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377 results for "Thrombopoietin/Tpo" in Products
Thrombopoietin/Tpo Products
Thrombopoietin (Tpo), is a key regulator of megakaryocytopoiesis and thrombopoiesis. It is principally produced in the liver and is bound and internalized by the receptor Tpo R/c-mpl. Defects in the Tpo-Tpo R signaling pathway are associated with a variety of platelet disorders. Tpo promotes the differentiation, proliferation, and maturation of megakaryocytes and their progenitors. Tpo additionally promotes platelet production, aggregation, ECM adhesion, and activation. Aside from its hematopoietic effects, Tpo is expressed in the brain where it promotes the apoptosis of hypoxia-sensitized neurons and inhibits neuronal differentiation by blocking NGF-induced signaling.
Reactivity:
Human
Source:
NS0
Accession #:
P40225
Applications:
Bioactivity
Reactivity:
Human
Source:
E. coli
Accession #:
NP_000451.1
Applications:
Bioactivity
Reactivity:
Mouse
Source:
NS0
Accession #:
P40226
Applications:
Bioactivity
Reactivity:
Mouse
Assay Range:
62.5-4000 pg/mL (Cell Culture Supernates, Serum, EDTA Plasma, Citrate Plasma)
Applications:
ELISA
Reactivity:
Human
Assay Range:
31.2-2000 pg/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma)
Applications:
ELISA
Reactivity:
Human
Details:
Goat IgG Polyclonal
Applications:
WB, B/N
Reactivity:
Canine
Details:
Mouse IgG2B Monoclonal Clone #247002
Applications:
WB, ICC/IF
Reactivity:
Human
Assay Range:
93.8-6000 pg/mL
Applications:
ELISA
GMP Version Available:
BT-TPO-GMP
GMP
Reactivity:
Human
Source:
E. coli
Accession #:
NP_000451
Applications:
Bioactivity
Reactivity:
Human
Reactivity:
Mouse, Rat
Details:
Goat IgG Polyclonal
Applications:
WB, B/N
Reactivity:
Human
Details:
Mouse IgG2B Monoclonal Clone #34817
Applications:
ELISA(Cap), B/N
Reactivity:
Mouse
Details:
Rat IgG2A Monoclonal Clone #378120
Applications:
WB, ELISA(Cap)
Reactivity:
Human
Source:
E. coli
Accession #:
NP_000451.1
Applications:
Bioactivity
Reactivity:
Human
Applications:
ELISA, Ctrl
Reactivity:
Human
Source:
Sf 21 (baculovirus)
Accession #:
P40225
Applications:
Bioactivity
Reactivity:
Mouse
Assay Range:
62.5-4000 pg/mL
Applications:
ELISA
Reactivity:
Human
Source:
E. coli
Accession #:
NP_000451.1
Applications:
Bioactivity
Reactivity:
Human
Source:
HEK293
Accession #:
P40225.1
Applications:
Bioactivity
GMP Version Available:
BT-TPO-GMP
GMP
Reactivity:
Human
Source:
E. coli
Accession #:
NP_000451.1
Applications:
Bioactivity
Reactivity:
Human
Details:
Mouse IgG1 Monoclonal Clone #34863
Applications:
WB
Reactivity:
Human
Details:
Mouse IgG1 Monoclonal Clone #1065103
Applications:
WB
Reactivity:
Human
Details:
Mouse IgG1 Monoclonal Clone #1053909
Applications:
IHC
Reactivity:
Human
Details:
Mouse IgG1 Monoclonal Clone #1053909
Applications:
IHC