Calhex 231 hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 4387

Negative allosteric modulator of calcium-sensing receptor (CaSR)
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Key Product Details

Description

Negative allosteric modulator of calcium-sensing receptor (CaSR)

View all Calcium-Sensing Receptor Modulators »

Product Description

Calhex 231 hydrochloride is a negative allosteric modulator of the calcium sensing receptor (CaSR). Blocks increases in [3H]inositol phosphate levels elicited by wild-type hCasR activation (IC50= 0.39 μM in transiently transfected HEK293 cells).

Product Specifications

Molecular Weight

443.41

Formula

C25H27ClN2O.HCl

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

4-Chloro-N-[(1S,2S)-2-[[(1R)-1-(1-naphthalenyl)ethyl]amino]cyclohexyl]-benzamide hydrochloride

CAS Number

2387505-78-2

PubChem ID

11849513

InChI Key

KZPHZSFSFANQIS-GRFVZBLOSA-N

SMILES

O=C(C4=CC=C(Cl)C=C4)N[C@@H](CCCC3)[C@H]3N[C@H](C)C1=C2C(C=CC=C2)=CC=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 22.17 50

Preparing Stock Solutions for Calhex 231 hydrochloride

The following data is based on the product molecular weight 443.41

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.51 mL 22.55 mL 45.10 mL
2.5 mM 0.90 mL 4.51 mL 9.02 mL
5 mM 0.45 mL 2.26 mL 4.51 mL
25 mM 0.09 mL 0.45 mL 0.90 mL

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Product Documents for Calhex 231 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Calhex 231 hydrochloride

For research use only

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