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CXCL4/PF4 Products
CXCL4/PF4 is a secreted chemokine that is expressed by megakaryocytes and restrains the coagulation cascade. It is released by activated platelets and regulates Thrombin/Thrombomodulin complexes, activated Protein C (APC), Coagulation Factor Xa, and Fibrin. The anticoagulant heparin neutralizes CXCL4 procoagulant effects. Complexes of heparin and CXCL4 trigger antibody formation that causes the pathological syndrome HITT. Immunogenic complexes of CXCL4 with Apolipoprotein H contribute to antiphospholipid syndrome (APS). CXCL4 interferes with the proliferative and angiogenic functions of FGF-2 and VEGF. However, it can also exert proinflammatory and pro-atherogenic effects on monocytes, macrophages, and endothelial cells. CXCL4 may signal through CXCR3B in humans.
30 results for "CXCL4/PF4" in Products
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CXCL4/PF4 Products
CXCL4/PF4 is a secreted chemokine that is expressed by megakaryocytes and restrains the coagulation cascade. It is released by activated platelets and regulates Thrombin/Thrombomodulin complexes, activated Protein C (APC), Coagulation Factor Xa, and Fibrin. The anticoagulant heparin neutralizes CXCL4 procoagulant effects. Complexes of heparin and CXCL4 trigger antibody formation that causes the pathological syndrome HITT. Immunogenic complexes of CXCL4 with Apolipoprotein H contribute to antiphospholipid syndrome (APS). CXCL4 interferes with the proliferative and angiogenic functions of FGF-2 and VEGF. However, it can also exert proinflammatory and pro-atherogenic effects on monocytes, macrophages, and endothelial cells. CXCL4 may signal through CXCR3B in humans.
30 results for "CXCL4/PF4" in Products
| Sensitivity : | 0.1 ng/mL |
| Assay Range : | 0.781 - 50 ng/mL (Cell Culture Supernates, Serum, Platelet-poor EDTA Plasma, Platelet-poor Heparin Plasma) |
| Applications : | ELISA |
| Sensitivity : | 0.01 ng/mL |
| Assay Range : | 0.078 - 5 ng/mL (Cell Culture Supernates, Serum, Platelet-poor EDTA Plasma, Platelet-poor Heparin Plasma) |
| Applications : | ELISA |
| Source : | E. coli |
| Accession # : | P02776.2 |
| Applications : | Bioactivity |
| Assay Range : | 15.6 - 1,000 pg/mL |
| Applications : | ELISA |
| Assay Range : | 31.2 - 2,000 pg/mL |
| Applications : | ELISA |
| Source : | E. coli |
| Accession # : | Q9Z126 |
| Applications : | Binding Activity |
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | Simple Western, Western Blot |
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | Simple Western, Western Blot |
| Source : | HEK293 |
| Accession # : | P02776 |
| Applications : | Bioactivity |
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | ELISA Detection, Western Blot |
| Clonality : | Monoclonal |
| Host : | Rat IgG2b Clone #140910 |
| Applications : | ELISA Capture, Western Blot |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2b Clone #170138 |
| Applications : | CyTOF-ready, Flow Cytometry, Western Blot |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2b Clone #170131 |
| Applications : | ELISA Capture |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2b Clone #170138 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #170106 |
| Applications : | Simple Western, Western Blot |
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | ELISA Detection, Western Blot |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2b Clone #170138 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2b Clone #170138 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2b Clone #170138 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2b Clone #170138 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2b Clone #170138 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2b Clone #170138 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2b Clone #170138 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2b Clone #170138 |
| Applications : | Flow Cytometry |
| Source : | E. coli |
| Accession # : | P06765 |
| Applications : | Bioactivity |
