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10 results for "BMP and Other Activin Receptor Inhibitors Small Molecules and Peptides" in Products

BMP and Other Activin Receptor Inhibitors: Small Molecules and Peptides

Activin receptors transduce signals carried by the TGF-β family of ligands. Such ligands include activin and bone morphogenetic proteins (BMPs). Members of this family are involved in a range of processes, including embryogenesis and tissue homeostasis.

Bone morphogenetic proteins (BMPs) are a group of growth factors belonging to the transforming growth factor-β (TGF-β) superfamily (excluding BMP1). Primarily characterized by their effects on bone and cartilage formation, ...

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Selective inhibitor of TGF-βRI, ALK4 and ALK7

Chemical Name: 3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide
Purity: ≥98% (HPLC)
Adult Stem Cell-derived Liver Organoids
(6)

Potent and selective ALK2 and ALK3 inhibitor; inhibits BMP4 signaling; promotes neural induction of hPSCs

Chemical Name: 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride
Purity: ≥98% (HPLC)
Application of LDN 193189 in motor neurons differentiated from iPSCs
(2)

Potent AMPK inhibitor; also BMP type I receptor inhibitor

Alternate Names: Compound C,BML-275
Chemical Name: 6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-pyrazolo[1,5-a]pyrimidine dihydrochloride
Purity: ≥98% (HPLC)
Potent AMPK inhibitor; also BMP type I receptor inhibitor

Selective ALK2 inhibitor

Chemical Name: 4-[6-[4-(1-Methylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline
Purity: ≥98% (HPLC)
Selective ALK2 inhibitor

Type I BMP receptor inhibitor

Chemical Name: 4-[6-[4-[2-(4-Morpholinyl)ethoxy]phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline
Purity: ≥98% (HPLC)
Type I BMP receptor inhibitor

Type 1 BMP receptor inhibitor

Alternate Names: K 02288a
Chemical Name: 3-[(6-Amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenol
Purity: ≥98% (HPLC)
Type 1 BMP receptor inhibitor

Selective inhibitor of TGF-βRI, ALK4 and ALK7

Chemical Name: 2-[4-(1,3-Benzodioxol-5-yl)-2-(1,1-dimethylethyl)-1H-imidazol-5-yl]-6-methyl-pyridine
Purity: ≥98% (HPLC)
Selective inhibitor of TGF-βRI, ALK4 and ALK7

A 83-01 synthesized to Ancillary Material Grade

Chemical Name: 3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide
Purity: ≥98%
A 83-01 synthesized to Ancillary Material Grade

Sterile-filtered 10 mM solution of LDN 193189 pre-dissolved in water

Chemical Name: 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride
Purity: ≥97% (HPLC)
Sterile-filtered 10 mM solution of LDN 193189 pre-dissolved in water

Potent and selective ALK1 and ALK2 inhibitor

Alternate Names: LDN 193719,1lWY,VU0469381
Chemical Name: 5-[6-(4-Methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline
Purity: ≥98% (HPLC)
Potent and selective ALK1 and ALK2 inhibitor
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