How long will recombinant mouse M-CSF last in cell culture?

Name: Recombinant Mouse M-CSF Protein
Brand: R&D Systems
SKU: 416-ML
Rating: 5 (18 reviews)

End-users will need to determine the appropriate concentration and timing when adding Recombinant Mouse M-CSF Proteins to cell culturing experiments. The addition of protein may be dependent on certain culture conditions, including the cell number, density, and media content. For techniques and methodologies, we recommend reviewing our list of publications under the Citations tab on the product-specific web page to find reported use of our products in similar experimental layouts.

Recombinant Mouse M-CSF Protein

R&D Systems, Inc. a Bio-Techne Brand

Catalog # 416-ML

Citations (531)

(18)

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Key Product Details

Source:	E. coli
Accession #:	Q3U4F9
Structure / Form:	Disulfide-linked homodimer
Applications:	Bioactivity

View Full Technical Details for Recombinant Mouse M-CSF Protein

Product Specifications for Recombinant Mouse M-CSF Protein

Source	E. coli-derived mouse M-CSF protein Lys33-Glu262, with an N-terminal Met
Purity	>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin level	<1.0 EU per 1 μg of the protein by the LAL method.
N-terminal sequence Analysis	Met
Predicted Molecular Mass	26 kDa (monomer)
SDS-PAGE	29 kDa, reducing conditions
Activity	Measured in a cell proliferation assay using M‑NFS‑60 mouse myelogenous leukemia lymphoblast cells. Nakoinz, I. et al. (1990) J. Immunol. 145:860. The ED₅₀ for this effect is 0.5‑3 ng/mL.

Scientific Data Examples for Recombinant Mouse M-CSF Protein

	Bioactivity of M-CSF Protein Recombinant Mouse M-CSF (416-ML) stimulates cell proliferation in the M-NFS-60 mouse myelogenous leukemia lymphoblast cell line in a dose-dependent manner. The ED₅₀ for this effect is 0.5-3 ng/mL.

Formulation, Preparation and Storage

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

416-ML

Carrier

Formulation	Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Reconstitution	Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping	The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage:	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

416-ML/CF

Carrier Free

Formulation	Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution	Reconstitute at 100 μg/mL in sterile PBS.
Shipping	The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage:	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: M-CSF

M-CSF, also known as CSF-1, is a four-alpha -helical-bundle cytokine that is the primary regulator of macrophage survival, proliferation and differentiation (1-3). M-CSF protein is also essential for the survival and proliferation of osteoclast progenitors (1, 4). M-CSF also primes and enhances macrophage killing of tumor cells and microorganisms, regulates the release of cytokines and other inflammatory modulators from macrophages, and stimulates pinocytosis (2, 3). M-CSF increases during pregnancy to support implantation and growth of the decidua and placenta (5). Sources of M-CSF include fibroblasts, activated macrophages, endometrial secretory epithelium, bone marrow stromal cells and activated endothelial cells (1-5). The M-CSF receptor (c-fms) transduces its pleotropic effects and mediates its endocytosis. M-CSF mRNAs of various sizes occur (3-9). Full length mouse M-CSF transcripts encode a 520 amino acid (aa) type I transmembrane (TM) protein with a 462 aa extracellular region, a 21 aa TM domain, and a 37 aa cytoplasmic tail that forms a 140 kDa covalent dimer. Differential processing produces two proteolytically cleaved, secreted dimers. One is an N- and O- glycosylated 86 kDa dimer, while the other is modified by both glycosylation and chondroitin-sulfate proteoglycan (PG) to generate a 200 kDa subunit. Although PG-modified M-CSF protein can circulate, it may be immobilized by attachment to type V collagen (8). Shorter transcripts encode M‑CSF that lacks cleavage and PG sites and produces an N-glycosylated 68 kDa TM dimer and a slowly produced 44 kDa secreted dimer (7). Although forms may vary in activity and half-life, all contain the N-terminal 150 aa portion that is necessary and sufficient for interaction with the M-CSF receptor (10, 11). The first 229 aa of mature mouse M-CSF shares 87%, 83%, 82% and 81% aa identity with corresponding regions of rat, dog, cow and human M-CSF, respectively (12, 13). Human M‑CSF is active in the mouse, but mouse M-CSF is reported to be species-specific.

Item	Value
References	Pixley, F.J. and E.R. Stanley (2004) Trends Cell Biol. 14:628. Chitu, V. and E.R. Stanley (2006) Curr. Opin. Immunol. 18:39. Fixe, P. and V. Praloran (1997) Eur. Cytokine Netw. 8:125. Ryan, G.R. et al. (2001) Blood 98:74. Makrigiannakis, A. et al. (2006) Trends Endocrinol. Metab. 17:178. Nandi, S. et al. (2006) Blood 107:786. Rettenmier, C.W. and M.F. Roussel (1988) Mol. Cell Biol. 8:5026. Suzu, S. et al. (1992) J. Biol. Chem. 267:16812. Manos, M.M. (1988) Mol. Cell. Biol. 8:5035. Koths, K. (1997) Mol. Reprod. Dev. 46:31. Jang, M-H. et al. (2006) J. Immunol. 177:4055. DeLamarter, J.F. et al. (1987) Nucleic Acids Res. 15:2389. Ladner, M.B. et al. (1988) Proc. Natl. Acad. Sci. USA 85:6706.
Long Name	Macrophage Colony Stimulating Factor
Entrez Gene IDs	1435 (Human); 12977 (Mouse)
Alternate Names	CSF-1, CSF1, Lanimostim, M-CSF, MCSF, MCSFlanimostim, MGC31930, colony stimulating factor 1 (macrophage), macrophage colony stimulating factor, macrophage colony-stimulating factor 1

Citations for Recombinant Mouse M-CSF Protein (531)

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Citations are publications that use Bio-Techne products. Selected citations for Recombinant Mouse M-CSF Protein include:

Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

JM Han et al. (2023), Polysaccharides from Annonaï¿½muricata leaves protect against cisplatin?induced cytotoxicity in macrophages by alleviating mitochondrial dysfunction Molecular Medicine Reports, 27(1).
PMID: 36453199
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

X Liu et al. (2022), Piperlongumine Inhibits Titanium Particles-Induced Osteolysis, Osteoclast Formation, and RANKL-Induced Signaling Pathways International Journal of Molecular Sciences, 23(5).
PMID: 35270008
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

SJ Hwang et al. (2022), miR-125a-5p attenuates macrophage-mediated vascular dysfunction by targeting Ninjurin1 Cell Death and Differentiation, 0(0).
PMID: 34974535
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

G Shen et al. (2022), Plumbagin is a NF-kappaB-Inducing Kinase Inhibitor with Dual Anabolic and Anti-Resorptive Effects that Prevents Menopausal-Related Osteoporosis in Mice The Journal of Biological Chemistry, 0(0):101767.
PMID: 35235833
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Q Guo et al. (2022), Mitochondrial pyruvate carrier blockade results in decreased osteoclastogenesis and bone resorption via regulating mitochondrial energy production The Journal of Biological Chemistry, 0(0):101775.
PMID: 35257748
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

H Zuo et al. (2022), Inhibition of myeloid PD-L1 suppresses osteoclastogenesis and cancer bone metastasis Cancer Gene Therapy, 0(0).
PMID: 35256753
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

C Yang et al. (2022), TET2 regulates osteoclastogenesis by modulating autophagy in OVX-induced bone loss Autophagy, 0(0).
PMID: 35255774
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

YJ Lee et al. (2022), Chemical Modulation of SQSTM1/p62-mediated Xenophagy that Targets a Broad Range of Pathogenic Bacteria Autophagy, 0(0).
PMID: 35316156
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

Y Ma et al. (2022), P2X7 receptor knockdown suppresses osteoclast differentiation by inhibiting autophagy and Ca2+/calcineurin signaling Molecular Medicine Reports, 25(5).
PMID: 35266012
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

ZI Mendel et al. (2022), Amino acids suppress macropinocytosis and promote release of CSF1 receptor in macrophages Journal of Cell Science, 0(0).
PMID: 35107133
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

KK Richardson et al. (2022), Ionizing Radiation Activates Mitochondrial Function in Osteoclasts and Causes Bone Loss in Young Adult Male Mice International Journal of Molecular Sciences, 23(2).
PMID: 35054859
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

V Mela et al. (2022), The Modulatory Effects of DMF on Microglia in Aged Mice Are Sex-Specific Cells, 11(4).
PMID: 35203379
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

Y Gao et al. (2022), Erythrocyte-derived extracellular vesicles aggravate inflammation by promoting the proinflammatory macrophage phenotype through TLR4-MyD88-NF-kappaB-MAPK pathway Journal of leukocyte biology, 0(0).
PMID: 35411633
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

W Yang et al. (2022), Epac1 activation by cAMP regulates cellular SUMOylation and promotes the formation of biomolecular condensates Science Advances, 8(16):eabm2960.
PMID: 35442725
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

G Li et al. (2022), 7-Ketocholesterol-Induced Micro-RNA-107-5p Increases Number and Activity of Osteoclasts by Targeting MKP1 International Journal of Molecular Sciences, 23(7).
PMID: 35409056
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

J Fierro et al. (2022), Dual-sgRNA CRISPR/Cas9 knockout of PD-L1 in human U87 glioblastoma tumor cells inhibits proliferation, invasion, and tumor-associated macrophage polarization Scientific Reports, 12(1):2417.
PMID: 35165339
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

W Qiao et al. (2022), Divalent metal cations stimulate skeleton interoception for new bone formation in mouse injury models Nature Communications, 13(1):535.
PMID: 35087048
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

JM Kim et al. (2022), Regulation of sclerostin by the SIRT1 stabilization pathway in osteocytes Cell Death and Differentiation, 0(0).
PMID: 35169297
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

T Akasaka et al. (2022), Osteoclast formation from mouse bone marrow cells on micro/nano-scale patterned surfaces Journal of oral biosciences, 0(0).
PMID: 35398598
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

H Tao et al. (2022), Gut Metabolite Urolithin A Inhibits Osteoclastogenesis and Senile Osteoporosis by Enhancing the Autophagy Capacity of Bone Marrow Macrophages Frontiers in Pharmacology, 13(0):875611.
PMID: 35645801
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

P Cai et al. (2022), Carnosol inhibits osteoclastogenesis inï¿½vivo and inï¿½vitro by blocking the RANKL?induced NF?kappaB signaling pathway Molecular Medicine Reports, 26(1).
PMID: 35593299
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

J Zhou et al. (2022), Peimine suppresses collagen-induced arthritis, activated fibroblast-like synoviocytes and TNFalpha-induced MAPK pathways International immunopharmacology, 111(0):109181.
PMID: 36027853
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

Y Inoue et al. (2022), Macrophage-Specific, Mafb-Deficient Mice Showed Delayed Skin Wound Healing International Journal of Molecular Sciences, 23(16).
PMID: 36012611
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

W Sun et al. (2022), Anoctamin 1 controls bone resorption by coupling Cl- channel activation with RANKL-RANK signaling transduction Nature Communications, 13(1):2899.
PMID: 35610255
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

X Chen et al. (2022), Mitochondria-targeted supramolecular coordination container encapsulated with exogenous itaconate for synergistic therapy of joint inflammation Theranostics, 12(7):3251-3272.
PMID: 35547753
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

H Qu et al. (2022), Transcriptomic Profiling Reveals That HMGB1 Induces Macrophage Polarization Different from Classical M1 Biomolecules, 12(6).
PMID: 35740904
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

M Jiang et al. (2022), Succinate and inosine coordinate innate immune response to bacterial infection PloS Pathogens, 18(8):e1010796.
PMID: 36026499
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Y Zhang et al. (2022), BHLHE40 promotes osteoclastogenesis and abnormal bone resorption via c-Fos/NFATc1 Cell bioscience, 2022;12(1):70.
PMID: 35619122
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

G Cai et al. (2022), Long noncoding RNA Gm31629 promotes bone regeneration by maintaining bone marrow mesenchymal stem cells activity PeerJ, 10(0):e13475.
PMID: 35702257
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Z Cui et al. (2022), Network Pharmacology Deciphers the Action of Bioactive Polypeptide in Attenuating Inflammatory Osteolysis via the Suppression of Oxidative Stress and Restoration of Bone Remodeling Balance Oxidative Medicine and Cellular Longevity, 2022(0):4913534.
PMID: 35578727
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

W Chen et al. (2022), A Novel Inhibitor INF 39 Promotes Osteogenesis via Blocking the NLRP3/IL-1beta Axis BioMed Research International, 2022(0):7250578.
PMID: 35872849
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

J Zhou et al. (2022), Mechanical force regulates root resorption in rats through RANKL and OPG BMC Oral Health, 22(1):290.
PMID: 35842599
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Z Jie et al. (2022), Pexmetinib suppresses osteoclast formation and breast cancer induced osteolysis via P38/STAT3 signal pathway Journal of Bone Oncology, 35(0):100439.
PMID: 35800294
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Y Wu et al. (2022), Multiepitope supramolecular peptide nanofibers eliciting coordinated humoral and cellular antitumor immune responses Science Advances, 8(29):eabm7833.
PMID: 35857833
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

J Zhang et al. (2022), LysM-positive neurons drive Tuberous Sclerosis Complex (TSC)-associated brain lesions Cellular Signalling, 0(0):110468.
PMID: 36115548
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

D Azimova et al. (2022), Cbp1, a fungal virulence factor under positive selection, forms an effector complex that drives macrophage lysis Oncogene, 18(6):e1010417.
PMID: 35731824
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

MI Alam et al. (2022), NLRP3 Inflammasome Negatively Regulates RANKL-Induced Osteoclastogenesis of Mouse Bone Marrow Macrophages but Positively Regulates It in the Presence of Lipopolysaccharides Oncogene, 23(11).
PMID: 35682777
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Y Tian et al. (2022), Melatonin inhibits osteoclastogenesis via RANKL/OPG suppression mediated by Rev-Erbalpha in osteoblasts Oncogene, 0(0).
PMID: 35726597
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

H Li et al. (2022), Trichinella spiralis cystatin alleviates polymicrobial sepsis through activating regulatory macrophages Oncogene, 109(0):108907.
PMID: 35691271
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

T Hoyler et al. (2022), Nonhematopoietic IRAK1 drives arthritis via neutrophil chemoattractants JCI Insight, 7(13).
PMID: 35801586
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

MH Wu et al. (2022), Inhibition of Neddylation Suppresses Osteoclast Differentiation and Function In Vitro and Alleviates Osteoporosis In Vivo Biomedicines, 10(10).
PMID: 36289618
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

J Zou et al. (2022), Interleukin-19 Promotes Retinal Neovascularization in a Mouse Model of Oxygen-Induced Retinopathy Investigative Ophthalmology Visual Science, 2022;63(8):9.
PMID: 35816041
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

M Tomimatsu et al. (2022), Myeloid cell-specific ablation of Runx2 gene exacerbates post-infarct cardiac remodeling Scientific Reports, 12(1):16656.
PMID: 36198906
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

AP Shaik et al. (2022), Detection of Radiolabeled Inflammatory Cell Macrophage Subpopulations in Chronic Respiratory Diseases: Results from Preliminary Analyses BioMed Research International, 2022(0):9470845.
PMID: 36246991
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

YF Wang et al. (2022), Regulation of CCL2 by EZH2 affects tumor-associated macrophages polarization and infiltration in breast cancer Cell Death Disease, 2022;13(8):748.
PMID: 36038549
Species: Mouse
Sample Types: Whole Cell

JX Sun et al. (2022), Activation of TRPV1 receptor facilitates myelin repair following demyelination via the regulation of microglial function Acta pharmacologica Sinica, 0(0).
PMID: 36229601
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

M Tsukasaki et al. (2022), Periosteal stem cells control growth plate stem cells during postnatal skeletal growth Oncogene, 13(1):4166.
PMID: 35851381
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Q Wang et al. (2022), Suppression of osteoclast multinucleation via a posttranscriptional regulation-based spatiotemporally selective delivery system Oncogene, 8(26):eabn3333.
PMID: 35767605
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

R Guo et al. (2022), Loss of MLKL ameliorates liver fibrosis by inhibiting hepatocyte necroptosis and hepatic stellate cell activation Theranostics, 12(11):5220-5236.
PMID: 35836819
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Z Hu et al. (2022), N6-methyladenosine of Socs1 modulates macrophage inflammatory response in different stiffness environments International journal of biological sciences, 18(15):5753-5769.
PMID: 36263168
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Q Li et al. (2022), HSC70 mediated autophagic degradation of oxidized PRL2 is responsible for osteoclastogenesis and inflammatory bone destruction Cell Death and Differentiation, 0(0).
PMID: 36182990
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

T Shi et al. (2022), Exercised accelerated the production of muscle-derived kynurenic acid in skeletal muscle and alleviated the postmenopausal osteoporosis through the Gpr35/NFkappaB p65 pathway Journal of Orthopaedic Translation, 35(0):1-12.
PMID: 35846727
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Y Cheng et al. (2022), Evaluation of culture conditions for osteoclastogenesis in RAW264.7 cells PLoS ONE, 17(11):e0277871.
PMID: 36395187
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

W Zhu et al. (2022), Myeloid TM6SF2 Deficiency Inhibits Atherosclerosis Cells, 11(18).
PMID: 36139452
Species: Transgenic Mouse
Sample Types: Whole Cells
Applications: Bioassay

CY Chang et al. (2022), Chronic exposure to carbon black ultrafine particles reprograms macrophage metabolism and accelerates lung cancer Science Advances, 8(46):eabq0615.
PMID: 36383649
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

X Sun et al. (2022), Mechanistic target of rapamycin complex 1 orchestrates the interplay between hepatocytes and Kupffer cells to determine the outcome of immune-mediated hepatitis Cell Death Disease, 2022;13(12):1031.
PMID: 36494334
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

C Lin et al. (2022), Impaired mitochondrial oxidative metabolism in skeletal progenitor cells leads to musculoskeletal disintegration Nature Communications, 13(1):6869.
PMID: 36369293
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

HK Kwon et al. (2022), Concurrent targeting of glycolysis in bacteria and host cell inflammation in septic arthritis Embo Molecular Medicine, 0(0):e15284.
PMID: 36354099
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

F Zhao et al. (2022), Brain milieu induces early microglial maturation through the BAX-Notch axis Nature Communications, 13(1):6117.
PMID: 36253375
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

JC Bahr et al. (2022), Divergent regulation of basement membrane trafficking by human macrophages and cancer cells Nature Communications, 13(1):6409.
PMID: 36302921
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

J Wang et al. (2022), Nanoparticle delivery of CD40 siRNA suppresses alloimmune responses by inhibiting activation and differentiation of DCs and macrophages Science Advances, 8(51):eabq3699.
PMID: 36542700
Species: Transgenic Mouse
Sample Types: Whole Cells
Applications: Bioassay

SMT Rahman et al. (2022), Double knockin mice show NF-kappaB trajectories in immune signaling and aging Cell Reports, 41(8):111682.
PMID: 36417863
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Y Chen et al. (2021), Schistosomaï¿½japonicum cystatin suppresses osteoclastogenesis via manipulating the NF?&kappaB signaling pathway Molecular Medicine Reports, 23(4).
PMID: 33576450
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

MG Dorrington et al. (2021), Type I IFNs facilitate innate immune control of the opportunistic bacteria Burkholderia cenocepacia in the macrophage cytosol PloS Pathogens, 17(3):e1009395.
PMID: 33684179
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

X Liu et al. (2021), Osteoclasts protect bone blood vessels against senescence through the angiogenin/plexin-B2 axis Nature Communications, 12(1):1832.
PMID: 33758201
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

S Huo et al. (2021), p300/CBP inhibitor A-485 inhibits the differentiation of osteoclasts and protects against osteoporotic bone loss International immunopharmacology, 94(0):107458.
PMID: 33626422
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

H Salo et al. (2021), Disulfide and Fully Reduced HMGB1 Induce Different Macrophage Polarization and Migration Patterns Biomolecules, 11(6).
PMID: 34071440
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

Q Lu et al. (2021), Patchouli Alcohol Modulates the Pregnancy X Receptor/Toll-like Receptor 4/Nuclear Factor Kappa B Axis to Suppress Osteoclastogenesis Frontiers in Pharmacology, 12(0):684976.
PMID: 34177594
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

J Yang et al. (2021), Astragalus polysaccharide attenuates LPS-related inflammatory osteolysis by suppressing osteoclastogenesis by reducing the MAPK signalling pathway Journal of Cellular and Molecular Medicine, 0(0).
PMID: 34080298
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

N Li et al. (2021), Inhibition of Sirtuin 3 prevents titanium particle-induced bone resorption and osteoclastsogenesis via suppressing ERK and JNK signaling International journal of biological sciences, 17(5):1382-1394.
PMID: 33867853
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

P Xue et al. (2021), Deficiency of optineurin enhances osteoclast differentiation by attenuating the NRF2-mediated antioxidant response Experimental Molecular Medicine, 2021;0(0).
PMID: 33864025
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

MJ Strowitzki et al. (2021), Inhibition of HIF-prolyl hydroxylases improves healing of intestinal anastomoses JCI Insight, 0(0).
PMID: 33784253
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

EB Byun et al. (2021), Protective Effect of Polysaccharides Extracted from Cudrania tricuspidata Fruit against Cisplatin-Induced Cytotoxicity in Macrophages and a Mouse Model International Journal of Molecular Sciences, 22(14).
PMID: 34299130
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

K Woo et al. (2021), N-3-Hydroxy Dodecanoyl-DL-homoserine Lactone (OH-dDHL) Triggers Apoptosis of Bone Marrow-Derived Macrophages through the ER- and Mitochondria-Mediated Pathways International Journal of Molecular Sciences, 22(14).
PMID: 34299184
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

KH Kim et al. (2021), BCG Cell Wall Skeleton As a Vaccine Adjuvant Protects Both Infant and Old-Aged Mice from Influenza Virus Infection Biomedicines, 9(5).
PMID: 34063125
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

JS Kim et al. (2021), Multi-Functional MPT Protein as a Therapeutic Agent against Mycobacterium tuberculosis Biomedicines, 9(5).
PMID: 34068051
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

K Wang et al. (2021), STING suppresses bone cancer pain via immune and neuronal modulation Nature Communications, 12(1):4558.
PMID: 34315904
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

X Guo et al. (2021), Bioinspired peptide adhesion on Ti implants alleviates wear particle-induced inflammation and improves interfacial osteogenesis Journal of colloid and interface science, 605(0):410-424.
PMID: 34332414
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

KH Nilsson et al. (2021), RSPO3 is important for trabecular bone and fracture risk in mice and humans Nature Communications, 12(1):4923.
PMID: 34389713
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

H Chen et al. (2021), Plastrum testudinis extract suppresses osteoclast differentiation via the NF-&kappaB signaling pathway and ameliorates senile osteoporosis Journal of ethnopharmacology, 276(0):114195.
PMID: 33974944
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

D Zhang et al. (2021), BMI1 regulates multiple myeloma-associated macrophage's pro-myeloma functions Cell Death Disease, 2021;12(5):495.
PMID: 33993198
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

DK Fix et al. (2021), Disrupted macrophage metabolic reprogramming in aged soleus muscle during early recovery following disuse atrophy Aging Cell, 0(0):e13448.
PMID: 34365717
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

OJ Sul et al. (2021), 7-ketocholesterol enhances autophagy via the ROS-TFEB signaling pathway in osteoclasts: 7-KC in osteoclasts The Journal of nutritional biochemistry, 0(0):108783.
PMID: 34023424
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

C Fang et al. (2021), Diterbutyl phthalate attenuates osteoarthritis in ACLT mice via suppressing ERK/c-fos/NFATc1 pathway, and subsequently inhibiting subchondral osteoclast fusion Acta pharmacologica Sinica, 0(0).
PMID: 34381182
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

L Janská et al. (2021), The MEMIC is an ex vivo system to model the complexity of the tumor microenvironment Disease Models Mechanisms, 2021;14(8).
PMID: 34407185
Species: Mouse
Sample Types: Whole Cells
Applications: Differentiation

JM Motta et al. (2021), Tumor-Released Products Promote Bone Marrow-Derived Macrophage Survival and Proliferation Biomedicines, 9(10).
PMID: 34680504
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

CR Park et al. (2021), Rufomycin Exhibits Dual Effects Against Mycobacterium abscessus Infection by Inducing Host Defense and Antimicrobial Activities Frontiers in Microbiology, 12(0):695024.
PMID: 34447358
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

S Jiang et al. (2021), Proteopathic tau primes and activates interleukin-1beta via myeloid-cell-specific MyD88- and NLRP3-ASC-inflammasome pathway Cell Reports, 36(12):109720.
PMID: 34551296
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

JA Carroll et al. (2021), Innate immune responses after stimulation with Toll-like receptor agonists in ex vivo microglial cultures and an in vivo model using mice with reduced microglia Journal of Neuroinflammation, 18(1):194.
PMID: 34488805
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

SN Cho et al. (2021), Ang II-Induced Hypertension Exacerbates the Pathogenesis of Tuberculosis Cells, 10(9).
PMID: 34572127
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

C Liu et al. (2021), Danlou Tablets Inhibit Atherosclerosis in Apolipoprotein E-Deficient Mice by Inducing Macrophage Autophagy: The Role of the PI3K-Akt-mTOR Pathway Frontiers in Pharmacology, 12(0):724670.
PMID: 34566648
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

IY Karkache et al. (2021), Myeloid Lineage Ablation of Phlpp1 Regulates M-CSF Signaling and Tempers Bone Resorption in Female Mice International Journal of Molecular Sciences, 22(18).
PMID: 34575866
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

H Muto et al. (2021), Conditioned medium from stem cells derived from human exfoliated deciduous teeth ameliorates NASH via the Gut-Liver axis Scientific Reports, 11(1):18778.
PMID: 34548598
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

M Mae et al. (2021), The Role of Cytokines Produced via the NLRP3 Inflammasome in Mouse Macrophages Stimulated with Dental Calculus in Osteoclastogenesis International Journal of Molecular Sciences, 22(22).
PMID: 34830316
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

J Gu et al. (2021), Galectin-3 Contributes to the Inhibitory Effect of lalpha,25-(OH)2D3 on Osteoclastogenesis International Journal of Molecular Sciences, 22(24).
PMID: 34948130
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Y Zou et al. (2021), SIRT6 inhibition delays peripheral nerve recovery by suppressing migration, phagocytosis and M2-polarization of macrophages Cell bioscience, 2021;11(1):210.
PMID: 34906231
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

C Zhuang et al. (2021), Jintiange Capsules Ameliorate Osteoarthritis by Modulating Subchondral Bone Remodeling and Protecting Cartilage Against Degradation Frontiers in Pharmacology, 12(0):762543.
PMID: 34858187
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

J Amo-Aparic et al. (2021), Interleukin-4 and interleukin-13 induce different metabolic profiles in microglia and macrophages that relate with divergent outcomes after spinal cord injury Theranostics, 11(20):9805-9820.
PMID: 34815787
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Z Liu et al. (2021), CNC-bZIP protein NFE2L1 regulates osteoclast differentiation in antioxidant-dependent and independent manners Redox Biology, 48(0):102180.
PMID: 34763297
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

E Kim et al. (2021), TM4SF5-dependent crosstalk between hepatocytes and macrophages to reprogram the inflammatory environment Cell Reports, 37(7):110018.
PMID: 34788612
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

AE Hinman et al. (2021), Mycobacterium tuberculosis canonical virulence factors interfere with a late component of the TLR2 response Elife, 10(0).
PMID: 34755600
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

SW Shin et al. (2021), Anti-Periodontitis Effect of Ethanol Extracts of Alpinia Katsumadai Seeds Nutrients, 14(1).
PMID: 35011011
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Y Fang et al. (2021), Bortezomib Rescues Ovariectomy-Induced Bone Loss via SMURF-Mediated Ubiquitination Pathway Oxidative Medicine and Cellular Longevity, 2021(0):9661200.
PMID: 35003523
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

MB Uccellini et al. (2021), Development of a Macrophage-Based ADCC Assay Vaccines, 9(6).
PMID: 34204268
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Y Zhang et al. (2021), ULK1 Suppresses Osteoclast Differentiation and Bone Resorption via Inhibiting Syk-JNK through DOK3 Oxidative Medicine and Cellular Longevity, 2021(0):2896674.
PMID: 34820053
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Y Liang et al. (2021), PP2Ac&alpha promotes macrophage accumulation and activation to exacerbate tubular cell death and kidney fibrosis through activating Rap1 and TNF&alpha production Cell Death and Differentiation, 0(0).
PMID: 33934104
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

TT Chu et al. (2021), Tonic prime-boost of STING signalling mediates Niemann-Pick disease type C Nature, 0(0).
PMID: 34290407
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

M Kawakami et al. (2021), Development of a method for the identification of receptor activator of nuclear factor-&kappaB+ populations in vivo Journal of oral biosciences, 0(0).
PMID: 33516894
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

RD Hu et al. (2021), Chromatin accessibility analysis identifies the transcription factor ETV5 as a suppressor of adipose tissue macrophage activation in obesity Cell Death Disease, 2021;12(11):1023.
PMID: 34716308
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

AS Tooley et al. (2021), The innate immune kinase TBK1 directly increases mTORC2 activity and downstream signaling to Akt The Journal of Biological Chemistry, 0(0):100942.
PMID: 34245780
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

MG Dorrington et al. (2021), Correction: Type I IFNs facilitate innate immune control of the opportunistic bacteria Burkholderia cenocepacia in the macrophage cytosol PloS Pathogens, 17(8):e1009821.
PMID: 34347853
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

JS Brunner et al. (2020), Environmental arginine controls multinuclear giant cell metabolism and formation Nat Commun, 11(1):431.
PMID: 31969567
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: Cell Culture

JR Plemel et al. (2020), Microglia response following acute demyelination is heterogeneous and limits infiltrating macrophage dispersion Sci Adv, 6(3):eaay6324.
PMID: 31998844
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

P Saha et al. (2020), Distinct iron homeostasis in C57BL/6 and Balb/c mouse strains Physiol Rep, 8(9):e14441.
PMID: 32385968
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

Y Kohara et al. (2020), Hedgehog Inhibitors Suppress Osteoclastogenesis in In Vitro Cultures, and Deletion of Smo in Macrophage/Osteoclast Lineage Prevents Age-Related Bone Loss Int J Mol Sci, 21(8).
PMID: 32326611
Species: Mouse

Applications: In Vivo

Z Hu et al. (2020), CNTF-STAT3-IL-6 Axis Mediates Neuroinflammatory Cascade across Schwann Cell-Neuron-Microglia Cell Rep, 31(7):107657.
PMID: 32433966
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

JM Kim et al. (2020), A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation Nat Commun, 11(1):2289.
PMID: 32385263
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Y Huang et al. (2020), Myeloid PTEN promotes chemotherapy-induced NLRP3-inflammasome activation and antitumour immunity Nat. Cell Biol., 0(0).
PMID: 32367047
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

NL Mancini et al. (2020), Perturbed mitochondrial dynamics is a novel feature of colitis that can be targeted to lessen disease Cell Mol Gastroenterol Hepatol, 0(0).
PMID: 32298841
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay

H Fan et al. (2020), MsrA Suppresses Inflammatory Activation of Microglia and Oxidative Stress to Prevent Demyelination via Inhibition of the NOX2-MAPKs/NF-&kappaB Signaling Pathway Drug Des Devel Ther, 14(0):1377-1389.
PMID: 32308370
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

SG Rotman et al. (2020), Development of bone seeker-functionalised microspheres as a targeted local antibiotic delivery system for bone infections J Orthop Translat, 21(0):136-145.
PMID: 32309139
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

X Sun et al. (2020), Pregnenolone Inhibits Osteoclast Differentiation and Protects Against Lipopolysaccharide-Induced Inflammatory Bone Destruction and Ovariectomy-Induced Bone Loss Front Pharmacol, 11(0):360.
PMID: 32292342
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Z Sun et al. (2020), Magnoflorine Suppresses MAPK and NF-&kappaB Signaling to Prevent Inflammatory Osteolysis Induced by Titanium Particles In Vivo and Osteoclastogenesis via RANKL In Vitro Front Pharmacol, 11(0):389.
PMID: 32300300
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

X Hu et al. (2020), Tussilagone Inhibits Osteoclastogenesis and Periprosthetic Osteolysis by Suppressing the NF-&kappaB and P38 MAPK Signaling Pathways Front Pharmacol, 11(0):385.
PMID: 32317967
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

JA Carroll et al. (2020), Prion protein N1 cleavage peptides stimulate microglial interaction with surrounding cells Sci Rep, 10(1):6654.
PMID: 32313035
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

JS Suh et al. (2020), Rosuvastatin Prevents the Exacerbation of Atherosclerosis in Ligature-Induced Periodontal Disease Mouse Model Sci Rep, 10(1):6383.
PMID: 32286430
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Y Zhang et al. (2020), F2r negatively regulates osteoclastogenesis through inhibiting the Akt and NF&kappaB signaling pathways Int. J. Biol. Sci., 16(9):1629-1639.
PMID: 32226307
Species: Mouse
Sample Types: Whole Cell
Applications: Bioassay

E van den Bo et al. (2020), Knockout mouse models reveal the contributions of G protein subunits to complement C5a receptor-mediated chemotaxis J. Biol. Chem., 0(0).
PMID: 32332099
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

C Goda et al. (2020), Loss of FOXM1 in macrophages promotes pulmonary fibrosis by activating p38 MAPK signaling pathway PLoS Genet., 16(4):e1008692.
PMID: 32271749
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

HS Park et al. (2020), Mycobacterium avium subsp. paratuberculosis MAP1889c Protein Induces Maturation of Dendritic Cells and Drives Th2-biased Immune Responses Cells, 9(4).
PMID: 32290379
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

W Wu et al. (2020), CD39 Produced from Human GMSCs Regulates the Balance of Osteoclasts and Osteoblasts through the Wnt/&beta-Catenin Pathway in Osteoporosis Mol. Ther., 0(0).
PMID: 32304668
Species: Mouse
Sample Types: N/A

MB Uccellini et al. (2020), Passenger Mutations Confound Phenotypes of SARM1-Deficient Mice Cell Rep, 31(1):107498.
PMID: 32268088
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

KS Shim et al. (2020), Water Extract of Lysimachia christinae Inhibits Trabecular Bone Loss and Fat Accumulation in Ovariectomized Mice Nutrients, 12(7).
PMID: 32610585
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

Y Tsuchiya et al. (2020), The key royal jelly component 10-hydroxy-2-decenoic acid protects against bone loss by inhibiting NF-&kappaB signaling downstream of FFAR4 J. Biol. Chem., 0(0).
PMID: 32647011
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

H Chen et al. (2020), Neobavaisoflavone inhibits osteoclastogenesis through blocking RANKL signalling-mediated TRAF6 and c-Src recruitment and NF-&kappaB, MAPK and Akt pathways J. Cell. Mol. Med., 0(0).
PMID: 32604472
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

P Xu et al. (2020), Role of microglia in the dissemination of Zika virus from mother to fetal brain PLoS Negl Trop Dis, 14(7):e0008413.
PMID: 32628667
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

JH Kang et al. (2020), Dual role of phosphatidylserine and its receptors in osteoclastogenesis Cell Death Dis, 11(7):497.
PMID: 32612123
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

M Chen et al. (2020), Substrate stiffness modulates bone marrow-derived macrophage polarization through NF-&kappaB signaling pathway Bioact Mater, 5(4):880-890.
PMID: 32637751
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

T Velletri et al. (2020), Loss of p53 in mesenchymal stem cells promotes alteration of bone remodeling through negative regulation of osteoprotegerin Cell Death Differ., 0(0).
PMID: 32694652
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

K Maruyama et al. (2020), Zinc Finger Protein St18 Protects against Septic Death by Inhibiting VEGF-A from Macrophages Cell Rep, 32(2):107906.
PMID: 32668247
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

YR Kim et al. (2020), Identification of highly potent and selective inhibitor, TIPTP, of the p22phox-Rubicon axis as a therapeutic agent for rheumatoid arthritis Sci Rep, 10(1):4570.
PMID: 32165681
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

X Zhi et al. (2020), Guaiacol suppresses osteoclastogenesis by blocking interactions of RANK with TRAF6 and C-Src and inhibiting NF-&kappaB, MAPK and AKT pathways J. Cell. Mol. Med., 0(0).
PMID: 32185887
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

L Wang et al. (2020), Osthole-loaded N-octyl-O-sulfonyl chitosan micelles (NSC-OST) inhibits RANKL-induced osteoclastogenesis and prevents ovariectomy-induced bone loss in rats J. Cell. Mol. Med., 0(0).
PMID: 32126148
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

YS Kim et al. (2020), The Peroxisome Proliferator-Activated Receptor &alpha- Agonist Gemfibrozil Promotes Defense Against Mycobacterium abscessus Infections Cells, 9(3).
PMID: 32155958
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

MS Ferguson et al. (2020), Transient Inhibition of PI3K&delta Enhances the Therapeutic Effect of Intravenous Delivery of Oncolytic Vaccinia Virus Mol. Ther., 0(0).
PMID: 32145202
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

H Zuo et al. (2020), Differential regulation of breast cancer bone metastasis by PARP1 and PARP2 Nat Commun, 11(1):1578.
PMID: 32221289
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

N Uesato et al. (2020), Pharmacological Properties of JTE-952, an Orally Available and Selective Colony Stimulating Factor 1 Receptor Kinase Inhibitor Biol. Pharm. Bull., 43(2):325-333.
PMID: 32009119
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

FQ Kong et al. (2020), Macrophage MSR1 promotes the formation of foamy macrophage and neuronal apoptosis after spinal cord injury J Neuroinflammation, 17(1):62.
PMID: 32066456
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

D Zhang et al. (2020), Knockdown of Tcirg1 inhibits large-osteoclast generation by down-regulating NFATc1 and IP3R2 expression PLoS ONE, 15(8):e0237354.
PMID: 32790690
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

S Rosendahl et al. (2020), CCR3 deficiency is associated with increased osteoclast activity and reduced cortical bone volume in adult male mice The Journal of Biological Chemistry, 0(0).
PMID: 33303631
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

X Tong et al. (2020), Overexpression of c-Fos reverses osteoprotegerin-mediated suppression of osteoclastogenesis by increasing the Beclin1-induced autophagy Journal of Cellular and Molecular Medicine, 0(0).
PMID: 33277741
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Y Liu et al. (2020), Maackiain dampens osteoclastogenesis via attenuating RANKL-stimulated NF-&kappaB signalling pathway and NFATc1 activity J. Cell. Mol. Med., 0(0).
PMID: 32939977
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

DHH Molstad et al. (2020), Hdac3 regulates bone modeling by suppressing osteoclast responsiveness to RANKL J Biol Chem, 0(0).
PMID: 33012705
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

AT Holdbrooks et al. (2020), Regulation of inflammatory signaling by the ST6Gal-I sialyltransferase PLoS ONE, 15(11):e0241850.
PMID: 33166339
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

N Hagan et al. (2020), CSF1R signaling is a regulator of pathogenesis in progressive MS Cell Death Dis, 11(10):904.
PMID: 33097690
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

T Okui et al. (2020), The HMGB1/RAGE axis induces bone pain associated with colonization of 4T1 mouse breast cancer in bone Journal of Bone Oncology, 26(0):100330.
PMID: 33204606
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

L Wang et al. (2020), Dopamine suppresses osteoclast differentiation via cAMP/PKA/CREB pathway Cell Signal, 78(0):109847.
PMID: 33242564
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

JS Kim et al. (2020), Toxoplasma gondii GRA9 Regulates the Activation of NLRP3 Inflammasome to Exert Anti-Septic Effects in Mice Int J Mol Sci, 21(22).
PMID: 33182702
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

L Xiao et al. (2020), Puerarin alleviates osteoporosis in the ovariectomy-induced mice by suppressing osteoclastogenesis via inhibition of TRAF6/ROS-dependent MAPK/NF-&kappaB signaling pathways Aging (Albany NY), 12(21):21706-21729.
PMID: 33176281
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

B Chu et al. (2020), Nepetin inhibits osteoclastogenesis by inhibiting RANKL-induced activation of NF-&kappaB and MAPK signalling pathway, and autophagy J Cell Mol Med, 0(0).
PMID: 33135301
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

S Yonebayash et al. (2020), MAIR-II deficiency ameliorates cardiac remodelling post-myocardial infarction by suppressing TLR9-mediated macrophage activation J Cell Mol Med, 0(0).
PMID: 33140535
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

MJ Park et al. (2020), Myeloid-derived suppressor cells therapy enhance immunoregulatory properties in acute graft versus host disease with combination of regulatory T cells Journal of Translational Medicine, 18(1):483.
PMID: 33317573
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

CH Lee et al. (2020), NLRP3 Inflammasome Activation Is Involved in LPA1-Mediated Brain Injury after Transient Focal Cerebral Ischemia Int J Mol Sci, 21(22).
PMID: 33202644
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Z Najafova et al. (2020), RNF40 exerts stage-dependent functions in differentiating osteoblasts and is essential for bone cell crosstalk Cell Death Differ., 0(0).
PMID: 32901120
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

G Yang et al. (2020), Pik3c3 deficiency in myeloid cells imparts partial resistance to experimental autoimmune encephalomyelitis associated with reduced IL-1&beta production Cell Mol Immunol, 0(0).
PMID: 33235386
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

Y Yang et al. (2020), M2 macrophage-derived exosomes promote angiogenesis and growth of pancreatic ductal adenocarcinoma by targeting E2F2 Mol Ther, 0(0).
PMID: 33221435
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

YS Lee et al. (2020), Regulation of bone metabolism by megakaryocytes in a paracrine manner Sci Rep, 10(1):2277.
PMID: 32042021
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

TT Tang et al. (2020), Extracellular vesicle-encapsulated IL-10 as novel nanotherapeutics against ischemic AKI Sci Adv, 6(33):eaaz0748.
PMID: 32851154
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

J Peng et al. (2020), Sarsasapogenin Suppresses RANKL-Induced Osteoclastogenesis in vitro and Prevents Lipopolysaccharide-Induced Bone Loss in vivo Drug Des Devel Ther, 14(0):3435-3447.
PMID: 32943842
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

S Ikezu et al. (2020), Inhibition of colony stimulating factor 1 receptor corrects maternal inflammation-induced microglial and synaptic dysfunction and behavioral abnormalities Mol. Psychiatry, 0(0).
PMID: 32071385
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

ME McCauley et al. (2020), C9orf72 in myeloid cells suppresses STING-induced inflammation Nature, 585(7823):96-101.
PMID: 32814898
G Gupta et al. (2020), The Long Pentraxin 3 (PTX3) Suppresses Immunity to Cutaneous Leishmaniasis by Regulating CD4+ T Helper Cell Response Cell Reports, 33(11):108513.
PMID: 33326783
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

RK Arya et al. (2020), Mechanotransduction via a TRPV4-Rac1 signaling axis plays a role in multinucleated giant cell formation The Journal of Biological Chemistry, 296(0):100129.
PMID: 33460921
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

L Liu et al. (2020), Progranulin inhibits LPS-induced macrophage M1 polarization via NF-?B and MAPK pathways BMC Immunol., 21(1):32.
PMID: 32503416
Species: Transgenic Mouse
Sample Types: Spheroid
Applications: Bioassay

AE Engler et al. (2020), Airway-Associated Macrophages in Homeostasis and Repair Cell Reports, 33(13):108553.
PMID: 33378665
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

K Wang et al. (2020), PD-1 blockade inhibits osteoclast formation and murine bone cancer pain J. Clin. Invest., 0(0).
PMID: 32484460
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

K Miyagawa et al. (2020), Osteoclast-derived IGF1 is required for pagetic lesion formation in vivo JCI Insight, 0(0).
PMID: 32078587
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

G Cerrato et al. (2020), Oleate-induced aggregation of LC3 at the trans-Golgi network is linked to a protein trafficking blockade Cell Death and Differentiation, 0(0).
PMID: 33335289
Species: Feline
Sample Types: Whole Cells
Applications: Cell Culture

S Lee et al. (2020), Transcriptomic profiling of feline teeth highlights the role of matrix metalloproteinase 9 (MMP9) in tooth resorption Sci Rep, 10(1):18958.
PMID: 33144645
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

H Liu et al. (2020), NR1D1 modulates synovial inflammation and bone destruction in rheumatoid arthritis Cell Death Dis, 11(2):129.
PMID: 32071294
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

SY Kim et al. (2020), Mycobacterium tuberculosis Rv2626c-derived peptide as a therapeutic agent for sepsis Embo Molecular Medicine, 12(12):e12497.
PMID: 33258196
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

M Timmen et al. (2020), The heparan sulfate proteoglycan Syndecan-1 influences local bone cell communication via the RANKL/OPG axis Sci Rep, 10(1):20510.
PMID: 33239699
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

Z Liu et al. (2020), Tetrandrine Inhibits Titanium Particle-Induced Inflammatory Osteolysis through the Nuclear Factor-&kappaB Pathway Mediators of Inflammation, 2020(0):1926947.
PMID: 33312069
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

BH Zou et al. (2020), Oridonin ameliorates inflammation-induced bone loss in mice via suppressing DC-STAMP expression Acta Pharmacol. Sin., 0(0).
PMID: 32753731
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

HT Pham et al. (2020), Collagen VIalpha2 chain deficiency causes trabecular bone loss by potentially promoting osteoclast differentiation through enhanced TNFalpha signaling Sci Rep, 10(1):13749.
PMID: 32792616
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Z Qian et al. (2020), Cytisine attenuates bone loss of ovariectomy mouse by preventing RANKL-induced osteoclastogenesis J. Cell. Mol. Med., 0(0).
PMID: 32790170
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

J Wang et al. (2020), Tectoridin inhibits osteoclastogenesis and bone loss in a murine model of ovariectomy-induced osteoporosis Exp. Gerontol., 140(0):111057.
PMID: 32798609
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

SJ Moon et al. (2020), Ablation of Gadd45beta ameliorates the inflammation and renal fibrosis caused by unilateral ureteral obstruction J. Cell. Mol. Med., 0(0).
PMID: 32570293
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

D Zhang et al. (2020), Knockdown of Tcirg1 inhibits large-osteoclast generation by down-regulating NFATc1 and IP3R2 expression PLoS ONE, 15(8):e0237354.
PMID: 32790690
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Y Chen et al. (2020), Dendritic cells-derived interferon-lambda1 ameliorated inflammatory bone destruction through inhibiting osteoclastogenesis Cell Death Dis, 11(6):414.
PMID: 32488049
Species: Mouse Mouse
Sample Types: Whole Cells
Applications: Bioassay

ME McCauley et al. (2020), C9orf72 in myeloid cells suppresses STING-induced inflammation Nature, 585(7823):96-101.
PMID: 32814898
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

YW Ge et al. (2020), The Recombinant Protein EphB4-Fc Changes the Ti Particle-Mediated Imbalance of OPG/RANKL via EphrinB2/EphB4 Signaling Pathway and Inhibits the Release of Proinflammatory Factors In Vivo Oxid Med Cell Longev, 2020(0):1404915.
PMID: 32587656
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

L Zhang et al. (2020), Genetic and pharmacological activation of Hedgehog signaling inhibits osteoclastogenesis and attenuates titanium particle-induced osteolysis partly through suppressing the JNK/c-Fos-NFATc1 cascade Theranostics, 10(15):6638-6660.
PMID: 32550895
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

H Cui et al. (2019), Long noncoding RNA Malat1 regulates differential activation of macrophage and response to lung injury JCI Insight, 0(0).
PMID: 30676324
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

CL Chan et al. (2019), L-caldesmon alters cell spreading and adhesion force in RANKL-induced osteoclasts J. Biomed. Sci., 26(1):12.
PMID: 30678675
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

NKY Wee et al. (2019), Skeletal phenotype of the neuropeptide Y knockout mouse Neuropeptides, 73(0):78-88.
PMID: 30522780
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

S Murugan et al. (2019), The neurosteroid, pregnenolone promotes degradation of key proteins in the innate immune signalling to suppress inflammation J. Biol. Chem., 0(0).
PMID: 30647133
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

X Rao et al. (2019), Oxidized LDL upregulates macrophage DPP4 expression via TLR4/TRIF/CD36 pathways EBioMedicine, 0(0).
PMID: 30738832
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

M Ahn et al. (2019), Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host Nat Microbiol, 0(0).
PMID: 30804542
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

B Zhu et al. (2019), CD200 Modulates S. aureus-Induced Innate Immune Responses Through Suppressing p38 Signaling Int J Mol Sci, 20(3).
PMID: 30717437
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

V Aguayo et al. (2019), Fasciola hepatica GST downregulates NF-?B pathway effectors and inflammatory cytokines while promoting survival in a mouse septic shock model Sci Rep, 9(1):2275.
PMID: 30783117
Species: Mouse

Applications: Bioassay

Q Sun et al. (2019), A potential therapeutic target for regulating osteoporosis via suppression of osteoclast differentiation J Dent, 0(0).
PMID: 30716449
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

H Jin et al. (2019), Evodiamine inhibits RANKL-induced osteoclastogenesis and prevents ovariectomy-induced bone loss in mice J. Cell. Mol. Med., 23(1):522-534.
PMID: 30451360
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

TS Kim et al. (2019), SIRT3 promotes antimycobacterial defenses by coordinating mitochondrial and autophagic functions Autophagy, 0(0):20-Jan.
PMID: 30774023
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

A Bergsma et al. (2019), Regulation of cytoskeleton and adhesion signaling in osteoclasts by tetraspanin CD82 Bone Rep, 10(0):100196.
PMID: 30788390
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

P Handa et al. (2019), Iron alters macrophage polarization status and leads to steatohepatitis and fibrogenesis J. Leukoc. Biol., 0(0).
PMID: 30835899
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

S Paik et al. (2019), Rg6, a rare ginsenoside, inhibits systemic inflammation through the induction of interleukin-10 and microRNA-146a Sci Rep, 9(1):4342.
PMID: 30867482
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

J Lee et al. (2019), Characterisation of genes differentially expressed in macrophages by virulent and attenuated Mycobacterium tuberculosis through RNA-Seq analysis Sci Rep, 9(1):4027.
PMID: 30858471
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

N Funk et al. (2019), The Parkinson's disease-linked Leucine-rich repeat kinase 2 (LRRK2) is required for insulin-stimulated translocation of GLUT4 Sci Rep, 9(1):4515.
PMID: 30872638
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

HS Park et al. (2019), Mycobacterium tuberculosis Rv3463 induces mycobactericidal activity in macrophages by enhancing phagolysosomal fusion and exhibits therapeutic potential Sci Rep, 9(1):4246.
PMID: 30862819
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

J Wang et al. (2019), Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy Nat. Med., 0(0).
PMID: 30833750
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

R Singh et al. (2019), Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway Nat Commun, 10(1):89.
PMID: 30626868
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

NS Adapala et al. (2019), PI3K activation increases SDF-1 production and number of osteoclast precursors, and enhances SDF-1-mediated osteoclast precursor migration Bone Rep, 10(0):100203.
PMID: 30989092
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

C Zhao et al. (2019), Discovery of new inhibitors against both NF-?B and osteoclastogenesis from in-house library with ?, ?-unsaturated-enone fragment Bioorg. Chem., 87(0):638-646.
PMID: 30947099
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

HK Kwon et al. (2019), A cell-penetrating peptide blocks Toll-like receptor-mediated downstream signaling and ameliorates autoimmune and inflammatory diseases in mice Exp. Mol. Med., 51(4):50.
PMID: 31028244
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

NE Putnam et al. (2019), MyD88 and IL-1R signaling drive antibacterial immunity and osteoclast-driven bone loss during Staphylococcus aureus osteomyelitis PLoS Pathog., 15(4):e1007744.
PMID: 30978245
Species: Mouse
Sample Types: Tumor Cells
Applications: Bioassay

Z Kun et al. (2019), Tumor derived EDIL3 modulates the expansion and osteoclastogenesis of myeloid derived suppressor cells in murine breast cancer model J Bone Oncol, 16(0):100238.
PMID: 31110935
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

SW Wong et al. (2019), Global deletion of Optineurin results in altered type I IFN signaling and abnormal bone remodeling in a model of Paget's disease Cell Death Differ., 0(0).
PMID: 31076632
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

LL Lv et al. (2019), Exosomal miRNA-19b-3p of tubular epithelial cells promotes M1 macrophage activation in kidney injury Cell Death Differ., 0(0).
PMID: 31097789
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

S Lotinun et al. (2019), Cathepsin K-deficient osteocytes prevent lactation-induced bone loss and parathyroid hormone suppression J. Clin. Invest., 130(0).
PMID: 31112135
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

K Tsuchiya et al. (2019), Caspase-1 initiates apoptosis in the absence of gasdermin D Nat Commun, 10(1):2091.
PMID: 31064994
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

J Meng et al. (2019), Stachydrine prevents LPS-induced bone loss by inhibiting osteoclastogenesis via NF-ÎºB and Akt signalling J. Cell. Mol. Med., 0(0).
PMID: 31328430
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

J Mei et al. (2019), Nerve modulation therapy in gouty arthritis: targeting increased sFRP2 expression in dorsal root ganglion regulates macrophage polarization and alleviates endothelial damage Theranostics, 9(13):3707-3722.
PMID: 31281508
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

YS Yang et al. (2019), Bone-targeting AAV-mediated silencing of Schnurri-3 prevents bone loss in osteoporosis Nat Commun, 10(1):2958.
PMID: 31273195
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

L Sun et al. (2019), Propofol directly induces caspase-1-dependent macrophage pyroptosis through the NLRP3-ASC inflammasome Cell Death Dis, 10(8):542.
PMID: 31316052
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

D Xiong et al. (2019), Salmonella Coiled-Coil- and TIR-Containing TcpS Evades the Innate Immune System and Subdues Inflammation Cell Rep, 28(3):804-818.e7.
PMID: 31315056
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

SS Dykes et al. (2019), Cathepsin L secretion by host and neoplastic cells potentiates invasion Oncotarget, 10(53):5560-5568.
PMID: 31565189
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

WS Lian et al. (2019), MicroRNA-29a represses osteoclast formation and protects against osteoporosis by regulating PCAF-mediated RANKL and CXCL12 Cell Death Dis, 10(10):705.
PMID: 31543513
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

X Sun et al. (2019), The Nrf2 activator RTA-408 attenuates osteoclastogenesis by inhibiting STING dependent NF-?b signaling Redox Biol, 28(0):101309.
PMID: 31487581
Species: Mouse
Sample Types: Whole Cells
Applications: Differentiation

S Nair et al. (2019), Adult stem cell deficits drive Slc29a3 disorders in mice Nat Commun, 10(1):2943.
PMID: 31270333
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

Y Wang et al. (2019), Nobiletin-loaded micelles reduce ovariectomy-induced bone loss by suppressing osteoclastogenesis Int J Nanomedicine, 14(0):7839-7849.
PMID: 31576127
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

S Avasarala et al. (2019), PRMT6 promotes lung tumor progression via the alternate activation of tumor-associated macrophages Mol. Cancer Res., 0(0).
PMID: 31619507
Species: Mouse
Sample Types: Cell Lysates
Applications: Cell Culture

RW Wu et al. (2019), MicroRNA-29a Counteracts Glucocorticoid Induction of Bone Loss through Repressing TNFSF13b Modulation of Osteoclastogenesis Int J Mol Sci, 20(20).
PMID: 31627291
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

N Wu et al. (2019), The interferon stimulated gene 20 protein (ISG20) is an innate defense antiviral factor that discriminates self versus non-self translation PLoS Pathog., 15(10):e1008093.
PMID: 31600344
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

K Newton et al. (2019), Cleavage of RIPK1 by caspase-8ï¿½is crucial for limiting apoptosis and necroptosis Nature, 0(0).
PMID: 31511692
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

J Nagai et al. (2019), P2Y6 signaling in alveolar macrophages prevents leukotriene-dependent type 2 allergic lung inflammation J. Clin. Invest., 0(0).
PMID: 31638598
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

AL Rocha et al. (2019), Inhibitory effects of dabigatran etexilate, a direct thrombin inhibitor, on osteoclasts and osteoblasts Thromb. Res., 186(0):45-53.
PMID: 31883999
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

SK Pore et al. (2019), A Novel Sulforaphane-Regulated Gene Network in Suppression of Breast Cancer-Induced Osteolytic Bone Resorption Mol. Cancer Ther., 0(0).
PMID: 31784454
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

J Hu et al. (2019), The protective effect of WKYMVm peptide on inflammatory osteolysis through regulating NF-kappaB and CD9/gp130/STAT3 signalling pathway J. Cell. Mol. Med., 0(0).
PMID: 31837208
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

A El-Kenawi et al. (2019), Acidity promotes tumour progression by altering macrophage phenotype in prostate cancer Br. J. Cancer, 121(7):556-566.
PMID: 31417189
Species: Mouse
Sample Types: Whole Tissue
Applications: Tissue Culture

AE Ciecko et al. (2019), Interleukin-27 Is Essential for Type 1 Diabetes Development and Sjï¿½gren Syndrome-like Inflammation Cell Rep, 29(10):3073-3086.e5.
PMID: 31801074
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

D Huang et al. (2019), Diterpenoids from the aerial parts of Flueggea acicularis and their activity against RANKL-induced osteoclastogenesis Bioorg. Chem., 0(0):103453.
PMID: 31787342
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

J Wang et al. (2019), Phillyrin Attenuates Osteoclast Formation and Function and Prevents LPS-Induced Osteolysis in Mice Front Pharmacol, 10(0):1188.
PMID: 31680965
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

SV Novitskiy et al. (2019), Gas6/MerTK signaling is negatively regulated by NF-&kappaB and supports lung carcinogenesis Oncotarget, 10(66):7031-7042.
PMID: 31903163
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

HJ Park et al. (2019), Lycorine Attenuates Autophagy in Osteoclasts via an Axis of mROS/TRPML1/TFEB to Reduce LPS-Induced Bone Loss Oxid Med Cell Longev, 2019(0):8982147.
PMID: 31687088
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

J Lee et al. (2019), Mitofusin 2-Deficiency Suppresses Mycobacterium tuberculosis Survival in Macrophages Cells, 8(11).
PMID: 31671648
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

AM Mattson et al. (2019), Deficiency in the phosphatase PHLPP1 suppresses osteoclast-mediated bone resorption and enhances bone formation in mice J. Biol. Chem., 0(0).
PMID: 31189651
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

J Gilmour et al. (2019), Robust hematopoietic specification requires the ubiquitous Sp1 and Sp3 transcription factors Epigenetics Chromatin, 12(1):33.
PMID: 31164147
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

ZQ Hu et al. (2019), Rab32 GTPase, as a direct target of miR-30b/c, controls the intracellular survival of Burkholderia pseudomallei by regulating phagosome maturation PLoS Pathog., 15(6):e1007879.
PMID: 31199852
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

B Hu et al. (2019), Dehydrocostus lactone attenuates osteoclastogenesis and osteoclast-induced bone loss by modulating NF-?B signalling pathway J. Cell. Mol. Med., 0(0).
PMID: 31225720
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

CP Hans et al. (2019), Transcriptomics Analysis Reveals New Insights into the Roles of Notch1 Signaling on Macrophage Polarization Sci Rep, 9(1):7999.
PMID: 31142802
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

K Chen et al. (2019), Sfrp4 repression of the Ror2/Jnk cascade in osteoclasts protects cortical bone from excessive endosteal resorption Proc. Natl. Acad. Sci. U.S.A., 0(0).
PMID: 31239337
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

SS Welc et al. (2019), Targeting a therapeutic LIF transgene to muscle via the immune system ameliorates muscular dystrophy Nat Commun, 10(1):2788.
PMID: 31243277
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

S Marino et al. (2019), Paradoxical effects of JZL184, an inhibitor of monoacylglycerol lipase, on bone remodelling in healthy and cancer-bearing mice EBioMedicine, 44(0):452-466.
PMID: 31151929
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

S Lucas et al. (2018), Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss Nat Commun, 9(1):55.
PMID: 29302038
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

I Di Ceglie et al. (2018), Fc? receptor-mediated influx of S100A8/A9-producing neutrophils as inducer of bone erosion during antigen-induced arthritis Arthritis Res. Ther., 20(1):80.
PMID: 29720243
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

H Quan et al. (2018), LncRNA-AK131850 Sponges MiR-93-5p in Newborn and Mature Osteoclasts to Enhance the Secretion of Vascular Endothelial Growth Factor a Promoting Vasculogenesis of Endothelial Progenitor Cells Cell. Physiol. Biochem., 46(1):401-417.
PMID: 29590659
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

R Berndt et al. (2018), Allogeneic transplantation of programmable cells of monocytic origin (PCMO) improves angiogenesis and tissue recovery in critical limb ischemia (CLI): a translational approach Stem Cell Res Ther, 9(1):117.
PMID: 29703251
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

JE Draper et al. (2018), A novel prospective isolation of murine fetal liver progenitors to study in utero hematopoietic defects PLoS Genet., 14(1):e1007127.
PMID: 29300724
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

S Kinsella et al. (2018), Increased A20-E3 ubiquitin ligase interactions in bid-deficient glia attenuate TLR3- and TLR4-induced inflammation J Neuroinflammation, 15(1):130.
PMID: 29720226
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

HJ Koh et al. (2018), CD82 hypomethylation is essential for tuberculosis pathogenesis via regulation of RUNX1-Rab5/22 Exp. Mol. Med., 50(5):62.
PMID: 29760437
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

D Quach et al. (2018), Microbiota Reconstitution Does Not Cause Bone Loss in Germ-Free Mice mSphere, 3(1).
PMID: 29299532
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

G Jin et al. (2018), Neogambogic Acid Suppresses Receptor Activator of Nuclear Factor ?B Ligand (RANKL)-Induced Osteoclastogenesis by Inhibiting the JNK and NF-?B Pathways in Mouse Bone Marrow-Derived Monocyte/Macrophages Med. Sci. Monit., 24(0):2569-2577.
PMID: 29698379
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

SM Jung et al. (2018), Fraxinellone Attenuates Rheumatoid Inflammation in Mice Int J Mol Sci, 19(3).
PMID: 29533969
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

M Langer et al. (2018), Neither Lys- and DAP-type peptidoglycans stimulate mouse or human innate immune cells via Toll-like receptor 2 PLoS ONE, 13(2):e0193207.
PMID: 29474374
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

H Cui et al. (2018), IFN Regulatory Factor 2 Inhibits Expression of Glycolytic Genes and Lipopolysaccharide-Induced Proinflammatory Responses in Macrophages J. Immunol., 0(0).
PMID: 29563175
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

C Sun et al. (2018), RGC32 Promotes Bleomycin-Induced Systemic Sclerosis in a Murine Disease Model by Modulating Classically Activated Macrophage Function J. Immunol., 0(0).
PMID: 29507108
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Y Hu et al. (2018), SLC15A2 and SLC15A4 Mediate the Transport of Bacterially Derived Di/Tripeptides To Enhance the Nucleotide-Binding Oligomerization Domain-Dependent Immune Response in Mouse Bone Marrow-Derived Macrophages J. Immunol., 0(0).
PMID: 29784761
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Z Li et al. (2018), MTOR Suppresses Environmental Particle-Induced Inflammatory Response in Macrophages J. Immunol., 0(0).
PMID: 29563176
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

SB Jung et al. (2018), Reduced oxidative capacity in macrophages results in systemic insulin resistance Nat Commun, 9(1):1551.
PMID: 29674655
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

S Srivastava et al. (2018), Inflammatory response of microglia to prions is controlled by sialylation of PrPSc Sci Rep, 8(1):11326.
PMID: 30054538
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

MGA Broeren et al. (2018), Treatment of collagenase-induced osteoarthritis with a viral vector encoding TSG-6 results in ectopic bone formation PeerJ, 6(0):e4771.
PMID: 29868252
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

BF Westendorp et al. (2018), Indian Hedgehog Suppresses a Stromal Cell-Driven Intestinal Immune Response Cell Mol Gastroenterol Hepatol, 5(1):67-82.e1.
PMID: 29276753
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

MA Ferko et al. (2018), Effects of metal ions on caspase-1 activation and interleukin-1? release in murine bone marrow-derived macrophages PLoS ONE, 13(8):e0199936.
PMID: 30138321
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

G Melagraki et al. (2018), In Silico Discovery of Plant-Origin Natural Product Inhibitors of Tumor Necrosis Factor (TNF) and Receptor Activator of NF-?B Ligand (RANKL) Front Pharmacol, 9(0):800.
PMID: 30090063
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

G Locatelli et al. (2018), Mononuclear phagocytes locally specify and adapt their phenotype in a multiple sclerosis model Nat. Neurosci., 21(9):1196-1208.
PMID: 30127427
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

JM Ubellacker et al. (2018), Modulating bone marrow hematopoietic lineage potential to prevent bone metastasis in breast cancer Cancer Res., 0(0).
PMID: 30065048
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Y Zur et al. (2018), A dual-specific macrophage colony-stimulating factor antagonist of c-FMS and ?v?3 integrin for osteoporosis therapy PLoS Biol., 16(8):e2002979.
PMID: 30142160
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Y Yin et al. (2018), Human umbilical cord-derived mesenchymal stem cells direct macrophage polarization to alleviate pancreatic islets dysfunction in type 2 diabetic mice Cell Death Dis, 9(7):760.
PMID: 29988034
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

C McCarthy et al. (2018), Statin as a novel pharmacotherapy of pulmonary alveolar proteinosis Nat Commun, 9(1):3127.
PMID: 30087322
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Y Ikebuchi et al. (2018), Coupling of bone resorption and formation by RANKL reverse signalling Nature, 0(0).
PMID: 30185903
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

X Yi et al. (2018), Silencing LAIR-1 in human THP-1 macrophage increases foam cell formation by modulating PPAR? and M2 polarization Cytokine, 111(0):194-205.
PMID: 30176557
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

X Su et al. (2018), Bone marrow mesenchymal stem cells tune the differentiation of myeloid-derived suppressor cells in bleomycin-induced lung injury Stem Cell Res Ther, 9(1):253.
PMID: 30257700
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

E Mobarak et al. (2018), Glucosylceramide modifies the LPS-induced inflammatory response in macrophages and the orientation of the LPS/TLR4 complex in silico Sci Rep, 8(1):13600.
PMID: 30206272
JK Kim et al. (2018), GABAergic signaling linked to autophagy enhances host protection against intracellular bacterial infections Nat Commun, 9(1):4184.
PMID: 30305619
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

J Meng et al. (2018), Stevioside Prevents Wear Particle-Induced Osteolysis by Inhibiting Osteoclastogenesis and Inflammatory Response via the Suppression of TAK1 Activation Front Pharmacol, 9(0):1053.
PMID: 30319406
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

X Xiang et al. (2018), The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans Mol Neurodegener, 13(1):49.
PMID: 30185230
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

A Rubio-Arai et al. (2018), Anti-TLR2 antibody triggers oxidative phosphorylation in microglia and increases phagocytosis of ?-amyloid J Neuroinflammation, 15(1):247.
PMID: 30170611
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

GT Ma et al. (2018), Artemisinin-Daumone Hybrid Inhibits Cancer Cell-Mediated Osteolysis by Targeting Cancer Cells and Osteoclasts Cell. Physiol. Biochem., 49(4):1460-1475.
PMID: 30205376
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

M Das et al. (2018), Induction of Krï¿½ppel-like factor 2 reduces K/BxN serum-induced arthritis J. Cell. Mol. Med., 0(0).
PMID: 30506878
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

MB Uccellini et al. (2018), ISRE-Reporter Mouse Reveals High Basal and Induced Type I IFN Responses in Inflammatory Monocytes Cell Rep, 25(10):2784-2796.e3.
PMID: 30517866
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

K Subramania et al. (2018), Pneumolysin binds to the mannose receptor C type 1 (MRC-1) leading to anti-inflammatory responses and enhanced pneumococcal survival Nat Microbiol, 0(0).
PMID: 30420782
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

SJ Bae et al. (2018), Protective effects of a traditional herbal extract from Stellaria dichotoma var. lanceolata against Mycobacterium abscessus infections PLoS ONE, 13(11):e0207696.
PMID: 30452471
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

AN Billin et al. (2018), HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction-induced injury Skelet Muscle, 8(1):35.
PMID: 30424786
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

V Beneke et al. (2018), An immune cell spray (ICS) formulation allows for the delivery of functional monocyte/macrophages Sci Rep, 8(1):16281.
PMID: 30389997
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

KM Lee et al. (2018), Inhibition of STAT5A promotes osteogenesis by DLX5 regulation Cell Death Dis, 9(11):1136.
PMID: 30429452
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

MN Lee et al. (2018), Elevated extracellular calcium ions promote proliferation and migration of mesenchymal stem cells via increasing osteopontin expression Exp. Mol. Med., 50(11):142.
PMID: 30393382
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

J Zhou et al. (2018), Exosomes released from tumor-associated macrophages transfer miRNAs that induce a Treg/Th17 cell imbalance in epithelial ovarian cancer Cancer Immunol Res, 0(0).
PMID: 30396909
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Q Ye et al. (2018), Targeted disruption of adenosine kinase in myeloid monocyte cells increases osteoclastogenesis and bone resorption in mice Int. J. Mol. Med., 0(0).
PMID: 29344645
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

SA O'Sullivan et al. (2018), Sphingosine 1-phosphate receptors regulate TLR4-induced CXCL5 release from astrocytes and microglia J. Neurochem., 0(0).
PMID: 29377126
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Y Ito et al. (2018), Toll-Interacting Protein, Tollip, Inhibits IL-13-Mediated Pulmonary Eosinophilic Inflammation in Mice J Innate Immun, 0(0).
PMID: 29393212
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

E Yoshida et al. (2018), Hyperactivation of Nrf2 leads to hypoplasia of bone in vivo Genes Cells, 0(0).
PMID: 29542224
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

SM Oh et al. (2018), TNF-?-mediated ER stress causes elimination of Mycobacterium fortuitum reservoirs by macrophage apoptosis FASEB J., 0(0):fj201701407R.
PMID: 29481309
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

T Ishii et al. (2018), OC-STAMP promotes osteoclast fusion for pathogenic bone resorption in periodontitis via up-regulation of permissive fusogen CD9 FASEB J., 0(0):fj201701424R.
PMID: 29533736
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

D Gr?evi? et al. (2018), The Long Pentraxin 3 Plays a Role in Bone Turnover and Repair Front Immunol, 9(0):417.
PMID: 29556234
Species: Mouse
Sample Types: Whole Cells
Applications: Differentiation

A Mediero et al. (2018), Adenosine Areceptor (A2AR) stimulation modulates expression of semaphorins 4D and 3A, regulators of bone homeostasis FASEB J., 0(0):fj201700217R.
PMID: 29394106
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Y Zhang et al. (2018), PGC1? Organizes the Osteoclast Cytoskeleton by Mitochondrial Biogenesis and Activation J. Bone Miner. Res., 0(0).
PMID: 29521005
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

ZK Jia et al. (2018), Monomeric C-Reactive Protein Binds and Neutralizes Receptor Activator of NF-?B Ligand-Induced Osteoclast Differentiation Front Immunol, 9(0):234.
PMID: 29520264
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

M Datta et al. (2018), Histone Deacetylases 1 and 2 Regulate Microglia Function during Development, Homeostasis, and Neurodegeneration in a Context-Dependent Manner Immunity, 0(0).
PMID: 29548672
Species: Mouse
Sample Types: Whole Cells
Applications: Differentiation

A Das et al. (2018), High-Resolution Mapping and Dynamics of the Transcriptome, Transcription Factors, and Transcription Co-Factor Networks in Classically and Alternatively Activated Macrophages Front Immunol, 9(0):22.
PMID: 29403501
Species: Mouse
Sample Types: Whole Tissue
Applications: Cell Culture

D Song et al. (2018), Poria cocos polysaccharide attenuates RANKL-induced osteoclastogenesis by suppressing NFATc1 activity and phosphorylation of ERK and STAT3 Arch. Biochem. Biophys., 647(0):76-83.
PMID: 29678628
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

CEJ Waterborg et al. (2018), Protective Role of the MER Tyrosine Kinase via Efferocytosis in Rheumatoid Arthritis Models Front Immunol, 9(0):742.
PMID: 29706963
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

T Hara et al. (2018), Protease-Activated Receptor-2 Plays a Critical Role in Vascular Inflammation and Atherosclerosis in Apolipoprotein E-Deficient Mice Circulation, 0(0).
PMID: 29700120
Species: Mouse
Sample Types: Whole Cell
Applications: Cell Culture

M Zhang et al. (2018), Systemic administration of ?-glucan of 200ï¿½kDa modulates melanoma microenvironment and suppresses metastatic cancer Oncoimmunology, 7(2):e1387347.
PMID: 29308312
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

C Kajiwara et al. (2017), Metformin Mediates Protection against Legionella Pneumonia through Activation of AMPK and Mitochondrial Reactive Oxygen Species J. Immunol., 0(0).
PMID: 29246951
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

H Yang et al. (2017), Interleukin-13 reduces cardiac injury and prevents heart dysfunction in viral myocarditis via enhanced M2 macrophage polarization Oncotarget, 8(59):99495-99503.
PMID: 29245918
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

X Pei et al. (2017), The PSMP-CCR2 interactions trigger monocyte/macrophage-dependent colitis Sci Rep, 7(1):5107.
PMID: 28698550
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

MJ Strowitzki et al. (2017), Pharmacological HIF-inhibition attenuates postoperative adhesion formation Sci Rep, 7(1):13151.
PMID: 29030625
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

DC Nascimento et al. (2017), IL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population Nat Commun, 8(0):14919.
PMID: 28374774
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

OJ Park et al. (2017), Muramyl Dipeptide, a Shared Structural Motif of Peptidoglycans, Is a Novel Inducer of Bone Formation through Induction of Runx2 J. Bone Miner. Res, 0(0).
PMID: 28337794
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

S Gao et al. (2017), PEDF mediates pathological neovascularization by regulating macrophage recruitment and polarization in the mouse model of oxygen-induced retinopathy Sci Rep, 7(0):42846.
PMID: 28211523
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

H Huang et al. (2017), Preferred M2 Polarization by ASC-Based Hydrogel Accelerated Angiogenesis and Myogenesis in Volumetric Muscle Loss Rats Stem Cells Int, 2017(0):2896874.
PMID: 28694827
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

G Hanouna et al. (2017), Specific calpain inhibition protects kidney against inflammaging Sci Rep, 7(1):8016.
PMID: 28808241
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

F Zhou et al. (2017), Gastrodin inhibits osteoclastogenesis via down-regulating the NFATc1 signaling pathway and stimulates osseointegration in vitro Biochem. Biophys. Res. Commun, 0(0).
PMID: 28161640
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

J Ahn et al. (2017), STING-Dependent Signaling Underlies IL-10 Controlled Inflammatory Colitis Cell Rep, 21(13):3873-3884.
PMID: 29281834
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

F Strålberg et al. (2017), Inhibition of lipopolysaccharide-induced osteoclast formation and bone resorption in vitro and in vivo by cysteine proteinase inhibitors J. Leukoc. Biol, 0(0).
PMID: 28196851
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

HJ Koh et al. (2017), Toxoplasma gondii GRA7-Targeted ASC and PLD1 Promote Antibacterial Host Defense via PKCï¿½ PLoS Pathog, 13(1):e1006126.
PMID: 28125719
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

L Zhang et al. (2017), 25-hydroxycholesterol promotes RANKL-induced osteoclastogenesis through coordinating NFATc1 and Sp1 complex in the transcription of miR-139-5p Biochem. Biophys. Res. Commun, 0(0).
PMID: 28257846
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

CM Novince et al. (2017), Commensal Gut Microbiota Immunomodulatory Actions in Bone Marrow and Liver have Catabolic Effects on Skeletal Homeostasis in Health Sci Rep, 7(1):5747.
PMID: 28720797
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

J Liu et al. (2017), NF-?B activation is critical for bacterial lipoprotein tolerance-enhanced bactericidal activity in macrophages during microbial infection Sci Rep, 7(0):40418.
PMID: 28079153
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

HJ Ihn et al. (2017), OCLI-023, a Novel Pyrimidine Compound, Suppresses Osteoclastogenesis In Vitro and Alveolar Bone Resorption In Vivo PLoS ONE, 12(1):e0170159.
PMID: 28085946
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

L Parviainen et al. (2017), Glial cells are functionally impaired in juvenile neuronal ceroid lipofuscinosis and detrimental to neurons Acta Neuropathol Commun, 5(1):74.
PMID: 29041969
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

M Eger et al. (2017), Scaling of titanium implants entrains inflammation-induced osteolysis Sci Rep, 7(0):39612.
PMID: 28059080
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay

C Carmona-Fo et al. (2017), Metabolic origins of spatial organization in the tumor microenvironment Proc. Natl. Acad. Sci. U.S.A, 0(0).
PMID: 28246332
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

E Kindstedt et al. (2017), CCL11, a novel mediator of inflammatory bone resorption Sci Rep, 7(1):5334.
PMID: 28706221
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

LH He et al. (2017), TRPV1 deletion impaired fracture healing and inhibited osteoclast and osteoblast differentiation Sci Rep, 7(0):42385.
PMID: 28225019
KM Schneider et al. (2017), The influence of macrophage growth factors on Theiler's Murine Encephalomyelitis Virus (TMEV) infection and activation of macrophages Cytokine, 0(0).
PMID: 28800924
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

G Colaianni et al. (2017), Irisin prevents and restores bone loss and muscle atrophy in hind-limb suspended mice Sci Rep, 7(1):2811.
PMID: 28588307
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

JH Oh et al. (2017), Up-Regulation of RANK Expression via ERK1/2 by Insulin Contributes to the Enhancement of Osteoclast Differentiation Mol. Cells, 40(5):371-377.
PMID: 28535663
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

JW Lee et al. (2017), The HIV co-receptor CCR5 regulates osteoclast function Nat Commun, 8(1):2226.
PMID: 29263385
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

EM Grössinger et al. (2017), Ca2+-Dependent Regulation of NFATc1 via KCa3.1 in Inflammatory Osteoclastogenesis J. Immunol., 0(0).
PMID: 29246953
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

YS Kim et al. (2017), PPAR-? Activation Mediates Innate Host Defense through Induction of TFEB and Lipid Catabolism J. Immunol, 0(0).
PMID: 28275133
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

SB Mkaddem et al. (2017), Lyn and Fyn function as molecular switches that control immunoreceptors to direct homeostasis or inflammation Nat Commun, 8(1):246.
PMID: 28811476
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Y Feng et al. (2017), Extracellular MicroRNAs Induce Potent Innate Immune Responses via TLR7/MyD88-Dependent Mechanisms J. Immunol., 0(0).
PMID: 28768728
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

ST Chen et al. (2017), CLEC5A is a critical receptor in innate immunity against Listeria infection Nat Commun, 8(1):299.
PMID: 28824166
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

A Aki et al. (2017), Hypomorphic A20 expression confers susceptibility to psoriasis PLoS ONE, 12(6):e0180481.
PMID: 28658319
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

OC Olson et al. (2017), Tumor-Associated Macrophages Suppress the Cytotoxic Activity of Antimitotic Agents Cell Rep, 19(1):101-113.
PMID: 28380350
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

SW Choi et al. (2017), Barley Seedling Extracts Inhibit RANKL-Induced Differentiation, Fusion, and Maturation of Osteoclasts in the Early-to-Late Stages of Osteoclastogenesis Evid Based Complement Alternat Med, 2017(0):6072573.
PMID: 28567098
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

A Itoh-Nakad et al. (2017), A Bach2-Cebp Gene Regulatory Network for the Commitment of Multipotent Hematopoietic Progenitors Cell Rep, 18(10):2401-2414.
PMID: 28273455
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

SY Kim et al. (2017), ESRRA (estrogen related receptor, alpha) is a key coordinator of transcriptional and post-translational activation of autophagy to promote innate host defense Autophagy, 0(0):0.
PMID: 28841353
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

A Wang et al. (2017), Activity-independent targeting of mTOR to lysosomes in primary osteoclasts Sci Rep, 7(1):3005.
PMID: 28592812
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

BA Fensterhei et al. (2017), The Cytokine Response to Lipopolysaccharide Does Not Predict the Host Response to Infection J. Immunol, 0(0).
PMID: 28275139
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

HH Chen et al. (2017), Theranostic Nucleic Acid Binding Nanoprobe Exerts Anti-inflammatory and Cytoprotective Effects in Ischemic Injury Theranostics, 7(4):814-825.
PMID: 28382156
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

V Kram et al. (2017), Small leucine rich proteoglycans, a novel link to osteoclastogenesis Sci Rep, 7(1):12627.
PMID: 28974711
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

JY Ao et al. (2017), Colony-stimulating factor 1 receptor blockade inhibits tumor growth by altering the polarization of tumor-associated macrophages in hepatocellular carcinoma Mol. Cancer Ther., 0(0).
PMID: 28572167
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

E Kim et al. (2017), Inositol polyphosphate multikinase promotes Toll-like receptor-induced inflammation by stabilizing TRAF6 Sci Adv, 3(4):e1602296.
PMID: 28439546
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Y Yin et al. (2017), MiR-30a attenuates osteoclastogenesis via targeting DC-STAMP-c-Fos-NFATc1 signaling Am J Transl Res, 9(12):5743-5753.
PMID: 29312525
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

McCarthy R et al. (2016), Characterization of a novel adult murine immortalized microglial cell line and its activation by amyloid-beta. J Neuroinflammation, 13(1):21.
PMID: 26819091
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Hernandez A et al. (2016), The role of MyD88- and TRIF-dependent signaling in monophosphoryl lipid A-induced expansion and recruitment of innate immunocytes. J Leukoc Biol, 100(6):1311-1322.
PMID: 27354411
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

J Fu et al. (2016), Multiple myeloma-derived MMP-13 mediates osteoclast fusogenesis and osteolytic disease J Clin Invest, 0(0).
PMID: 27043283
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

(2016), Negative regulation of bacterial killing and inflammation by two novel CD16 ligands Eur J Immunol, 0(0).
PMID: 27226142
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Erivan S Ramos-Juni (2016), Adipokine Chemerin Bridges Metabolic Dyslipidemia and Alveolar Bone Loss in Mice J. Bone Miner. Res, 0(0).
PMID: 28029186
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

(2016), Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status Circ Res, 0(0).
PMID: 27418629
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

(2016), Cytoskeleton-centric protein transportation by exosomes transforms tumor-favorable macrophages Oncotarget, 0(0).
PMID: 27602764
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

(2016), Inhibition of cathepsin X reduces the strength of microglial-mediated neuroinflammation Neuropharmacology, 114(0):88-100.
PMID: 27889490
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Pesce Viglietti A et al. (2016), Brucella abortus Invasion of Osteocytes Modulates Connexin 43 and Integrin Expression and Induces Osteoclastogenesis via Receptor Activator of NF-kappaB Ligand and Tumor Necrosis Factor Alpha Secretion. Infect Immun, 84(1):11-20.
PMID: 26459511
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Young-Ran Yoon (2016), Docosahexaenoic acid signaling attenuates the proliferation and differentiation of bone marrow-derived osteoclast precursors and promotes apoptosis in mature osteoclasts Cell. Signal., 29(0):226-232.
PMID: 27836739
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

(2016), Spatiotemporal expression of endogenous TLR4 ligands leads to inflammation and bone erosion in mouse collagen-induced arthritis Eur J Immunol, 0(0).
PMID: 27510283
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

(2016), Mycobacterium abscessus ESX-3 plays an important role in host inflammatory and pathological responses during infection Microbes Infect, 0(0).
PMID: 27637463
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

(2016), TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance EMBO Mol Med, 0(0).
PMID: 27402340
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

L Bossaller et al. (2016), TLR9 Deficiency Leads to Accelerated Renal Disease and Myeloid Lineage Abnormalities in Pristane-Induced Murine Lupus J. Immunol., 197(4):1044-53.
PMID: 27354219
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

(2016), Mycobacterium avium MAV2054 protein induces macrophage apoptosis by targeting mitochondria and reduces intracellular bacterial growth Sci Rep, 6(0):37804.
PMID: 27901051
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Dechun Geng (2016), Theaflavin-3,3'-digallate represses osteoclastogenesis and prevents wear debris-induced osteolysis via suppression of ERK pathway Acta Biomater, 0(0).
PMID: 27838465
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Sarit Batsir (2016), Dynamics of the sealing zone in cultured osteoclasts Cytoskeleton (Hoboken), 0(0).
PMID: 27997747
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

(2016), MicroRNAs: Potential Biomarkers and Therapeutic Targets for Alveolar Bone Loss in Periodontal Disease Int J Mol Sci, 17(8).
PMID: 27529224
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Khor E et al. (2016), Prader-Willi Critical Region, a Non-Translated, Imprinted Central Regulator of Bone Mass: Possible Role in Skeletal Abnormalities in Prader-Willi Syndrome. PLoS ONE, 11(1):e0148155.
PMID: 26824232
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

(2016), Defect density in multiwalled carbon nanotubes influences ovalbumin adsorption and promotes macrophage activation and CD4(+) T-cell proliferation Int J Nanomedicine, 11(0):4357-71.
PMID: 27621627
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

(2016), The Role of Prostate Apoptosis Response-4 (Par-4) in Mycobacterium tuberculosis Infected Macrophages Sci Rep, 6(0):32079.
PMID: 27552917
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

(2016), Treatment with cestode parasite antigens recruits CCR2+ myeloid cells, the adoptive transfer of which ameliorates colitis Infect Immun, 0(0).
PMID: 27672083
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Sabrina Ceeraz (2016), VISTA deficiency accelerates the development of fatal murine lupus nephritis Arthritis rheumatology (Hoboken, N.J.), 2016;0(0).
PMID: 27992697
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

(2016), The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity Cell, 0(0).
PMID: 27523608
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

L Ren et al. (2016), Analysis of the Effects of the Bruton's tyrosine kinase (Btk) Inhibitor Ibrutinib on Monocyte Fc? Receptor (Fc?R) Function J. Biol. Chem, 291(6):3043-52.
PMID: 26627823
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

(2016), Macrophages and cardiac fibroblasts are the main producers of eotaxins and regulate eosinophil trafficking to the heart Eur J Immunol, 0(0).
PMID: 27621211
Species: Mouse
Sample Types: Whole Cells

Janko Kos (2016), Inhibition of cathepsin X reduces the strength of microglial-mediated neuroinflammation Neuropharmacology, 114(0):88-100.
PMID: 27889490
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

(2016), Roles of endoplasmic reticulum stress-mediated apoptosis in M1-polarized macrophages during mycobacterial infections Sci Rep, 6(0):37211.
PMID: 27845414
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Jean-Philippe Pradère et al. (2016), Negative regulation of NF-?B p65 activity by serine 536 phosphorylation. Science Signaling, 0(0):1937-9145.
PMID: 27555662
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Kim K et al. (2015), 15-deoxy-delta12,14-prostaglandin j2 inhibits osteolytic breast cancer bone metastasis and estrogen deficiency-induced bone loss. PLoS ONE, 10(4):e0122764.
PMID: 25859665
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Li B et al. (2015), Targeted 25-hydroxyvitamin D3 1alpha-hydroxylase adoptive gene therapy ameliorates dss-induced colitis without causing hypercalcemia in mice. Mol Ther, 23(2):339-51.
PMID: 25327179
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Guo J et al. (2015), Iron Chelation Inhibits Osteoclastic Differentiation In Vitro and in Tg2576 Mouse Model of Alzheimer's Disease. PLoS ONE, 10(11):e0139395.
PMID: 26575486
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Youm Y et al. (2015), The ketone metabolite beta-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. Nat Med, 21(3):263-9.
PMID: 25686106
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Sophocleous A et al. (2015), Bone Cell-autonomous Contribution of Type 2 Cannabinoid Receptor to Breast Cancer-induced Osteolysis. J Biol Chem, 290(36):22049-60.
PMID: 26195631
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Yang C et al. (2015), Small heterodimer partner interacts with NLRP3 and negatively regulates activation of the NLRP3 inflammasome. Nat Commun, 6(0):6115.
PMID: 25655831
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Herbert B et al. (2015), Sexual Dimorphism in MAPK-Activated Protein Kinase-2 (MK2) Regulation of RANKL-Induced Osteoclastogenesis in Osteoclast Progenitor Subpopulations. PLoS ONE, 10(5):e0125387.
PMID: 25946081
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Wang X et al. (2015), Sim1 inhibits bone formation by enhancing the sympathetic tone in male mice. Endocrinology, 156(4):1408-15.
PMID: 25607894
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Greenblatt M et al. (2015), CHMP5 controls bone turnover rates by dampening NF-kappaB activity in osteoclasts. J Exp Med, 212(8):1283-301.
PMID: 26195726
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Wertz I et al. (2015), Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Nature, 528(7582):370-5.
PMID: 26649818
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Ozanne J et al. (2015), The clinically approved drugs dasatinib and bosutinib induce anti-inflammatory macrophages by inhibiting the salt-inducible kinases. Biochem J, 465(2):271-9.
PMID: 25351958
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Xu X et al. (2015), GPCR-mediated PLCbetagamma/PKCbeta/PKD signaling pathway regulates the cofilin phosphatase slingshot 2 in neutrophil chemotaxis. Mol Biol Cell, 26(5):874-86.
PMID: 25568344
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Mediero A et al. (2015), Netrin-1 is a critical autocrine/paracrine factor for osteoclast differentiation. J Bone Miner Res, 30(5):837-54.
PMID: 25483983
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Jha A et al. (2015), Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization. Immunity, 42(3):419-30.
PMID: 25786174
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Kim J et al. (2015), MicroRNA-125a Inhibits Autophagy Activation and Antimicrobial Responses during Mycobacterial Infection. J Immunol, 194(11):5355-65.
PMID: 25917095
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Kassem A et al. (2015), Porphyromonas gingivalis Stimulates Bone Resorption by Enhancing RANKL (Receptor Activator of NF-kappaB Ligand) through Activation of Toll-like Receptor 2 in Osteoblasts. J Biol Chem, 290(33):20147-58.
PMID: 26085099
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Li et al. (2015), MicroRNA-188 regulates age-related switch between osteoblast and adipocyte differentiation. J Clin Invest, 125(4):1509-22.
PMID: 25751060
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Oberoi R et al. (2015), Lipocalin (LCN) 2 Mediates Pro-Atherosclerotic Processes and Is Elevated in Patients with Coronary Artery Disease. PLoS ONE, 10(9):e0137924.
PMID: 26367277
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Behler F et al. (2015), Macrophage-inducible C-type lectin Mincle-expressing dendritic cells contribute to control of splenic Mycobacterium bovis BCG infection in mice. Infect Immun, 83(1):184-96.
PMID: 25332121
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Liu K et al. (2015), Impaired macrophage autophagy increases the immune response in obese mice by promoting proinflammatory macrophage polarization. Autophagy, 11(2):271-84.
PMID: 25650776
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Ihn H et al. (2015), Inhibitory Effects of KP-A159, a Thiazolopyridine Derivative, on Osteoclast Differentiation, Function, and Inflammatory Bone Loss via Suppression of RANKL-Induced MAP Kinase Signaling Pathway. PLoS ONE, 10(11):e0142201.
PMID: 26536233
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Zhao Z et al. (2015), TNF Induction of NF-kappaB RelB Enhances RANKL-Induced Osteoclastogenesis by Promoting Inflammatory Macrophage Differentiation but also Limits It through Suppression of NFATc1 Expression. PLoS ONE, 10(8):e0135728.
PMID: 26287732
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Wang F et al. (2015), Mouse Resistin (mRetn): cloning, expression and purification in Escherichia coli and the potential regulative effects on murine bone marrow hematopoiesis. BMC Biotechnol, 15(0):105.
PMID: 26572487
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Ucer S et al. (2015), The Effects of Androgens on Murine Cortical Bone Do Not Require AR or ERalpha Signaling in Osteoblasts and Osteoclasts. J Bone Miner Res, 30(7):1138-49.
PMID: 25704845
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Martin I et al. (2015), Fasciola hepatica fatty acid binding protein inhibits TLR4 activation and suppresses the inflammatory cytokines induced by lipopolysaccharide in vitro and in vivo. J Immunol, 194(8):3924-36.
PMID: 25780044
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Fowler T et al. (2015), Activin A inhibits RANKL-mediated osteoclast formation, movement and function in murine bone marrow macrophage cultures. J Cell Sci, 128(4):683-94.
PMID: 25609708
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Shimizu K et al. (2015), IL-1 receptor type 2 suppresses collagen-induced arthritis by inhibiting IL-1 signal on macrophages. J Immunol, 194(7):3156-68.
PMID: 25725107
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Zhang Y et al. (2015), Anabolic bone formation via a site-specific bone-targeting delivery system by interfering with semaphorin 4D expression. J Bone Miner Res, 30(2):286-96.
PMID: 25088728
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Negishi-Koga T et al. (2015), Immune complexes regulate bone metabolism through FcRgamma signalling. Nat Commun, 6(0):6637.
PMID: 25824719
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Matsushita M et al. (2015), A novel phthalimide derivative, TC11, has preclinical effects on high-risk myeloma cells and osteoclasts. PLoS ONE, 10(1):e0116135.
PMID: 25617756
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Maeda A et al. (2015), WNT1-induced Secreted Protein-1 (WISP1), a Novel Regulator of Bone Turnover and Wnt Signaling. J Biol Chem, 290(22):14004-18.
PMID: 25864198
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Alshbool F et al. (2015), Differential expression of claudin family members during osteoblast and osteoclast differentiation: Cldn-1 is a novel positive regulator of osteoblastogenesis. PLoS ONE, 9(12):e114357.
PMID: 25479235
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Amano et al. (2015), ERK5 Activation Is Essential for Osteoclast Differentiation. PLoS ONE, 10(4):e0125054.
PMID: 25885811
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Yu H et al. (2015), FTY720 inhibited proinflammatory cytokine release and osteoclastogenesis induced by Aggregatibacter actinomycetemcomitans. Lipids Health Dis, 14(0):66.
PMID: 26138336
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Antony C et al. (2015), Regulation of L-type Voltage Gated Calcium Channel CACNA1S in Macrophages upon Mycobacterium tuberculosis Infection. PLoS ONE, 10(4):e0124263.
PMID: 25915405
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Tan Z et al. (2015), Pyruvate dehydrogenase kinase 1 participates in macrophage polarization via regulating glucose metabolism. J Immunol, 194(12):6082-9.
PMID: 25964487
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Abe T et al. (2014), Regulation of osteoclast homeostasis and inflammatory bone loss by MFG-E8. J Immunol, 193(3):1383-91.
PMID: 24958900
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

David M et al. (2014), Lysophosphatidic acid receptor type 1 (LPA1) plays a functional role in osteoclast differentiation and bone resorption activity. J Biol Chem, 289(10):6551-64.
PMID: 24429286
Tang et al. (2014), RasGRP3 limits Toll-like receptor-triggered inflammatory response in macrophages by activating Rap1 small GTPase. Nat Commun, 5(0):4657.
PMID: 25118589
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Gwyer Findlay et al. (2014), OX40L blockade is therapeutic in arthritis, despite promoting osteoclastogenesis. Proc Natl Acad Sci U S A, 111(6):2289-94.
PMID: 24469824
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Teramachi J et al. (2014), Increased IL-6 expression in osteoclasts is necessary but not sufficient for the development of Paget's disease of bone. J Bone Miner Res, 29(6):1456-65.
PMID: 24339057
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Krzeszinski J et al. (2014), miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2. Nature, 512(7515):431-5.
PMID: 25043055
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Zhao T et al. (2014), Myeloid-derived suppressor cells are involved in lysosomal acid lipase deficiency-induced endothelial cell dysfunctions. J Immunol, 193(4):1942-53.
PMID: 25000979
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Hayashida C et al. (2014), Osteocytes produce interferon-beta as a negative regulator of osteoclastogenesis. J Biol Chem, 289(16):11545-55.
PMID: 24610813
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Al Faraj et al. (2014), Preferential macrophage recruitment and polarization in LPS-induced animal model for COPD: noninvasive tracking using MRI. PLoS ONE, 9(3):e90829.
PMID: 24598763
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Fernando M et al. (2014), The pro-inflammatory cytokine, interleukin-6, enhances the polarization of alternatively activated macrophages. PLoS ONE, 9(4):e94188.
PMID: 24736635
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Ke K et al. (2014), Reactive oxygen species induce the association of SHP-1 with c-Src and the oxidation of both to enhance osteoclast survival. Am J Physiol Endocrinol Metab, 307(1):E61-70.
PMID: 24824657
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Inoue K et al. (2014), Identification of novel transcription factors in osteoclast differentiation using genome-wide analysis of open chromatin determined by DNase-seq. J Bone Miner Res, 29(8):1823-32.
PMID: 24677342
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

An J et al. (2014), Changes of microRNA profile and microRNA-mRNA regulatory network in bones of ovariectomized mice. J Bone Miner Res, 29(3):644-56.
PMID: 23929739
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Nacionales D et al. (2014), Aged mice are unable to mount an effective myeloid response to sepsis. J Immunol, 192(2):612-22.
PMID: 24337739
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Xie N et al. (2014), miR-27a regulates inflammatory response of macrophages by targeting IL-10. J Immunol, 193(1):327-34.
PMID: 24835395
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Gilmour J et al. (2014), A crucial role for the ubiquitously expressed transcription factor Sp1 at early stages of hematopoietic specification. Development, 141(12):2391-401.
PMID: 24850855
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Karpurapu M et al. (2014), Kruppel like factor 4 promoter undergoes active demethylation during monocyte/macrophage differentiation. PLoS ONE, 9(4):e93362.
PMID: 24695324
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Jeganathan S et al. (2014), Modulation of osteoclastogenesis with macrophage M1- and M2-inducing stimuli. PLoS ONE, 9(8):e104498.
PMID: 25101660
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Chaturvedi et al. (2014), Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment. Proc Natl Acad Sci U S A, 111(20):E2120-9.
PMID: 24799675
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Wu L et al. (2014), Cardiac fibroblasts mediate IL-17A-driven inflammatory dilated cardiomyopathy. J Exp Med, 211(7):1449-64.
PMID: 24935258
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Komatsu N et al. (2014), Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis. Nat Med, 20(1):62-8.
PMID: 24362934
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Mercken E et al. (2014), SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass. Aging Cell, 13(5):787-96.
PMID: 24931715
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Guo H et al. (2014), Lipocalin 2 is a regulator of macrophage polarization and NF-kappaB/STAT3 pathway activation. Mol Endocrinol, 28(10):1616-28.
PMID: 25127375
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Xiu Y et al. (2014), Chloroquine reduces osteoclastogenesis in murine osteoporosis by preventing TRAF3 degradation. J Clin Invest, 124(1):297-310.
PMID: 24316970
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Ohba T et al. (2014), Bisphosphonates inhibit osteosarcoma-mediated osteolysis via attenuation of tumor expression of MCP-1 and RANKL. J Bone Miner Res, 29(6):1431-45.
PMID: 24443409
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Zhao C et al. (2014), Cellular stress amplifies TLR3/4-induced CXCL1/2 gene transcription in mononuclear phagocytes via RIPK1. J Immunol, 193(2):879-88.
PMID: 24920846
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Jego G et al. (2014), Dual regulation of SPI1/PU.1 transcription factor by heat shock factor 1 (HSF1) during macrophage differentiation of monocytes. Leukemia, 28(8):1676-86.
PMID: 24504023
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Hsu W et al. (2014), C5L2 is required for C5a-triggered receptor internalization and ERK signaling. Cell Signal, 26(7):1409-19.
PMID: 24631530
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Zhang J et al. (2014), An unexpected twist to the activation of IKKbeta: TAK1 primes IKKbeta for activation by autophosphorylation. Biochem J, 461(3):531-7.
PMID: 24911653
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Bartell et al. (2014), FoxO proteins restrain osteoclastogenesis and bone resorption by attenuating H2O2 accumulation. Nat Commun, 5(0):3773.
PMID: 24781012
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Sharma et al. (2014), Caspase-2 maintains bone homeostasis by inducing apoptosis of oxidatively-damaged osteoclasts. PLoS ONE, 9(4):e93696.
PMID: 24691516
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Purdue et al. (2014), Comprehensive profiling analysis of actively resorbing osteoclasts identifies critical signaling pathways regulated by bone substrate. Sci Rep, 4(0):7595.
PMID: 25534583
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Noubade et al. (2014), NRROS negatively regulates reactive oxygen species during host defence and autoimmunity. Nature, 509(7499):235-9.
PMID: 24739962
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Yao C et al. (2014), The transcription factor T-box 3 regulates colony-stimulating factor 1-dependent Jun dimerization protein 2 expression and plays an important role in osteoclastogenesis. J Biol Chem, 289(10):6775-90.
PMID: 24394418
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Yang E et al. (2014), EGCG attenuates autoimmune arthritis by inhibition of STAT3 and HIF-1alpha with Th17/Treg control. PLoS ONE, 9(2):e86062.
PMID: 24558360
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Hamada et al. (2014), MafB promotes atherosclerosis by inhibiting foam-cell apoptosis. Nat Commun, 5(0):3147.
PMID: 24445679
Ohm I et al. (2014), Toll-like receptor 9 mediated responses in cardiac fibroblasts. PLoS ONE, 9(8):e104398.
PMID: 25126740
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Biosse Duplan et al. (2014), Microtubule dynamic instability controls podosome patterning in osteoclasts through EB1, cortactin, and Src. Mol Cell Biol, 34(1):16-29.
PMID: 24144981
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Yeon J et al. (2014), Anti-osteoclastogenic activity of praeruptorin A via inhibition of p38/Akt-c-Fos-NFATc1 signaling and PLCgamma-independent Ca2+ oscillation. PLoS ONE, 9(2):e88974.
PMID: 24586466
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Kang et al. (2014), A macrophage-specific synthetic promoter for therapeutic application of adiponectin. Gene Ther, 21(4):353-62.
PMID: 24500526
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

Hirose J et al. (2014), Bone resorption is regulated by cell-autonomous negative feedback loop of Stat5-Dusp axis in the osteoclast. J Exp Med, 211(1):153-63.
PMID: 24367002
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Sun Q et al. (2014), TBK1 mediates critical effects of measles virus nucleocapsid protein (MVNP) on pagetic osteoclast formation. J Bone Miner Res, 29(1):90-102.
PMID: 23794264
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

McMichael B et al. (2014), The RhoGAP activity of myosin IXB is critical for osteoclast podosome patterning, motility, and resorptive capacity. PLoS ONE, 9(1):e87402.
PMID: 24466350
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Isaac et al. (2014), DLX3 regulates bone mass by targeting genes supporting osteoblast differentiation and mineral homeostasis in vivo. Cell Death Differ, 21(9):1365-76.
PMID: 24948010
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Mukherjee et al. (2014), Distinct actions of akt1 on skeletal architecture and function. PLoS ONE, 9(3):e93040.
PMID: 24663486
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Wu C et al. (2014), IFN-gamma primes macrophage activation by increasing phosphatase and tensin homolog via downregulation of miR-3473b. J Immunol, 193(6):3036-44.
PMID: 25092892
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Chang Y et al. (2014), A novel TLR2-triggered signalling crosstalk synergistically intensifies TNF-mediated IL-6 induction. J Cell Mol Med, 18(7):1344-57.
PMID: 24758719
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Tatano Y et al. (2014), Unique macrophages different from M1/M2 macrophages inhibit T cell mitogenesis while upregulating Th17 polarization. Sci Rep, 4(0):4146.
PMID: 24553452
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Hunter et al. (2014), Heparanase promotes lymphangiogenesis and tumor invasion in pancreatic neuroendocrine tumors. Oncogene, 33(14):1799-808.
PMID: 23644656
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Zhong et al. (2014), T-cell costimulation protects obesity-induced adipose inflammation and insulin resistance. Diabetes, 63(4):1289-302.
PMID: 24222350
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Tiwari et al. (2014), A nonapoptotic role for CASP2/caspase 2: modulation of autophagy. Autophagy, 10(6):1054-70.
PMID: 24879153
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Zhang H et al. (2014), NOTCH inhibits osteoblast formation in inflammatory arthritis via noncanonical NF-kappaB. J Clin Invest, 124(7):3200-14.
PMID: 24892805
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Stalvey M et al. (2013), Osteoblast CFTR inactivation reduces differentiation and osteoprotegerin expression in a mouse model of cystic fibrosis-related bone disease. PLoS ONE, 8(11):e80098.
PMID: 24236172
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Jacome-Galarza C et al. (2013), Identification, characterization, and isolation of a common progenitor for osteoclasts, macrophages, and dendritic cells from murine bone marrow and periphery. J Bone Miner Res, 28(5):1203-13.
PMID: 23165930
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Ke K et al. (2013), Overexpression of developmentally regulated GTP-binding protein-2 increases bone loss. Am J Physiol Endocrinol Metab, 304(7):E703-10.
PMID: 23360825
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Xia W et al. (2013), Vps35 loss promotes hyperresorptive osteoclastogenesis and osteoporosis via sustained RANKL signaling. J Cell Biol, 200(6):821-37.
PMID: 23509071
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Xia W et al. (2013), Swedish mutant APP suppresses osteoblast differentiation and causes osteoporotic deficit, which are ameliorated by N-acetyl-L-cysteine. J Bone Miner Res, 28(10):2122-35.
PMID: 23649480
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Elcombe S et al. (2013), Dectin-1 regulates IL-10 production via a MSK1/2 and CREB dependent pathway and promotes the induction of regulatory macrophage markers. PLoS ONE, 8(3):e60086.
PMID: 23533666
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Bostrom E et al. (2013), The newly discovered cytokine IL-34 is expressed in gingival fibroblasts, shows enhanced expression by pro-inflammatory cytokines, and stimulates osteoclast differentiation. PLoS ONE, 8(12):e81665.
PMID: 24339952
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Kim H et al. (2013), Liver X receptor activation inhibits osteoclastogenesis by suppressing NF-kappaB activity and c-Fos induction and prevents inflammatory bone loss in mice. J Leukoc Biol, 94(1):99-107.
PMID: 23657115
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Muruganandan S et al. (2013), Chemerin neutralization blocks hematopoietic stem cell osteoclastogenesis. Stem Cells, 31(10):2172-82.
PMID: 23766088
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Shah P et al. (2013), Toll-like receptor 2 ligands regulate monocyte Fcgamma receptor expression and function. J Biol Chem, 288(17):12345-52.
PMID: 23504312
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Yang Z et al. (2013), Macrophages as IL-25/IL-33-responsive cells play an important role in the induction of type 2 immunity. , 0(0).
PMID: 23536877
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Yamamizu K et al. (2013), Identification of transcription factors for lineage-specific ESC differentiation. Stem Cell Reports, 1(6):545-59.
PMID: 24371809
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Kim J et al. (2013), Differential immune responses to Segniliparus rotundus and Segniliparus rugosus infection and analysis of their comparative virulence profiles. PLoS ONE, 8(3):e59646.
PMID: 23555735
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Braun T et al. (2013), Mitogen-activated protein kinase 2 regulates physiological and pathological bone turnover. J Bone Miner Res, 28(4):936-47.
PMID: 23169443
Zou W et al. (2013), Talin1 and Rap1 are critical for osteoclast function. Mol Cell Biol, 33(4):830-44.
PMID: 23230271
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Sandig H et al. (2013), IL-33 causes selective mast cell tolerance to bacterial cell wall products by inducing IRAK1 degradation. Eur J Immunol, 43(4):979-88.
PMID: 23404570
Species: Feline
Sample Types: Whole Cells
Applications: Bioassay

(2013), Cloning and expression of feline colony stimulating factor receptor (CSF-1R) and analysis of the species specificity of stimulation by colony stimulating factor-1 (CSF-1) and interleukin-34 (IL-34). Cytokine, 61(2):630-8.
PMID: 23260168
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Pau E et al. (2013), Identification of a lupus-susceptibility locus leading to impaired clearance of apoptotic debris on New Zealand Black chromosome 13. Genes Immun, 14(3):154-61.
PMID: 23328841
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Uchiyama R et al. (2013), Fas-mediated inflammatory response in Listeria monocytogenes infection. J Immunol, 190(8):4245-54.
PMID: 23509366
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Ma et al. (2013), RNA interference-mediated silencing of Atp6i prevents both periapical bone erosion and inflammation in the mouse model of endodontic disease. Infect Immun, 81(4):1021-30.
PMID: 23166162
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Choi J et al. (2013), Caffeine enhances osteoclast differentiation and maturation through p38 MAP kinase/Mitf and DC-STAMP/CtsK and TRAP pathway. Cell Signal, 25(5):1222-7.
PMID: 23434822
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

Lee S et al. (2013), Acteoside suppresses RANKL-mediated osteoclastogenesis by inhibiting c-Fos induction and NF-kappaB pathway and attenuating ROS production. PLoS ONE, 8(12):e80873.
PMID: 24324641
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

Song K et al. (2013), Lenalidomide inhibits lymphangiogenesis in preclinical models of mantle cell lymphoma. Cancer Res, 73(24):7254-64.
PMID: 24158094
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

(2012), Regulation of innate CD8+ T-cell activation mediated by cytokines. Proc Natl Acad Sci U S A, 109(25):9971-6.
PMID: 22665806
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Zhao E et al. (2012), Regulatory T cells in the bone marrow microenvironment in patients with prostate cancer. Oncoimmunology, 1(2):152-161.
PMID: 22720236
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Hayashi M et al. (2012), Osteoprotection by semaphorin 3A. Nature, 485(7396):69-74.
PMID: 22522930
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Barin JG et al. (2012), Macrophages participate in IL-17-mediated inflammation. Eur. J. Immunol., 42(3):726-36.
PMID: 22161142
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Hassan F et al. (2012), Role of c-Jun N-terminal protein kinase 1/2 (JNK1/2) in macrophage-mediated MMP-9 production in response to Moraxella catarrhalis lipooligosaccharide (LOS). PLoS ONE, 7(5):e37912.
PMID: 22655080
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Fujiwara T et al. (2011), Macrophage infiltration predicts a poor prognosis for human ewing sarcoma. Am. J. Pathol., 179(3):1157-70.
PMID: 21771572
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Cook BD et al. (2011), Smad1 signaling restricts hematopoietic potential after promoting hemangioblast commitment. Blood, 117(24):6489-97.
PMID: 21515822
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Jang HD et al. (2011), Inactivation of glycogen synthase kinase-3beta is required for osteoclast differentiation. J. Biol. Chem., 286(45):39043-50.
PMID: 21949120
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Scapini P et al. (2010), Myeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice. J. Exp. Med., 207(8):1757-73.
PMID: 20624892
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Zhang G et al. (2010), B7-h3 augments the inflammatory response and is associated with human sepsis. J. Immunol., 185(6):3677-84.
PMID: 20696859
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Kulkarni RN et al. (2010), Inhibition of osteoclastogenesis by mechanically loaded osteocytes: involvement of MEPE. Calcif. Tissue Int., 87(5):461-8.
PMID: 20725825
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Shanmugarajan S et al. (2010), Osteoclast inhibitory peptide-1 binding to the Fc gammaRIIB inhibits osteoclast differentiation. Endocrinology, 151(9):4389-99.
PMID: 20610564
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Wang L et al. (2009), Substance P stimulates bone marrow stromal cell osteogenic activity, osteoclast differentiation, and resorption activity in vitro. Bone, 45(2):309-20.
PMID: 19379851
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Binder NB et al. (2009), Estrogen-dependent and C-C chemokine receptor-2-dependent pathways determine osteoclast behavior in osteoporosis. Nat. Med., 15(4):417-24.
PMID: 19330010
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Kiuru M et al. (2009), Transient overexpression of sonic hedgehog alters the architecture and mechanical properties of trabecular bone. J. Bone Miner. Res., 24(9):1598-607.
PMID: 19338448
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Walker EC et al. (2008), Cardiotrophin-1 is an osteoclast-derived stimulus of bone formation required for normal bone remodeling. J. Bone Miner. Res., 23(12):2025-32.
PMID: 18665789
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Krum SA et al. (2008), Estrogen protects bone by inducing Fas ligand in osteoblasts to regulate osteoclast survival. EMBO J., 27(3):535-45.
PMID: 18219273
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Jinushi M et al. (2008), Milk fat globule EGF-8 promotes melanoma progression through coordinated Akt and twist signaling in the tumor microenvironment. Cancer Res., 68(21):8889-98.
PMID: 18974133
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Kovacic N et al. (2007), The Fas/Fas ligand system inhibits differentiation of murine osteoblasts but has a limited role in osteoblast and osteoclast apoptosis. J. Immunol., 178(6):3379-89.
PMID: 17339432
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Johansson MK et al. (2007), Hematopoietic stem cell-targeted neonatal gene therapy reverses lethally progressive osteopetrosis in oc/oc mice. Blood, 109(12):5178-85.
PMID: 17332244
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Niki Y et al. (2007), Administration of cyclooxygenase-2 inhibitor reduces joint inflammation but exacerbates osteopenia in IL-1 alpha transgenic mice due to GM-CSF overproduction. J. Immunol., 179(1):639-46.
PMID: 17579086
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Nakanishi M et al. (2007), Microglia-derived interleukin-6 and leukaemia inhibitory factor promote astrocytic differentiation of neural stem/progenitor cells. Eur. J. Neurosci., 25(3):649-58.
PMID: 17328769
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

O'Sullivan S et al. (2007), Imatinib promotes osteoblast differentiation by inhibiting PDGFR signaling and inhibits osteoclastogenesis by both direct and stromal cell-dependent mechanisms. J. Bone Miner. Res., 22(11):1679-89.
PMID: 17663639
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Islam S et al. (2007), Bacterial lipopolysaccharide induces osteoclast formation in RAW 264.7 macrophage cells. Biochem. Biophys. Res. Commun., 360(2):346-51.
PMID: 17597583
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Jia D et al. (2006), Glucocorticoids act directly on osteoclasts to increase their life span and reduce bone density. Endocrinology, 147(12):5592-9.
PMID: 16935844
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Mohamedali KA et al. (2006), Inhibition of prostate tumor growth and bone remodeling by the vascular targeting agent VEGF121/rGel. Cancer Res., 66(22):10919-28.
PMID: 17108129
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Kim SY et al. (2006), Bone marrow-derived cells require a functional glucose 6-phosphate transporter for normal myeloid functions. J. Biol. Chem., 281(39):28794-801.
PMID: 16891306
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

de Vries TJ et al. (2006), Gingival fibroblasts are better at inhibiting osteoclast formation than periodontal ligament fibroblasts. J. Cell. Biochem., 98(2):370-82.
PMID: 16440316
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Ponomarev ED et al. (2005), Development of a culture system that supports adult microglial cell proliferation and maintenance in the resting state. J. Immunol. Methods, 300(1):32-46.
PMID: 15893321
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Gevrey JC et al. (2005), Syk is required for monocyte/macrophage chemotaxis to CX3CL1 (Fractalkine). J. Immunol., 175(6):3737-45.
PMID: 16148119
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Conway JG et al. (2005), Inhibition of colony-stimulating-factor-1 signaling in vivo with the orally bioavailable cFMS kinase inhibitor GW2580. Proc. Natl. Acad. Sci. U.S.A., 102(44):16078-83.
PMID: 16249345
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Sharif MN et al. (2004), IFN-alpha priming results in a gain of proinflammatory function by IL-10: implications for systemic lupus erythematosus pathogenesis. J. Immunol., 172(10):6476-81.
PMID: 15128840
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Miller YI et al. (2002), Minimally modified LDL binds to CD14, induces macrophage spreading via TLR4/MD-2, and inhibits phagocytosis of apoptotic cells. J. Biol. Chem., 278(3):1561-8.
PMID: 12424240
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Subramanian K et al. (0), Pneumolysin binds to the mannose receptor C type 1 (MRC-1) leading to anti-inflammatory responses and enhanced pneumococcal survival. Nat Microbio0(0).
PMID: 30420782

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