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VMAT2 Products

The vesicular monoamine transporter 2 (VMAT2; also known as VAT2 and SCL18A) is a 55 - 75 kDa member of the vesicular transporter family, a major facilitator superfamily. VMAT2 is a 12 transmembrane (TM) glycoprotein that is found in the membrane of brain neurosecretory vesicles. It transports monoamines (dopamine, serotonin, and particularly histamine) from the cytosol into secretion vesicles by exchanging two H+ ions for one molecule of amine.

Human VMAT2 is 514 amino acids (aa) in length. It contains a 20 aa and 52 aa N- and C-terminal cytoplasmic domain, plus an extended 88 aa luminal loop between aa 42 - 129. There is one luminal, intrachain disulfide bond that contributes to amine transport (C126 - C333). In addition, residues in TM domains 5 - 8 (aa 220 - 352) and 9 - 12 (aa 358 - 462) also contribute to high affinity ligand interaction. VMAT2 is constitutively phosphorylated by CKII on S511 and S513. Within the cytoplasmic C-terminus, human VMAT2 is 94% aa identical to rat VMAT2.

17 results for "VMAT2" in Products

VMAT2 Products

The vesicular monoamine transporter 2 (VMAT2; also known as VAT2 and SCL18A) is a 55 - 75 kDa member of the vesicular transporter family, a major facilitator superfamily. VMAT2 is a 12 transmembrane (TM) glycoprotein that is found in the membrane of brain neurosecretory vesicles. It transports monoamines (dopamine, serotonin, and particularly histamine) from the cytosol into secretion vesicles by exchanging two H+ ions for one molecule of amine.

Human VMAT2 is 514 amino acids (aa) in length. It contains a 20 aa and 52 aa N- and C-terminal cytoplasmic domain, plus an extended 88 aa luminal loop between aa 42 - 129. There is one luminal, intrachain disulfide bond that contributes to amine transport (C126 - C333). In addition, residues in TM domains 5 - 8 (aa 220 - 352) and 9 - 12 (aa 358 - 462) also contribute to high affinity ligand interaction. VMAT2 is constitutively phosphorylated by CKII on S511 and S513. Within the cytoplasmic C-terminus, human VMAT2 is 94% aa identical to rat VMAT2.

17 results for "VMAT2" in Products

WB, Flow, IHC, CyTOF-ready
Catalog #: FAB8327G
Flow
Catalog #: FAB8327R
Flow
Catalog #: FAB8327S
Flow
Catalog #: RDC0481
Catalog #: FAB8327U
Flow
Catalog #: FAB8327N
Flow
Catalog #: FAB8327V
Flow
Catalog #: FAB8327T
Flow

Stains exposed epithelium in eye. Also VGlut and VMAT inhibitor

Selective fluorescent VMAT2 substrate

Fluorescent VMAT2 substrate

Fluorescent substrate for VMAT2

Fluorescent substrate for NET and VMAT2

Selective fluorescent substrate of DAT and VMAT2

Potent inhibitor of vesicular monoamine transport

Inhibitor of vesicular monoamine transport

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