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VMAT2 Products
The vesicular monoamine transporter 2 (VMAT2; also known as VAT2 and SCL18A) is a 55 - 75 kDa member of the vesicular transporter family, a major facilitator superfamily. VMAT2 is a 12 transmembrane (TM) glycoprotein that is found in the membrane of brain neurosecretory vesicles. It transports monoamines (dopamine, serotonin, and particularly histamine) from the cytosol into secretion vesicles by exchanging two H+ ions for one molecule of amine.
Human VMAT2 is 514 amino acids (aa) in length. It contains a 20 aa and 52 aa N- and C-terminal cytoplasmic domain, plus an extended 88 aa luminal loop between aa 42 - 129. There is one luminal, intrachain disulfide bond that contributes to amine transport (C126 - C333). In addition, residues in TM domains 5 - 8 (aa 220 - 352) and 9 - 12 (aa 358 - 462) also contribute to high affinity ligand interaction. VMAT2 is constitutively phosphorylated by CKII on S511 and S513. Within the cytoplasmic C-terminus, human VMAT2 is 94% aa identical to rat VMAT2.
16 results for "VMAT2" in Products
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VMAT2 Products
The vesicular monoamine transporter 2 (VMAT2; also known as VAT2 and SCL18A) is a 55 - 75 kDa member of the vesicular transporter family, a major facilitator superfamily. VMAT2 is a 12 transmembrane (TM) glycoprotein that is found in the membrane of brain neurosecretory vesicles. It transports monoamines (dopamine, serotonin, and particularly histamine) from the cytosol into secretion vesicles by exchanging two H+ ions for one molecule of amine.
Human VMAT2 is 514 amino acids (aa) in length. It contains a 20 aa and 52 aa N- and C-terminal cytoplasmic domain, plus an extended 88 aa luminal loop between aa 42 - 129. There is one luminal, intrachain disulfide bond that contributes to amine transport (C126 - C333). In addition, residues in TM domains 5 - 8 (aa 220 - 352) and 9 - 12 (aa 358 - 462) also contribute to high affinity ligand interaction. VMAT2 is constitutively phosphorylated by CKII on S511 and S513. Within the cytoplasmic C-terminus, human VMAT2 is 94% aa identical to rat VMAT2.
16 results for "VMAT2" in Products
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #899327 |
| Applications : | CyTOF-ready, Flow Cytometry, Immunohistochemistry, Western Blot |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #899327 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #899327 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #899327 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #899327 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #899327 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #899327 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #899327 |
| Applications : | Flow Cytometry |
Fluorescent substrate for NET and VMAT2
| Chemical Name : | 3-(2-Aminoethyl)-8-fluoro-7-hydroxy-2H-chromen-2-one hydrochloride |
| Purity : | ≥98% (HPLC) |
Selective fluorescent VMAT2 substrate
| Chemical Name : | 4-(2-Aminoethyl)-7-amino-2H-1-benzopyran-2-one dihydrochloride |
| Purity : | ≥98% (HPLC) |
Selective fluorescent substrate of DAT and VMAT2
| Chemical Name : | 4-(2-Aminoethyl)-6-chloro-7-hydroxy-2H-1-benzopyran-2-one methanesulfonate |
| Purity : | ≥99% (HPLC) |
Fluorescent substrate for VMAT2
| Chemical Name : | 9-(2-Aminoethyl)-2,3,6,7-tetrahydro-1H,5H,11H-[1]-benzopyrano[6,7,8-ij]quinolizin-11-one |
| Purity : | ≥99% (HPLC) |
Fluorescent VMAT2 substrate
| Chemical Name : | 4-(2-Aminoethyl)-7-(methylamino)-2H-1-benzopyran-2-one dihydrochloride |
| Purity : | ≥99% (HPLC) |
Inhibitor of vesicular monoamine transport
| Chemical Name : | (3β,16β,17α,18β,20α)-11,17-Dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylic acid methyl ester |
| Purity : | ≥99% (HPLC) |
Potent inhibitor of vesicular monoamine transport
| Chemical Name : | (3R,11bR)-rel-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-one |
| Purity : | ≥98% (HPLC) |
