DPPI 1c hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 2783
Dipeptidyl peptidase IV (DPP-IV) inhibitor
Key Product Details
Description
Dipeptidyl peptidase IV (DPP-IV) inhibitor
Product Description
DPPI 1c hydrochloride is an inhibitor of dipeptidyl peptidase IV (DPP-IV) (IC50 = 104 nM) that displays selectivity over enzymes with DPP-like activity (IC50 > 30 μM). Increases plasma GLP-1 levels and improves glucose tolerance in diabetic mice following oral glucose challenge.Product Specifications
Molecular Weight
312.80
Formula
C14H20N4O2.HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
1-[[[(1-Hydroxymethyl)cyclopentyl]amino]acetyl]-2,5-cis-pyrrolidinedicarbonitrile hydrochloride
CAS Number
866396-70-5
PubChem ID
11381415
InChI Key
RHCWAHDCHQTNBR-IWKKHLOMSA-N
SMILES
O=C(CNC2(CO)CCCC2)N1[C@@H](C#N)CC[C@H]1C#N.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 15.64 | 50 | |
| DMSO | 31.28 | 100 |
Preparing Stock Solutions
for DPPI 1c hydrochloride
The following data is based on the product molecular weight 312.80
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.20 mL | 15.98 mL | 31.97 mL |
| 5 mM | 0.64 mL | 3.20 mL | 6.39 mL |
| 10 mM | 0.32 mL | 1.60 mL | 3.20 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.64 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Wright cis-2-5-dicyanopyrrolidine inhibitors of dipeptidyl peptidase IV: synthesis and in vitro, in vivo, and X-ray crystallographic characterization. J.Med.Chem. 2006 PMID: 16722626
Product Specific Notices for DPPI 1c hydrochloride
For research use only
Loading...
Loading...