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CXCL4/PF4 Products
CXCL4/PF4 is a secreted chemokine that is expressed by megakaryocytes and restrains the coagulation cascade. It is released by activated platelets and regulates Thrombin/Thrombomodulin complexes, activated Protein C (APC), Coagulation Factor Xa, and Fibrin. The anticoagulant heparin neutralizes CXCL4 procoagulant effects. Complexes of heparin and CXCL4 trigger antibody formation that causes the pathological syndrome HITT. Immunogenic complexes of CXCL4 with Apolipoprotein H contribute to antiphospholipid syndrome (APS). CXCL4 interferes with the proliferative and angiogenic functions of FGF-2 and VEGF. However, it can also exert proinflammatory and pro-atherogenic effects on monocytes, macrophages, and endothelial cells. CXCL4 may signal through CXCR3B in humans.
31 results for "CXCL4/PF4" in Products
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CXCL4/PF4 Products
CXCL4/PF4 is a secreted chemokine that is expressed by megakaryocytes and restrains the coagulation cascade. It is released by activated platelets and regulates Thrombin/Thrombomodulin complexes, activated Protein C (APC), Coagulation Factor Xa, and Fibrin. The anticoagulant heparin neutralizes CXCL4 procoagulant effects. Complexes of heparin and CXCL4 trigger antibody formation that causes the pathological syndrome HITT. Immunogenic complexes of CXCL4 with Apolipoprotein H contribute to antiphospholipid syndrome (APS). CXCL4 interferes with the proliferative and angiogenic functions of FGF-2 and VEGF. However, it can also exert proinflammatory and pro-atherogenic effects on monocytes, macrophages, and endothelial cells. CXCL4 may signal through CXCR3B in humans.
31 results for "CXCL4/PF4" in Products
Luminex Discovery Assays provide the most flexible assays on the market. These panels are completely customizable using our large menu of human, mouse, and rat analytes, making them the perfect tool for biomarker discovery and screening.
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Contains 4 membranes - each spotted in duplicate with 105 different cytokine antibodies
Contains 4 membranes - each spotted in duplicate with 55 different angiogenesis antibodies
Contains 4 membranes - each spotted in duplicate with 31 different chemokine antibodies
| Sensitivity : | 0.1 ng/mL |
| Assay Range : | 0.781 - 50 ng/mL (Cell Culture Supernates, Serum, Platelet-poor EDTA Plasma, Platelet-poor Heparin Plasma) |
| Applications : | ELISA |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #170106 |
| Applications : | Simple Western, Western Blot |
| Source : | E. coli |
| Accession # : | P02776.2 |
| Applications : | Bioactivity |
| Source : | E. coli |
| Accession # : | Q9Z126 |
| Applications : | Binding Activity |
| Sensitivity : | 0.01 ng/mL |
| Assay Range : | 0.078 - 5 ng/mL (Cell Culture Supernates, Serum, Platelet-poor EDTA Plasma, Platelet-poor Heparin Plasma) |
| Applications : | ELISA |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2b Clone #170138 |
| Applications : | CyTOF-ready, Flow Cytometry, Western Blot |
| Assay Range : | 31.2 - 2,000 pg/mL |
| Applications : | ELISA |
| Assay Range : | 15.6 - 1,000 pg/mL |
| Applications : | ELISA |
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | ELISA Detection, Western Blot |
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | ELISA Detection, Western Blot |
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | Simple Western, Western Blot |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2b Clone #170131 |
| Applications : | ELISA Capture |
| Clonality : | Monoclonal |
| Host : | Rat IgG2b Clone #140910 |
| Applications : | ELISA Capture, Western Blot |
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | Simple Western, Western Blot |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2b Clone #170138 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2b Clone #170138 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2b Clone #170138 |
| Applications : | Flow Cytometry |
| Source : | E. coli |
| Accession # : | P06765 |
| Applications : | Bioactivity |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2b Clone #170138 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2b Clone #170138 |
| Applications : | Flow Cytometry |
| Source : | HEK293 |
| Accession # : | P02776 |
| Applications : | Bioactivity |
