Reserpine
Tocris Bioscience, part of Bio-Techne | Catalog # 2742
Inhibitor of vesicular monoamine transport
Key Product Details
Description
Inhibitor of vesicular monoamine transport
Product Description
Binds the vesicular monoamine transporter (VMAT2) and inhibits transport of biogenic amines into adrenal chromaffin granules and synaptic vesicles. Causes depletion of biogenic amine stores. Antihypertensive and antipsychotic.Product Specifications
Molecular Weight
608.68
Formula
C33H40N2O9
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
(3β,16β,17α,18β,20α)-11,17-Dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylic acid methyl ester
CAS Number
50-55-5
PubChem ID
5770
InChI Key
QEVHRUUCFGRFIF-MDEJGZGSSA-N
SMILES
[H][C@@](N4CC3)(C[C@@]([C@H]([C@@](OC)=O)[C@@H](OC)[C@H](OC(C6=CC(OC)=C(OC)C(OC)=C6)=O)C5)([H])[C@@]5([H])C4)C2=C3C1=C(N2)C=C(OC)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 6.09 | 10 |
Preparing Stock Solutions
for Reserpine
The following data is based on the product molecular weight 608.68
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 16.43 mL | 82.14 mL | 164.29 mL |
| 0.5 mM | 3.29 mL | 16.43 mL | 32.86 mL |
| 1 mM | 1.64 mL | 8.21 mL | 16.43 mL |
| 5 mM | 0.33 mL | 1.64 mL | 3.29 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Heslop and Curzon Effect of rese. on behavioural responses to agonists at 5-HT1A, 5-HT1B, 5-HT2A, and 5-HT2C receptor subtypes. Neuropharmacology 1999 PMID: 10465692
- Metzger Inhibitory effect of rese. on DA transporter function. Eur.J.Pharmacol. 2002 PMID: 12450567
- Schuldiner Reserpine binding to a vesicular amine transporter expressed in chinese hamster ovary fibroblasts. J.Biol.Chem. 1993 PMID: 8416935
Product Specific Notices for Reserpine
For research use only
⚠ WARNING: This product can expose you to chemicals including Reserpine, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov
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