DPPIV/CD26: Small Molecules and Peptides
DPPIV/CD26 is a serine exopeptidase that is expressed as a noncovalent homodimer on the surface of epithelial cells, endothelial cells, and activated lymphocytes. It regulates multiple aspects of immune and endocrine function by cleaving Xaa-Pro or Xaa-Ala dipeptides from the N-terminus of a wide variety of chemokines (CCL4 and 5, CXCL6, 9, 10, 11, and 12), growth factors (GM-CSF, IL-3), and peptide hormones (Glucagon, Glucagon-like Peptides 1 and 2, GIP, GHRH, Procalcitonin, Neuropeptide Y, and Substance P).
DPPIV interacts in cis with Adenosine Deaminase on T cells, in trans with Caveolin-1 on antigen presenting cells, and it serves as a cell entry coreceptor for HIV and coronavirus. It provides costimulatory proliferation and activation signals to both CD4+ and CD8+ T cells. A soluble form of DPPIV can be proteolytically shed from adipocytes, leading to insulin resistance in adipocytes and skeletal muscle.
Products:
5 results for "DPPIV/CD26 Small Molecules and Peptides" in Products
5 results for "DPPIV/CD26 Small Molecules and Peptides" in Products
DPPIV/CD26: Small Molecules and Peptides
DPPIV/CD26 is a serine exopeptidase that is expressed as a noncovalent homodimer on the surface of epithelial cells, endothelial cells, and activated lymphocytes. It regulates multiple aspects of immune and endocrine function by cleaving Xaa-Pro or Xaa-Ala dipeptides from the N-terminus of a wide variety of chemokines (CCL4 and 5, CXCL6, 9, 10, 11, and 12), growth factors (GM-CSF, IL-3), and peptide hormones (Glucagon, Glucagon-like Peptides 1 and 2, GIP, GHRH, Procalcitonin, Neuropeptide Y, and Substance P).
DPPIV interacts in cis with Adenosine Deaminase on T cells, in trans with Caveolin-1 on antigen presenting cells, and it serves as a cell entry coreceptor for HIV and coronavirus. It provides costimulatory proliferation and activation signals to both CD4+ and CD8+ T cells. A soluble form of DPPIV can be proteolytically shed from adipocytes, leading to insulin resistance in adipocytes and skeletal muscle.
Products:
Potent and selective DPP IV inhibitor
| Chemical Name: | (3R)-3-Amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-1-butanone phosphate |
| Purity: | ≥98% (HPLC) |
Dipeptidyl peptidase IV (DPP-IV) inhibitor
| Alternate Names: | Ile-Pro-Ile |
| Chemical Name: | L-Isoleucyl-L-prolyl-L-isoleucine |
| Purity: | ≥98% (HPLC) |
Potent DPP IV inhibitor; activates NLRP1b inflammasome
| Alternate Names: | Val-boroPro,BXCL 701 |
| Chemical Name: | B-[(2R)-1-[(2S)-2-Amino-3-methyl-1-oxobutyl]-2-pyrrolidinyl]boronic acid methanesulfonate |
| Purity: | ≥98% (HPLC) |
Dipeptidyl peptidase IV (DPP-IV) inhibitor
| Chemical Name: | 1-[[[(1-Hydroxymethyl)cyclopentyl]amino]acetyl]-2,5-cis-pyrrolidinedicarbonitrile hydrochloride |
| Purity: | ≥98% (HPLC) |
High affinity DPP-IV inhibitor; active in vivo
| Alternate Names: | BMS 477118 |
| Chemical Name: | (1S,3S,5S)-2-[(2S)-Amino(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile hydrochloride |
| Purity: | ≥98% (HPLC) |
