L 006235

Name: L 006235
Brand: Tocris Bioscience
SKU: 3066

Tocris Bioscience, part of Bio-Techne | Catalog # 3066

Citations (4)

COA / SDS

Potent cathepsin K inhibitor

Key Product Details

Description:	Potent cathepsin K inhibitor
Chemical Name:	N-[1-[[(Cyanomethyl)amino]carbonyl]cyclohexyl]-4-[2-(4-methyl-1-piperazinyl)-4-thiazolyl]benzamide
Purity:	≥98% (HPLC)
Molecular Weight:	466.6

View Full Technical Details for L 006235

Technical Data
Citations

Biological Activity for L 006235

L 006235 is a potent, reversible cathepsin K inhibitor (IC₅₀ = 0.25 nM) that displays > 4000-fold selectivity over cathepsins B, L and S. Displays reduced selectivity in cell-based assays possibly due to lysosomal accumulation. Reduces collagen breakdown and promotes bone deposition in vivo. Orally active and has intrinsic fluorescence.

Compound Libraries for L 006235

L 006235 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for L 006235

M. Wt	466.6
Formula	C₂₄H₃₀N₆O₂S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	294623-49-7
PubChem ID	9912381
InChi Key	FIVYCSWOCXEWSE-UHFFFAOYSA-N
Smiles	O=C(C2=CC=C(C3=CSC(N4CCN(C)CC4)=N3)C=C2)NC1(CCCCC1)C(NCC#N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for L 006235

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	46.66	100

Preparing Stock Solutions for L 006235

The following data is based on the product molecular weight 466.6.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.14 mL	10.72 mL	21.43 mL
5 mM	0.43 mL	2.14 mL	4.29 mL
10 mM	0.21 mL	1.07 mL	2.14 mL
50 mM	0.04 mL	0.21 mL	0.43 mL

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References for L 006235

References are publications that support the biological activity of the product.

Falgueyret Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity. J.Med.Chem. 2005 PMID: 16302795
Desmarais Effects of cathepsin K inhibitors basicity on in vivo off-target activities. Mol.Pharmacol. 2008 PMID: 17940194
Palmer Design and synthesis of tri-ring P₃ benamide-containing aminonitriles as potent, selective, orally effective inhibitors of cathepsin K. J.Med.Chem. 2005 PMID: 16302794