Siglec-2/CD22 Products
Siglec-2 (sialic acid binding Ig-like lectin 2), also known as CD22, is a 130-140 kDa type I transmembrane glycoprotein with seven Ig-like domains in the extracellular region and three ITIM motifs in its cytoplasmic region. Alternate splicing generates an additional isoform that lacks the third and fourth Ig-like domains. Siglec-2 is expressed on B cells, preferentially binds alpha 2-6 linked sialic glycans including CD45 and mediates B cell - B cell interactions. Phosphorylation of Tyr822 within one of the ITIMs is important for Siglec-2 signal transduction through its association with the kinases Lyn, PI 3-Kinase p85 alpha, and SYK.
614 results for "Siglec-2/CD22" in Products
614 results for "Siglec-2/CD22" in Products
Siglec-2/CD22 Products
Siglec-2 (sialic acid binding Ig-like lectin 2), also known as CD22, is a 130-140 kDa type I transmembrane glycoprotein with seven Ig-like domains in the extracellular region and three ITIM motifs in its cytoplasmic region. Alternate splicing generates an additional isoform that lacks the third and fourth Ig-like domains. Siglec-2 is expressed on B cells, preferentially binds alpha 2-6 linked sialic glycans including CD45 and mediates B cell - B cell interactions. Phosphorylation of Tyr822 within one of the ITIMs is important for Siglec-2 signal transduction through its association with the kinases Lyn, PI 3-Kinase p85 alpha, and SYK.
| Source: | NS0 |
| Accession #: | CAA42006 |
| Applications: | BA |
Fc Chimera
| Source: | NS0 |
| Accession #: | CAA42006.1 |
| Applications: | BA |
Recombinant Monoclonal Antibody. Bivalent Llama VHH domain, Human IgG2 Fusion Antibody.
| Reactivity: | Human |
| Details: | Llama Monoclonal Clone #L007.2.5H |
| Applications: | IHC, ICC |
| Reactivity: | Human, Mouse, Rat, Canine, Monkey |
| Details: | Mouse IgG1 Monoclonal Clone #OTI1F12 |
| Applications: | WB, ICC/IF |
![Western Blot: Siglec-2/CD22 Antibody (OTI1F12) [NBP2-46125]](https://resources.bio-techne.com/images/products/Siglec-2-CD22-Antibody-1F12-Western-Blot-NBP2-46125-img0003.jpg "Western Blot: Siglec-2/CD22 Antibody (OTI1F12) [NBP2-46125]")
Fc Chimera
| Source: | NS0 |
| Accession #: | CAA42006.1 |
| Applications: | BA |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #219937 |
| Applications: | WB, IHC |
| Reactivity: | Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, ICC, Neut |
Biotinylated
| Source: | CHO |
| Accession #: | CAA42006.1 |
| Applications: | BA, BA |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #2H1C4 |
| Applications: | IHC, WB, ELISA, ICC/IF, Flow |
![Western Blot: Siglec-2/CD22 Antibody (2H1C4)BSA Free [NBP2-37327]](https://resources.bio-techne.com/images/products/Siglec-2-CD22-Antibody-2H1C4-Western-Blot-NBP2-37327-img0004.jpg "Western Blot: Siglec-2/CD22 Antibody (2H1C4)BSA Free [NBP2-37327]")
| Source: | CHO |
| Accession #: | CAA42006.1 |
| Applications: | BA |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #726830 |
| Applications: | WB, ICC |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #219934 |
| Applications: | Flow, CyTOF-ready |
Biotinylated
| Source: | CHO |
| Accession #: | CAA42006.1 |
| Applications: | BA, BA |
Recombinant Monoclonal Antibody. His-tagged VHH domain.
| Reactivity: | Human |
| Details: | Llama Monoclonal Clone #L007.2.5N |
| Applications: | Flow, ICC |
| Source: | NS0 |
| Accession #: | P35329 |
| Applications: | BA |
Fc Chimera
| Source: | NS0 |
| Accession #: | CAA42006.1 |
| Applications: | BA |
| Assay Range: | 93.8 - 6,000 pg/mL |
| Applications: | ELISA |
| Reactivity: | Mouse |
| Details: | Rat IgG2a Monoclonal Clone #308501 |
| Applications: | WB, Flow, CyTOF-ready |
| Reactivity: | Mouse |
| Details: | Rat IgG2a Monoclonal Clone #308501 |
| Applications: | Flow |
| Reactivity: | Mouse |
| Details: | Rat IgG2a Monoclonal Clone #308501 |
| Applications: | Flow |
| Source: | CHO |
| Accession #: | NP_001100973.1 |
| Applications: | BA |
| Source: | CHO |
| Accession #: | NP_001100973.1 |
| Applications: | BA |
Fc Chimera
| Source: | NS0 |
| Accession #: | CAA42006.1 |
| Applications: | BA |
| Source: | HEK293 |
| Accession #: | EHH59463 |
| Applications: | BA |
| Source: | HEK293 |
| Accession #: | EHH59463 |
| Applications: | BA |
