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APP Products
Amyloid Precursor Protein (APP) is a type I transmembrane protein that is ubiquitously expressed on cell surfaces. It undergoes complex proteolytic processing and is cleaved by alpha-, beta-, and gamma-Secretases to generate soluble APP alpha, soluble APP beta, and Amyloid beta (A beta) fragments of several lengths. One of these fragments, A beta 42, generated by beta- and gamma-Secretase activities, has been implicated in Alzheimer's disease. Aberrantly high levels of this peptide form and accumulate in the brains of Alzheimer's disease patients to create the senile plaques characteristic of the disease.
49 results for "APP" in Products
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APP Products
Amyloid Precursor Protein (APP) is a type I transmembrane protein that is ubiquitously expressed on cell surfaces. It undergoes complex proteolytic processing and is cleaved by alpha-, beta-, and gamma-Secretases to generate soluble APP alpha, soluble APP beta, and Amyloid beta (A beta) fragments of several lengths. One of these fragments, A beta 42, generated by beta- and gamma-Secretase activities, has been implicated in Alzheimer's disease. Aberrantly high levels of this peptide form and accumulate in the brains of Alzheimer's disease patients to create the senile plaques characteristic of the disease.
49 results for "APP" in Products
Luminex Discovery Assays provide the most flexible assays on the market. These panels are completely customizable using our large menu of human, mouse, and rat analytes, making them the perfect tool for biomarker discovery and screening.
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Fluorescent amyloid β detector; brain penetrant
| Chemical Name : | 4,4'-[(2-methoxy-1,4-phenylene)di-(1E)-2,1-ethenediyl]bisphenol |
| Purity : | ≥98% (HPLC) |
Amyloid β-protein fragment
| Purity : | ≥95% (HPLC) |
Contains 4 membranes - 2 spotted in duplicate with 62 different non-hematopoietic antibodies and 2 spotted in duplicate with 57 common antibodies
Predominant amyloid β-protein fragment
| Purity : | ≥95% (HPLC) |
Recombinant Monoclonal Antibody.
| Clonality : | Monoclonal |
| Host : | Mouse IgG Clone #MM26R |
| Applications : | ELISA |
Amyloid fibril-specific fluorescent dye
| Chemical Name : | 4,4'-[(2-Bromo-1,4-phenylene)di-(1E)-2,1-ethenediyl]bisphenol |
| Purity : | ≥98% (HPLC) |
Contains 4 membranes-2 spotted in duplicate with antibodies against 35 different proteases and 2 spotted in duplicate with antibodies against 32 different protease inhibitors
STAT3 activator; also protects against β-amyloid neurotoxicity
Contains 4 membranes - each spotted in duplicate with 32 different protease inhibitor antibodies
| Clonality : | Monoclonal |
| Host : | Mouse IgG Clone #AB42-5 |
| Applications : | ELISA |
| Clonality : | Monoclonal |
| Host : | Mouse IgG Clone #MM32 |
| Applications : | ELISA |
| Assay Range : | 0.625 - 20 ng/mL |
| Applications : | ELISA |
| Source : | NS0 |
| Accession # : | P05067 |
| Applications : | Inhibition Activity |
Neuroprotective and neurotrophic compound; reduces Aβ40 and Aβ42 levels
| Chemical Name : | 2,2,2-Trifluoroacetic acid 1-(2,4-Dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide |
| Purity : | ≥99% (HPLC) |
Antiallergic; inhibits inflammatory mediator release from mast cells
| Chemical Name : | 2-[[3-(3,4-Dimethoxyphenyl)-1-oxo-2-propenyl]amino]benzoic acid |
| Purity : | ≥99% (HPLC) |
Predominant amyloid β-protein fragment
| Purity : | ≥95% (HPLC) |
| Clonality : | Monoclonal |
| Host : | Mouse IgG Clone #MM26 |
| Applications : | ELISA |
β-secretase (BACE) inhibitor; inhibits amyloid assembly
| Alternate Names : | Epigallocatechin gallate |
| Chemical Name : | 3,4,5-Trihydroxybenzoic acid (2R,3R)-3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3-yl ester |
| Purity : | ≥98% (HPLC) |
Potent and selective ERβ agonist; neuroprotective
| Chemical Name : | 4-[4,4-Difluoro-1-(2-fluorophenyl)cyclohexyl]phenol |
| Purity : | ≥99% (HPLC) |
Inhibitor of Aβ42 fibril formation
| Chemical Name : | 2'-(4-Aminophenyl)-[2,5'-bi-1H-benzimidazol]-5-amine |
| Purity : | ≥98% (HPLC) |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #128715 |
| Applications : | Immunoprecipitation, Western Blot |
Recombinant Monoclonal Antibody
| Clonality : | Monoclonal |
| Host : | Mouse IgG Clone #MM32R |
| Applications : | ELISA |
