Talabostat mesylate
Tocris Bioscience, part of Bio-Techne | Catalog # 3719
Potent DPP IV inhibitor; activates NLRP1b inflammasome
Key Product Details
Description
Potent DPP IV inhibitor; activates NLRP1b inflammasome
Alternative Names
Val-boroPro,BXCL 701
Product Description
Talabostat mesylate is a potent DPP IV inhibitor (IC50 values are <4, 4, 11, 310 and 560 nM at DPP4, DPP8, DPP9, DPP7 and FAP, respectively). Activates the inflammasome sensor protein NLRP1b and selectively triggers pyroptosis in monocytes and macrophages. Induces immune-mediated tumor regression in multiple mouse models of cancer. Orally bioavailable.Product Specifications
Molecular Weight
310.18
Formula
C9H19BN2O3.CH3SO3H
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
B-[(2R)-1-[(2S)-2-Amino-3-methyl-1-oxobutyl]-2-pyrrolidinyl]boronic acid methanesulfonate
CAS Number
150080-09-4
PubChem ID
11522448
InChI Key
OXYYOEIGQRXGPI-WSZWBAFRSA-N
SMILES
O=C([C@@H](N)C(C)C)N1CCC[C@H]1B(O)O.CS(O)(=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 31.02 | 100 | |
| DMSO | 15.51 | 50 |
Preparing Stock Solutions
for Talabostat mesylate
The following data is based on the product molecular weight 310.18
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.22 mL | 16.12 mL | 32.24 mL |
| 5 mM | 0.64 mL | 3.22 mL | 6.45 mL |
| 10 mM | 0.32 mL | 1.61 mL | 3.22 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.64 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Okondo Inhibition of Dpp8/9 activates the Nlrp1b inflammasome. Cell Chem.Biol. 2018 PMID: 29396289
- Okondo DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis. Nat.Chem.Biol. 2017 PMID: 27820798
Product Specific Notices for Talabostat mesylate
For research use only
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