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Siglec-2/CD22 Products
Siglec-2 (sialic acid binding Ig-like lectin 2), also known as CD22, is a 130-140 kDa type I transmembrane glycoprotein with seven Ig-like domains in the extracellular region and three ITIM motifs in its cytoplasmic region. Alternate splicing generates an additional isoform that lacks the third and fourth Ig-like domains. Siglec-2 is expressed on B cells, preferentially binds alpha 2-6 linked sialic glycans including CD45 and mediates B cell - B cell interactions. Phosphorylation of Tyr822 within one of the ITIMs is important for Siglec-2 signal transduction through its association with the kinases Lyn, PI 3-Kinase p85 alpha, and SYK.
44 results for "Siglec-2/CD22" in Products
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Siglec-2/CD22 Products
Siglec-2 (sialic acid binding Ig-like lectin 2), also known as CD22, is a 130-140 kDa type I transmembrane glycoprotein with seven Ig-like domains in the extracellular region and three ITIM motifs in its cytoplasmic region. Alternate splicing generates an additional isoform that lacks the third and fourth Ig-like domains. Siglec-2 is expressed on B cells, preferentially binds alpha 2-6 linked sialic glycans including CD45 and mediates B cell - B cell interactions. Phosphorylation of Tyr822 within one of the ITIMs is important for Siglec-2 signal transduction through its association with the kinases Lyn, PI 3-Kinase p85 alpha, and SYK.
44 results for "Siglec-2/CD22" in Products
Contains 4 membranes - each spotted in duplicate with 59 different immunoreceptor antibodies
Catalog #:
DY1968-05
ELISA
| Assay Range : | 93.8 - 6,000 pg/mL |
| Applications : | ELISA |
WB, ICC, Neut
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | Block/Neutralize, Immunocytochemistry/Immunofluorescence, Western Blot |
BA
| Source : | NS0 |
| Accession # : | CAA42006 |
| Applications : | Bioactivity |
Catalog #:
LMAB10732
Flow
Recombinant Monoclonal Antibody. His-tagged VHH domain.
| Clonality : | Monoclonal |
| Host : | Llama Clone #L007.2.5N |
| Applications : | Flow Cytometry |
Catalog #:
FAB1968G
Flow
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #219934 |
| Applications : | Flow Cytometry |
Catalog #:
10191-SL
BA
| Source : | CHO |
| Accession # : | CAA42006.1 |
| Applications : | Bioactivity |
Catalog #:
FAB1968V
Flow
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #219934 |
| Applications : | Flow Cytometry |
Catalog #:
AVI10191
BA
Biotinylated
| Source : | CHO |
| Accession # : | CAA42006.1 |
| Applications : | Bioactivity |
Catalog #:
2296-SL
BA
| Source : | NS0 |
| Accession # : | P35329 |
| Applications : | Bioactivity |
Catalog #:
10572-SL
BA
| Source : | CHO |
| Accession # : | NP_001100973.1 |
| Applications : | Bioactivity |
Catalog #:
10571-SL
BA
| Source : | CHO |
| Accession # : | NP_001100973.1 |
| Applications : | Bioactivity |
Catalog #:
MAB1968
Flow, CyTOF-ready, ICC
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #219934 |
| Applications : | CyTOF-ready, Flow Cytometry, Immunocytochemistry/Immunofluorescence |
Catalog #:
MAB19681
WB
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #219902 |
| Applications : | Western Blot |
Catalog #:
MAB2296
WB, Flow, CyTOF-ready
| Clonality : | Monoclonal |
| Host : | Rat IgG2a Clone #308501 |
| Applications : | CyTOF-ready, Flow Cytometry, Western Blot |
Catalog #:
10031-SL
BA
| Source : | HEK293 |
| Accession # : | EHH59463 |
| Applications : | Bioactivity |
BA
| Source : | HEK293 |
| Accession # : | EHH59463 |
| Applications : | Bioactivity |
