Diprotin A
Tocris Bioscience, part of Bio-Techne | Catalog # 6019
Dipeptidyl peptidase IV (DPP-IV) inhibitor
Key Product Details
Description
Dipeptidyl peptidase IV (DPP-IV) inhibitor
Alternative Names
Ile-Pro-Ile
Product Description
Diprotin A is a dipeptidyl peptidase IV (DPP-IV) inhibitor. Inhibits hydrolysis of incretins, regulating blood glucose levels. Induces Src and vascular endothelium-cadherin phosphorylation, increasing vascular permeability in the retina. Also increases number of viable phenotypic long term repopulating hematopoietic stem cells when harvesting mouse bone marrow in aerobic conditions.Product Specifications
Molecular Weight
341.45
Formula
C17H31N3O4
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
L-Isoleucyl-L-prolyl-L-isoleucine
CAS Number
90614-48-5
PubChem ID
94701
InChI Key
JNTMAZFVYNDPLB-PEDHHIEDSA-N
SMILES
O=C([C@@H](N)[C@@H](C)CC)N1[C@H](C(N[C@H](C(O)=O)[C@@H](C)CC)=O)CCC1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 34.15 | 100 |
Preparing Stock Solutions
for Diprotin A
The following data is based on the product molecular weight 341.45
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.93 mL | 14.64 mL | 29.29 mL |
| 5 mM | 0.59 mL | 2.93 mL | 5.86 mL |
| 10 mM | 0.29 mL | 1.46 mL | 2.93 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.59 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Lim Role of dipeptidyl peptidase-4 inhibitors in new-onset diabetes after transplantation. Korean J.Intern.Med. 2015 PMID: 26552451
- Lee Dipeptidyl peptidase-4 inhibitor increases vascular leakage in retina through VE-cadherin phosphorylation. Sci.Rep. 2016 PMID: 27381080
- Juillerat-Jeanneret Dipeptidyl peptidase IV and its inhibitors: therapeutics for type 2 diabetes and what else? J.Med.Chem. 2014 PMID: 24099035
Product Specific Notices for Diprotin A
For research use only
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