DMH2

Tocris Bioscience, part of Bio-Techne | Catalog # 5580

Type I BMP receptor inhibitor
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Key Product Details

Description

Type I BMP receptor inhibitor

View all BMP and Other Activin Receptor Inhibitors »

Product Description

DMH2 is a type I BMP receptor inhibitor (Ki values are <1, 5.4 and 43 nM for ALK6, ALK3 and ALK2, respectively). Exhibits >30-fold selectivity over ALK4, ALK5, BMPR2, AMPK and VEGFR2. Also binds to TGFBR2 (Ki = 85 nM). Decreases growth and induces cell death of H1299 non-small cell lung carcinoma cells in vitro. Enhances liver regeneration in vivo.

Product Specifications

Molecular Weight

451.52

Formula

C27H25N5O2

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

4-[6-[4-[2-(4-Morpholinyl)ethoxy]phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline

CAS Number

1206711-14-9

PubChem ID

50997748

InChI Key

DXLXRNZCYAYUED-UHFFFAOYSA-N

SMILES

C(C=N2)(C3=CC=C(OCCN4CCOCC4)C=C3)=CN1C2=C(C5=CC=NC6=C5C=CC=C6)C=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
2eq.HCl 22.58 50
DMSO 9.03 20 with gentle warming

Preparing Stock Solutions for DMH2

The following data is based on the product molecular weight 451.52

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.43 mL 22.15 mL 44.29 mL
2.5 mM 0.89 mL 4.43 mL 8.86 mL
5 mM 0.44 mL 2.21 mL 4.43 mL
25 mM 0.09 mL 0.44 mL 0.89 mL

Calculators

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for DMH2

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for DMH2

For research use only

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