Calcium-Sensitive Protease Modulator Inhibitors: Small Molecules and Peptides

Calpain and cathepsin are calcium-sensitive proteases. Calpains are a family of 14 cysteine proteases that are involved in a range of cellular processes. These include remodeling of cytoskeletal attachments to the plasma membrane during cell fusion and cell motility, proteolytic modification of molecules in signal transduction pathways, degradation of enzymes controling progression through the cell cycle, regulation of gene expression, substrate degradation in some apoptotic pathways, and an ...