SID 26681509
Tocris Bioscience, part of Bio-Techne | Catalog # 3625
Cathepsin L inhibitor
Product Description
SID 26681509 is a potent and reversible human cathepsin L inhibitor (IC50 = 56 nM). Displays no inhibitory activity at cathepsin G. Antimalarial; inhibits leishmaniasis.Product Specifications
Molecular Weight
539.65
Formula
C27H33N5O5S
Storage
Store at -20°C
Purity
≥97% (HPLC)
Chemical Name
N-[(1,1-Dimethylethoxy)carbonyl]-L-tryptophan-2-[[[2-[(2-ethylphenyl)amino]-2-oxoethyl]thio]carbonyl]hydrazide
CAS Number
958772-66-2
PubChem ID
16725315
InChI Key
OTIWAYTTYNFEKL-QFIPXVFZSA-N
SMILES
O=C(NNC(SCC(NC1=C(CC)C=CC=C1)=O)=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(OC(C)(C)C)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 26.98 | 50 | |
| Ethanol | 5.4 | 10 |
Preparing Stock Solutions
for SID 26681509
The following data is based on the product molecular weight 539.65
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 3.71 mL | 18.53 mL | 37.06 mL |
| 2.5 mM | 0.74 mL | 3.71 mL | 7.41 mL |
| 5 mM | 0.37 mL | 1.85 mL | 3.71 mL |
| 25 mM | 0.07 mL | 0.37 mL | 0.74 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Myers Identification and synthesis of a unique thiocarbazate cathepsin L inhibitor. Bioorg.Med.Chem.Lett. 2008 PMID: 18060772
- Shah Kinetic characterization and molecular docking of a novel, potent and selective slow-binding inhibitor of human cathepsin L. Mol.Pharmacol. 2008 PMID: 18403718
Product Specific Notices for SID 26681509
For research use only
Loading...
Loading...
Loading...