5 results for "Calcium-sensing R/CaSR Small Molecules and Peptides" in Products
Calcium-sensing R/CaSR: Small Molecules and Peptides
Calcium-Sensing Receptor (CaSR) is a member of the G protein-coupled receptor family. CaSR is an integral membrane protein that senses changes in the extracellular concentration of calcium ions and controls the release of parathyroid hormone. The activity of the calcium-sensing receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system.
Mutations that inactivate CaSR lead to familial hypocalciuric hypercalcemia, whereas mutations that activate CaSR cause autosomal dominant hypocalcemia. Calcium-Sensing Receptor antibodies are useful tools for parathyroid studies and research on cellular calcium homeostasis regulation.
Positive allosteric modulator of human calcium-sensing receptor (CaSR)
| Chemical Name: | 2-Chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanamine hydrochloride |
| Purity: | ≥98% (HPLC) |
Allosteric Calcium-sensing receptor (CaSR) agonist; also CYP2D2 inhibitor and Ca2+ channel blocker; orally bioavailable
| Alternate Names: | AMG 073 |
| Chemical Name: | N-[(1R)-1-(1-Naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine hydrochloride |
| Purity: | ≥98% (HPLC) |
Selective calcium-sensing receptor (CaSR) antagonist; orally active calcilytic agent
| Chemical Name: | 2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino-2-hydroxypropoxy]benzonitrile hydrochloride |
| Purity: | ≥98% (HPLC) |
Biased allosteric modulator of calcium-sensing receptor (CaSR)
| Chemical Name: | α-(2,4-Dimethylphenyl)-α-methyl-2-benzothiazolemethanol |
| Purity: | ≥98% (HPLC) |
Negative allosteric modulator of calcium-sensing receptor (CaSR)
| Chemical Name: | 4-Chloro-N-[(1S,2S)-2-[[(1R)-1-(1-naphthalenyl)ethyl]amino]cyclohexyl]-benzamide hydrochloride |
| Purity: | ≥98% (HPLC) |
