NPS 2143 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 3626
Selective calcium-sensing receptor (CaSR) antagonist; orally active calcilytic agent
Key Product Details
Description
Selective calcium-sensing receptor (CaSR) antagonist; orally active calcilytic agent
Product Description
NPS 2143 hydrochloride is a selective Ca2+-sensing receptor antagonist. Blocks increases in cytoplasmic Ca2+ concentrations elicited by human Ca2+ receptors expressed in HEK293 cells (IC50 = 43 nM). Also stimulates parathyroid hormone secretion from bovine parathyroid cells (EC50 = 41 nM). Orally active calcilytic compound.Product Specifications
Molecular Weight
445.38
Formula
C24H25ClN2O2.HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino-2-hydroxypropoxy]benzonitrile hydrochloride
CAS Number
324523-20-8
PubChem ID
9868131
InChI Key
ZEBNDUQLNGYBNL-VEIFNGETSA-N
SMILES
CC(NC[C@@H](O)COC3=C(C#N)C(Cl)=CC=C3)(C)CC2=CC1=CC=CC=C1C=C2.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 44.54 | 100 | |
| Ethanol | 4.45 | 10 |
Preparing Stock Solutions
for NPS 2143 hydrochloride
The following data is based on the product molecular weight 445.38
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.25 mL | 11.23 mL | 22.45 mL |
| 5 mM | 0.45 mL | 2.25 mL | 4.49 mL |
| 10 mM | 0.22 mL | 1.12 mL | 2.25 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.45 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Nemeth The search for calcium receptor antagonists (calcilytics). J.Mol.Endocrinol. 2002 PMID: 12200226
- Huang and Breitwieser Rescue of calcium-sensing receptor mutants by allosteric modulators reveals a conformational checkpoint in receptor biogenesis. J.Biol.Chem. 2007 PMID: 17284438
- Nemeth Calcilytic compounds: potent and selective Ca2+ receptor antagonists that stimulate secretion of parathyroid hormone. J.Pharmacol.Exp.Ther. 2001 PMID: 11561095
Product Specific Notices for NPS 2143 hydrochloride
For research use only
Loading...
Loading...