Calhex 231 hydrochloride

Name: Calhex 231 hydrochloride
Brand: Tocris Bioscience
SKU: 4387

Tocris Bioscience, part of Bio-Techne | Catalog # 4387

Citations (4)

COA / SDS

Negative allosteric modulator of calcium-sensing receptor (CaSR)

Key Product Details

Description:	Negative allosteric modulator of calcium-sensing receptor (CaSR)
Chemical Name:	4-Chloro-N-[(1S,2S)-2-[[(1R)-1-(1-naphthalenyl)ethyl]amino]cyclohexyl]-benzamide hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	443.41

View Full Technical Details for Calhex 231 hydrochloride

Technical Data
Citations

Biological Activity for Calhex 231 hydrochloride

Calhex 231 hydrochloride is a negative allosteric modulator of the calcium sensing receptor (CaSR). Blocks increases in [³H]inositol phosphate levels elicited by wild-type hCasR activation (IC₅₀= 0.39 μM in transiently transfected HEK293 cells).

Compound Libraries for Calhex 231 hydrochloride

Calhex 231 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Calhex 231 hydrochloride

M. Wt	443.41
Formula	C₂₅H₂₇ClN₂O.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2387505-78-2
PubChem ID	11849513
InChi Key	KZPHZSFSFANQIS-GRFVZBLOSA-N
Smiles	O=C(C4=CC=C(Cl)C=C4)N[C@@H](CCCC3)[C@H]3N[C@H](C)C1=C2C(C=CC=C2)=CC=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Calhex 231 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	22.17	50

Preparing Stock Solutions for Calhex 231 hydrochloride

The following data is based on the product molecular weight 443.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.51 mL	22.55 mL	45.10 mL
2.5 mM	0.90 mL	4.51 mL	9.02 mL
5 mM	0.45 mL	2.26 mL	4.51 mL
25 mM	0.09 mL	0.45 mL	0.90 mL

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References for Calhex 231 hydrochloride

References are publications that support the biological activity of the product.

Kessler N1-Benzoyl-N2-[1-(1-naphthyl)ethyl]-trans-1,2-diaminocyclohexanes: Development of 4-chlorophenylcarboxamide (Calhex 231) as a new calcium sensing receptor ligand demonstrating potent calcilytic activity. J.Med.Chem. 2006 PMID: 16913701
Weston The expression and function of Ca²⁺-sensing receptors in rat mesenteric artery; comparative studies using a model of type II diabetes. Br.J.Pharmacol. 2008 PMID: 18414396
Petrel Modeling and mutagenesis of the binding site of Calhex 231, a novel negative allosteric modulator of the extracellular Ca²⁺-sensing receptor. J.Biol.Chem. 2003 PMID: 14506236