
Siglec-2/CD22 Products
Siglec-2 (sialic acid binding Ig-like lectin 2), also known as CD22, is a 130-140 kDa type I transmembrane glycoprotein with seven Ig-like domains in the extracellular region and three ITIM motifs in its cytoplasmic region. Alternate splicing generates an additional isoform that lacks the third and fourth Ig-like domains. Siglec-2 is expressed on B cells, preferentially binds alpha 2-6 linked sialic glycans including CD45 and mediates B cell - B cell interactions. Phosphorylation of Tyr822 within one of the ITIMs is important for Siglec-2 signal transduction through its association with the kinases Lyn, PI 3-Kinase p85 alpha, and SYK.
44 results for "Siglec-2/CD22" in Products
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Siglec-2/CD22 Products
Siglec-2 (sialic acid binding Ig-like lectin 2), also known as CD22, is a 130-140 kDa type I transmembrane glycoprotein with seven Ig-like domains in the extracellular region and three ITIM motifs in its cytoplasmic region. Alternate splicing generates an additional isoform that lacks the third and fourth Ig-like domains. Siglec-2 is expressed on B cells, preferentially binds alpha 2-6 linked sialic glycans including CD45 and mediates B cell - B cell interactions. Phosphorylation of Tyr822 within one of the ITIMs is important for Siglec-2 signal transduction through its association with the kinases Lyn, PI 3-Kinase p85 alpha, and SYK.
44 results for "Siglec-2/CD22" in Products
Contains 4 membranes - each spotted in duplicate with 59 different immunoreceptor antibodies
Assay Range : | 93.8 - 6,000 pg/mL |
Applications : | ELISA |
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | Block/Neutralize, Immunocytochemistry/Immunofluorescence, Western Blot |
Source : | NS0 |
Accession # : | CAA42006 |
Applications : | Bioactivity |
Recombinant Monoclonal Antibody. His-tagged VHH domain.
Clonality : | Monoclonal |
Host : | Llama Clone #L007.2.5N |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #219934 |
Applications : | Flow Cytometry |
Source : | CHO |
Accession # : | CAA42006.1 |
Applications : | Bioactivity |
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #219934 |
Applications : | Flow Cytometry |
Biotinylated
Source : | CHO |
Accession # : | CAA42006.1 |
Applications : | Bioactivity |
Source : | NS0 |
Accession # : | P35329 |
Applications : | Bioactivity |
Source : | CHO |
Accession # : | NP_001100973.1 |
Applications : | Bioactivity |
Source : | CHO |
Accession # : | NP_001100973.1 |
Applications : | Bioactivity |
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #219934 |
Applications : | CyTOF-ready, Flow Cytometry, Immunocytochemistry/Immunofluorescence |
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #219902 |
Applications : | Western Blot |
Clonality : | Monoclonal |
Host : | Rat IgG2a Clone #308501 |
Applications : | CyTOF-ready, Flow Cytometry, Western Blot |
Source : | HEK293 |
Accession # : | EHH59463 |
Applications : | Bioactivity |
Source : | HEK293 |
Accession # : | EHH59463 |
Applications : | Bioactivity |