF-ready

Clone 296902 was used by HLDA to establish CD designation

Flow, Block, CyTOF-ready
WB, Flow, Block, CyTOF-ready
Flow
Catalog #: FAB6941R
Flow
Catalog #: FAB6942V
Flow
Flow
Catalog #: FAB6942N
Flow
Catalog #: FAB21773R
Flow
Catalog #: FAB21773T
Flow
Catalog #: FAB21773U
Flow
Catalog #: FAB6942U
Flow
Catalog #: FAB21774N
Flow
Flow, CyTOF-ready, Neut
Catalog #: BAF694
WB, Flow
Flow
Catalog #: FAB6942G
Flow
Catalog #: FAB21774G
Flow
Catalog #: FAB6942R
Flow
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