R 568 hydrochloride

Name: R 568 hydrochloride
Brand: Tocris Bioscience
SKU: 3815

Tocris Bioscience, part of Bio-Techne | Catalog # 3815

Citations (17)

COA / SDS

Positive allosteric modulator of human calcium-sensing receptor (CaSR)

Key Product Details

Description:	Positive allosteric modulator of human calcium-sensing receptor (CaSR)
Chemical Name:	2-Chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanamine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	340.29

View Full Technical Details for R 568 hydrochloride

Technical Data
Citations

Biological Activity for R 568 hydrochloride

R 568 hydrochloride is a positive allosteric modulator and allosteric agonist of the human calcium-sensing receptor (hCaSR). Exhibits calcimimetic activity. Has the ability to restore function to hCaSR mutants that cause familial hypocalciuric hypercalcemia (FHH) and neonatal severe hyperparathyroidism (NSHPT). Exerts a suppressive effect on parathyroid (PT) hormone secretion; inhibits PT cell proliferation in rats with renal insufficiency.

Compound Libraries for R 568 hydrochloride

R 568 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for R 568 hydrochloride

M. Wt	340.29
Formula	C₁₈H₂₂ClNO.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	177172-49-5
PubChem ID	158796
InChi Key	YJXUXANREVNZLH-PFEQFJNWSA-N
Smiles	ClC(C=CC=C2)=C2CCCN[C@H](C)C1=CC=CC(OC)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for R 568 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	34.03	100
	ethanol	34.03	100

Preparing Stock Solutions for R 568 hydrochloride

The following data is based on the product molecular weight 340.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.94 mL	14.69 mL	29.39 mL
5 mM	0.59 mL	2.94 mL	5.88 mL
10 mM	0.29 mL	1.47 mL	2.94 mL
50 mM	0.06 mL	0.29 mL	0.59 mL

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References for R 568 hydrochloride

References are publications that support the biological activity of the product.

Fox NPS R-568: a type II calcimimetic compound that acts on parathyroid cell calcium receptor of rats to reduce plasma levels of parathyroid hormone and calcium. J.Pharmacol.Exp.Ther. 1999 PMID: 10411552
Ying Lin Lu Effect of the calcimimetic R-568 [3-(2-chlorophenyl)-N-((1R)-1-(3-methoxyphenyl)ethyl)-1-propanamine] on correcting inactivating mutations in the human calcium-sensing receptor. J.Pharmacol.Exp.Ther. 2009 PMID: 19759318
Wada The calcimimetic compound NPS R-568 suppresses parathyroid cell proliferation in rats with renal insufficiency. J.Clin.Invest. 1997 PMID: 9399943