Colivelin

Name: Colivelin
Brand: Tocris Bioscience
SKU: 3945

Tocris Bioscience, part of Bio-Techne | Catalog # 3945

Citations (20)

COA / SDS

STAT3 activator; also protects against β-amyloid neurotoxicity

Key Product Details

Description:	STAT3 activator; also protects against β-amyloid neurotoxicity
Purity:	≥95% (HPLC)
Molecular Weight:	2645.13

View Full Technical Details for Colivelin

Technical Data
Citations

Biological Activity for Colivelin

Colivelin is a neuroprotective peptide and activator of STAT3. Protects neurons against the neurotoxic effects of amyloid β-peptide (1-43) at a concentration of 100 fM in vitro. Suppresses neuronal death by activating STAT3 in vitro; upregulates cholinergic transmission and ameliorates memory impairment in Alzheimer's disease (AD) models. Also prevents alcohol-induced apoptosis in a fetal mouse model. Brain penetrant.

Technical Data for Colivelin

M. Wt	2645.13
Formula	C₁₁₉H₂₀₆N₃₂O₃₅
Single Letter Sequence	SALLRSIPAPAGASRLLLLTGEIDLP
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	867021-83-8
PubChem ID	90477169
InChi Key	PTTAQOYOJJTWFD-IBAOLXMASA-N
Smiles	[H]N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Colivelin

Solubility

Soluble to 1mg/ml in 20% ethanol / water

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References for Colivelin

References are publications that support the biological activity of the product.

Sari A novel peptide, colivelin, prevents alcohol-induced apoptosis in fetal brain of C57BL/6 mice: signaling pathway investigations. Neuroscience 2009 PMID: 19782727
Yamada Nasal colivelin treatment ameliorates memory impairment related to Alzheimer's disease. Neuropsychopharmacology 2008 PMID: 17928813
Chiba Development of a femtomolar-acting humanin derivative named colivelin by attaching activity-dependent neurotrophic factor to its N terminus: characterization of colivelin-mediated neuroprotection against Alzheimer's disease-relevant insults in vitro a J.Neurosci. 2005 PMID: 16267233