CA 074

Name: CA 074
Brand: Tocris Bioscience
SKU: 4863

Tocris Bioscience, part of Bio-Techne | Catalog # 4863

Citations (15)

COA / SDS

Selective cathepsin B inhibitor

Key Product Details

Description:	Selective cathepsin B inhibitor
Chemical Name:	N-[[(2S,3S)-3-[(Propylamino)carbonyl]-2-oxiranyl]carbonyl]-L-isoleucyl-L-proline
Purity:	≥98% (HPLC)
Molecular Weight:	383.44

View Full Technical Details for CA 074

Technical Data
Citations

Biological Activity for CA 074

CA 074 is an inhibitor of cathepsin B (K_i = 2-5 nM). Displays selectivity over cathepsins H and L (K_i = 40-200 μM). Shown to reduce bone metastasis in a 4T1.2 breast cancer model.

Technical Data for CA 074

M. Wt	383.44
Formula	C₁₈H₂₉N₃O₆
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	134448-10-5
PubChem ID	9821383
InChi Key	ZEZGJKSEBRELAS-PEDHHIEDSA-N
Smiles	O=[C@](NCCC)[C@H]1O[C@@H]1[C@@](N[C@@H]([C@@H](C)CC)[C@](N2[C@H](C(O)=O)CCC2)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CA 074

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	ethanol	7.67	20

Preparing Stock Solutions for CA 074

The following data is based on the product molecular weight 383.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	13.04 mL	65.20 mL	130.40 mL
1 mM	2.61 mL	13.04 mL	26.08 mL
2 mM	1.30 mL	6.52 mL	13.04 mL
10 mM	0.26 mL	1.30 mL	2.61 mL

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References for CA 074

References are publications that support the biological activity of the product.

Towatari Novel epoxysuccinyl peptides. A selective inhibitor of cathepsin B, in vivo. FEBS Lett. 1991 PMID: 2013329
Withana Cathepsin B inhibition limits bone metastasis in breast cancer. Cancer Res. 2012 PMID: 22266111
Gillet Voltage-gated sodium channel activity promotes cysteine cathepsin-dependent invasiveness and colony growth of human cancer cells. J.Biol.Chem. 2009 PMID: 19176528