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156 results for "Degrader Building Blocks" in Products

Degrader Building Blocks Products

Functionalized VHL building block for copper-free click chemistry

Chemical Name: ((1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-yl)methyl ((S)-14-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidine-1-carbonyl)-15,15-dimethyl-12-oxo-3,6,9-trioxa-13-azahexadecyl)carbamate
Purity: ≥90% (HPLC)
Functionalized VHL building block for copper-free click chemistry

Asialoglycoprotein receptor ligand with alkylC5 linker and amine group for onward chemistry

Chemical Name: N-[2-[[1-[2-[2-[2-[2-[[2-(Acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methoxy]-1,1-bis[[[1-[2-[2-[2-[2-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methoxy]methyl]ethyl]-6-aminohexanamide
Asialoglycoprotein receptor ligand with alkylC5 linker and amine group for onward chemistry

Asialoglycoprotein receptor ligand with PEG linker and carboxylic acid group for onward chemistry

Chemical Name: 36-[[2-(Acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-21,21-bis[[3-[[3-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]propyl]amino]-3-oxopropoxy]methyl]-19,26,32-trioxo-4,7,10,13,16,23-hexaoxa-20,27,31-triazahexatriacontanoic acid
Purity: ≥90% (HPLC)
Asialoglycoprotein receptor ligand with PEG linker and carboxylic acid group for onward chemistry

Functionalized cereblon ligand for generating Degrader negative controls; also used as Pomalidomide negative control

Chemical Name: 4-Amino-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
Purity: ≥95% (HPLC)
Functionalized cereblon ligand for generating Degrader negative controls; also used as Pomalidomide negative control

Functionalized VHL ligand for PROTACs

Chemical Name: (4R)-3-Methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-L-prolinamide dihydrochloride
Purity: ≥98% (HPLC)
Functionalized VHL ligand for PROTACs

VHL ligand with PEG linker and terminal amine for onward chemistry

Alternate Names: (S,R,S)-AHPC-PEG3-NH2
Chemical Name: (2S,4R)-1-((S)-14-amino-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecan-1-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride
Purity: ≥95% (HPLC)
VHL ligand with PEG linker and terminal amine for onward chemistry

DCAF1 WD40 ligand with terminal amine for onward chemistry

Chemical Name: 1-(4-(4-((2-Aminoethyl)amino)-2-(1-(4-chlorophenyl)cyclohexyl)quinazolin-7-yl)piperazin-1-yl)ethan-1-one
Purity: ≥98% (HPLC)
DCAF1 WD40 ligand with terminal amine for onward chemistry

VHL ligand with PEG linker and terminal amine for onward chemistry

Alternate Names: (S,R,S)-AHPC-PEG1-NH2
Chemical Name: (2S,4R)-1-((S)-2-(2-(2-Aminoethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride
Purity: ≥95% (HPLC)
VHL ligand with PEG linker and terminal amine for onward chemistry

Asialoglycoprotein receptor ligands with PEG3 linker and azide group for onward chemistry

Purity: ≥90% (HPLC)
Asialoglycoprotein receptor ligands with PEG3 linker and azide group for onward chemistry

Cereblon ligand with alkyl linker and terminal amine for onward chemistry

Chemical Name: 4-[(8-Aminooctyl)oxy]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione hydrochloride
Purity: ≥95% (HPLC)
Cereblon ligand with alkyl linker and terminal amine for onward chemistry

Hydroxyl functionalized VHL ligand

Chemical Name: (2S,4R)-1-((S)-2-(1-Fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(2-hydroxy-4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity: ≥98% (HPLC)
Hydroxyl functionalized VHL ligand

Cereblon ligand with alkyl linker and terminal acid for onward chemistry

Chemical Name: 9-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]nonanoic acid
Purity: ≥95% (HPLC)
Cereblon ligand with alkyl linker and terminal acid for onward chemistry

Functionalized VHL ligand for PROTAC® development

Chemical Name: (2S,4R)-1-((R)-2-Acetamido-3-mercapto-3-methylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity: ≥95% (HPLC)
Functionalized VHL ligand for PROTAC® development

VHL ligand with alkyl linker and terminal amine for onward chemistry

Alternate Names: (S,R,S)-AHPC-C2-NH2
Chemical Name: (2S,4R)-1-((S)-2-(3-Aminopropanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride
Purity: ≥95% (HPLC)
VHL ligand with alkyl linker and terminal amine for onward chemistry

Asialoglycoprotein receptor ligand with PEG4 linker and azide group for onward chemistry

Chemical Name: 2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethyl 2-(acetylamino)-2-deoxy-β-D-galactopyranoside
Purity: ≥95% (HPLC)
Asialoglycoprotein receptor ligand with PEG4 linker and azide group for onward chemistry

Cereblon ligand with alkyl linker and terminal amine for onward chemistry

Chemical Name: 4-[(6-Aminohexyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione hydrochloride
Purity: ≥95% (HPLC)
Cereblon ligand with alkyl linker and terminal amine for onward chemistry

VHL ligand, carboxylic acid functionalized at the benzylic position

Chemical Name: (S)-3-[[[(2S,4R)-1-[(S)-2-(1-Fluorocyclopropan-1-ylcarbonylamino)-3,3-dimethylbutanoyl]-4-hydroxypyrrolidin-2-yl]carbonyl]amino]-3-[4-(4-methylthiazol-5-yl)phenyl]propanoic acid
Purity: ≥98% (HPLC)
VHL ligand, carboxylic acid functionalized at the benzylic position

Functionalized cereblon ligand for PROTAC development

Chemical Name: 2-(4-(2,6-Dioxopiperidin-3-yl)phenoxy)acetic acid
Purity: ≥95% (HPLC)
Functionalized cereblon ligand for PROTAC development

Cereblon ligand with alkyl linker and terminal azide for onward chemistry

Chemical Name: 4-[(5-Azidopentyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
Purity: ≥95% (HPLC)
Cereblon ligand with alkyl linker and terminal azide for onward chemistry

Cereblon ligand with alkyl linker and terminal azide for onward chemistry

Chemical Name: 4-[(4-Azidobutyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
Purity: ≥95% (HPLC)
Cereblon ligand with alkyl linker and terminal azide for onward chemistry

Functionalized IAP ligand for PROTACs

Chemical Name: tert-Butyl ((S)-1-(((S)-1-cyclohexyl-2-((S)-2-(4-(3-hydroxybenzoyl)thiazol-2-yl)pyrrolidin-1-yl)-2-oxoethyl)amino)-1-oxopropan-2-yl)(methyl)carbamate
Purity: ≥95% (HPLC)
Functionalized IAP ligand for PROTACs

Cereblon ligand with alkyl linker and terminal acid for onward chemistry

Chemical Name: 7-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]heptanoic acid
Purity: ≥95% (HPLC)
Cereblon ligand with alkyl linker and terminal acid for onward chemistry

Cereblon ligand with amine on C5 for onward chemistry

Chemical Name: 5-Amino-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
Purity: ≥95% (HPLC)
Cereblon ligand with amine on C5 for onward chemistry

Cereblon ligand with alkyl linker and terminal azide for onward chemistry

Chemical Name: 4-[(6-Azidohexyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
Purity: ≥95% (HPLC)
Cereblon ligand with alkyl linker and terminal azide for onward chemistry

Cereblon ligand with alkyl linker and terminal amine for onward chemistry

Chemical Name: 5-[(8-Aminooctyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione hydrochloride
Purity: ≥95% (HPLC)
Cereblon ligand with alkyl linker and terminal amine for onward chemistry
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