L 006235
Tocris Bioscience, part of Bio-Techne | Catalog # 3066
Potent cathepsin K inhibitor
Key Product Details
Description
Potent cathepsin K inhibitor
Product Description
L 006235 is a potent, reversible cathepsin K inhibitor (IC50 = 0.25 nM) that displays > 4000-fold selectivity over cathepsins B, L and S. Displays reduced selectivity in cell-based assays possibly due to lysosomal accumulation. Reduces collagen breakdown and promotes bone deposition in vivo. Orally active and has intrinsic fluorescence.Product Specifications
Molecular Weight
466.60
Formula
C24H30N6O2S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-[1-[[(Cyanomethyl)amino]carbonyl]cyclohexyl]-4-[2-(4-methyl-1-piperazinyl)-4-thiazolyl]benzamide
CAS Number
294623-49-7
PubChem ID
9912381
InChI Key
FIVYCSWOCXEWSE-UHFFFAOYSA-N
SMILES
O=C(C2=CC=C(C3=CSC(N4CCN(C)CC4)=N3)C=C2)NC1(CCCCC1)C(NCC#N)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 46.66 | 100 |
Preparing Stock Solutions
for L 006235
The following data is based on the product molecular weight 466.60
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.14 mL | 10.72 mL | 21.43 mL |
| 5 mM | 0.43 mL | 2.14 mL | 4.29 mL |
| 10 mM | 0.21 mL | 1.07 mL | 2.14 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.43 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Falgueyret Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity. J.Med.Chem. 2005 PMID: 16302795
- Desmarais Effects of cathepsin K inhibitors basicity on in vivo off-target activities. Mol.Pharmacol. 2008 PMID: 17940194
- Palmer Design and synthesis of tri-ring P3 benamide-containing aminonitriles as potent, selective, orally effective inhibitors of cathepsin K. J.Med.Chem. 2005 PMID: 16302794
Product Specific Notices for L 006235
For research use only
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