K 02288

Tocris Bioscience, part of Bio-Techne | Catalog # 4986

Type 1 BMP receptor inhibitor
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Key Product Details

Description

Type 1 BMP receptor inhibitor

Alternative Names

K 02288a

View all BMP and Other Activin Receptor Inhibitors »

Product Description

K 02288 is a potent and selective inhibitor of type I bone morphogenic protein (BMP) receptors (IC50 values are 1.1, 1.8, 6.4, 34.4, 220, 302 and 321 nM for ALK2, ALK1, ALK6, ALK3, ActRIIA, ALK4 and ALK5 respectively). Reduces BMP4-induced Smad1/5/8 phosphorylation in vitro (IC50 = 100 nM) and induces dorsalization of zebrafish embryos.

Product Specifications

Molecular Weight

352.38

Formula

C20H20N2O4

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

3-[(6-Amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenol

CAS Number

1431985-92-0

PubChem ID

46173038

InChI Key

CJLMANFTWLNAKC-UHFFFAOYSA-N

SMILES

NC1=NC=C(C3=CC=CC(O)=C3)C=C1C2=CC(OC)=C(OC)C(OC)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.24 100
Ethanol 3.52 10 with gentle warming

Preparing Stock Solutions for K 02288

The following data is based on the product molecular weight 352.38

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.84 mL 14.19 mL 28.38 mL
5 mM 0.57 mL 2.84 mL 5.68 mL
10 mM 0.28 mL 1.42 mL 2.84 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for K 02288

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for K 02288

For research use only

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