Sitagliptin phosphate
Tocris Bioscience, part of Bio-Techne | Catalog # 6816
Potent and selective DPP IV inhibitor
Key Product Details
Description
Potent and selective DPP IV inhibitor
Product Description
Sitagliptin phosphate is a potent and selective DPP IV (DPP4) inhibitor (IC50 = 18 nM). Displays >2600-fold selectivity for DPP IV over other proline specific peptidases. Reduces blood glucose and increases GLP-1 levels after oral glucose tolerance test in normal and diet-induced obese mice.Product Specifications
Molecular Weight
505.31
Formula
C16H15F6N5O.H3O4P
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
(3R)-3-Amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-1-butanone phosphate
CAS Number
654671-78-0
PubChem ID
6451150
InChI Key
IQFYVLUXQXSJJN-SBSPUUFOSA-N
SMILES
OP(O)(O)=O.N[C@H](CC1=C(C=C(C(F)=C1)F)F)CC(N2CCN3C(C2)=NN=C3C(F)(F)F)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 25.27 | 50 | |
| DMSO | 25.27 | 50 |
Preparing Stock Solutions
for Sitagliptin phosphate
The following data is based on the product molecular weight 505.31
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 3.96 mL | 19.79 mL | 39.58 mL |
| 2.5 mM | 0.79 mL | 3.96 mL | 7.92 mL |
| 5 mM | 0.40 mL | 1.98 mL | 3.96 mL |
| 25 mM | 0.08 mL | 0.40 mL | 0.79 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
Product Specific Notices for Sitagliptin phosphate
For research use only
Loading...
Loading...