AC 265347

Name: AC 265347
Brand: Tocris Bioscience
SKU: 6165

Tocris Bioscience, part of Bio-Techne | Catalog # 6165

Citations (3)

COA / SDS

Biased allosteric modulator of calcium-sensing receptor (CaSR)

Key Product Details

Description:	Biased allosteric modulator of calcium-sensing receptor (CaSR)
Chemical Name:	α-(2,4-Dimethylphenyl)-α-methyl-2-benzothiazolemethanol
Purity:	≥98% (HPLC)
Molecular Weight:	283.39

View Full Technical Details for AC 265347

Technical Data
Citations

Biological Activity for AC 265347

AC 265347 is a CaSR biased allosteric modulator (pEC₅₀ = 7.8-8.1). Calcimimetic. Displays ability to bias signalling towards the accumulation of pERK1/2 and IP₁. Reduces parathyroid hormone (PTH) levels in rat serum without inducing the release of calcitonin. Exhibits no significant activation of human GABA_B or type I PTH receptors. Orally active.

Compound Libraries for AC 265347

AC 265347 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for AC 265347

M. Wt	283.39
Formula	C₁₇H₁₇NOS
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1253901-26-6
PubChem ID	52943938
InChi Key	IGSZVEPQZANNAB-UHFFFAOYSA-N
Smiles	CC1=CC(C)=C(C(O)(C2=NC3=CC=CC=C3S2)C)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AC 265347

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	28.34	100
	ethanol	28.34	100

Preparing Stock Solutions for AC 265347

The following data is based on the product molecular weight 283.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.53 mL	17.64 mL	35.29 mL
5 mM	0.71 mL	3.53 mL	7.06 mL
10 mM	0.35 mL	1.76 mL	3.53 mL
50 mM	0.07 mL	0.35 mL	0.71 mL

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References for AC 265347

References are publications that support the biological activity of the product.

Ma Characterization of highly efficacious allosteric agonists of the human calcium-sensing receptor. J.Pharmacol.Exp.Ther. 2011 PMID: 21239511
Leach Towards a structural understanding of allosteric drugs at the human calcium-sensing receptor. Cell.Res. 2016 PMID: 27002221
Cook Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics. Br.J.Pharmacol. 2015 PMID: 25220431