Saxagliptin hydrochloride is a high affinity DPP-IV inhibitor (K_i = 0.6 nM). Inhibits plasma DPP-IV (87%). Elicits enhanced glucose clearance in Zucker^fa/fa rats.

Product Specifications

Molecular Weight

351.87

Formula

C₁₈H₂₅N₃O₂.HCl

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(1S,3S,5S)-2-[(2S)-Amino(3-hydroxytricyclo[3.3.1.1^3,7]dec-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile hydrochloride

CAS Number

709031-78-7

PubChem ID

56841574

InChI Key

TUAZNHHHYVBVBR-RIKNOMPASA-N

SMILES

N[C@@H](C12CC3CC(C2)CC(C3)(C1)O)C(N4[C@H]5C[C@H]5C[C@H]4C#N)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	35.19	100
	DMSO	35.19	100

Preparing Stock Solutions for Saxagliptin hydrochloride

The following data is based on the product molecular weight 351.87

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.84 mL	14.21 mL	28.42 mL
5 mM	0.57 mL	2.84 mL	5.68 mL
10 mM	0.28 mL	1.42 mL	2.84 mL
50 mM	0.06 mL	0.28 mL	0.57 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Augeri Discovery and preclinical profile of saxagl. (BMS-477118): a highly potent, long-acting, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. J.Med.Chem. 2005 PMID: 16033281

Saxagliptin hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 6507

Key Product Details

Description

Alternative Names

View all DPPIV/CD26 Inhibitors »

Product Description