FC 11
Tocris Bioscience, part of Bio-Techne | Catalog # 7306
Highly potent focal adhesion kinase (FAK) Degrader (PROTAC®)
Key Product Details
Description
Highly potent focal adhesion kinase (FAK) Degrader (PROTAC®)
Product Description
FC 11 is a highly potent focal adhesion kinase (FAK) PROTAC® Degrader (DC50 values are 40 to 370 pM depending on cell line), which is composed of the FAK inhibitor PF 562217 joined by a linker to the cereblon-binding ligand Pomalidomide (Cat. No. 6302). The effects of FC 11 are reversible upon compound wash out. FC 11 also degrades autophosphorylated FAK (pFAKtyr397), displaying near complete degradation after 3 hours at 100 nM in TM3 cells.FAK antibodies validated for Simple Western™ (automated Western) instruments and Western Blot also available: Catalog # AF4467 and MAB4467.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Product Specifications
Molecular Weight
949.92
Formula
C41H42F3N13O9S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
1-[2-[2-[2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]-N-[4-[[4-[[[2-[methyl(methylsulfonyl)amino]-3-pyridinyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]phenyl]-1H-1,2,3-triazole-4-carboxamide
CAS Number
2271035-37-9
PubChem ID
154723926
InChI Key
RZKZQCHSKWKOAJ-UHFFFAOYSA-N
SMILES
CN(S(C)(=O)=O)C1=C(C=CC=N1)CNC2=NC(NC3=CC=C(C=C3)NC(C4=CN(N=N4)CCOCCOCCNC5=C6C(N(C(C6=CC=C5)=O)C7CCC(NC7=O)=O)=O)=O)=NC=C2C(F)(F)F
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 94.99 | 100 |
Preparing Stock Solutions
for FC 11
The following data is based on the product molecular weight 949.92
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.05 mL | 5.26 mL | 10.53 mL |
| 5 mM | 0.21 mL | 1.05 mL | 2.11 mL |
| 10 mM | 0.11 mL | 0.53 mL | 1.05 mL |
| 50 mM | 0.02 mL | 0.11 mL | 0.21 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Gao Design, synthesis, and evaluation of highly potent FAK-targeting PROTACs. ACS.Med.Chem.Lett. 2019 PMID: 33062164
Product Specific Notices for FC 11
For research use only
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