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Siglec-2/CD22 Products

Siglec-2 (sialic acid binding Ig-like lectin 2), also known as CD22, is a 130-140 kDa type I transmembrane glycoprotein with seven Ig-like domains in the extracellular region and three ITIM motifs in its cytoplasmic region. Alternate splicing generates an additional isoform that lacks the third and fourth Ig-like domains. Siglec-2 is expressed on B cells, preferentially binds alpha 2-6 linked sialic glycans including CD45 and mediates B cell - B cell interactions. Phosphorylation of Tyr822 within one of the ITIMs is important for Siglec-2 signal transduction through its association with the kinases Lyn, PI 3-Kinase p85 alpha, and SYK.

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257 results for "Siglec-2/CD22" in Products

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Siglec-2/CD22 Products

Siglec-2 (sialic acid binding Ig-like lectin 2), also known as CD22, is a 130-140 kDa type I transmembrane glycoprotein with seven Ig-like domains in the extracellular region and three ITIM motifs in its cytoplasmic region. Alternate splicing generates an additional isoform that lacks the third and fourth Ig-like domains. Siglec-2 is expressed on B cells, preferentially binds alpha 2-6 linked sialic glycans including CD45 and mediates B cell - B cell interactions. Phosphorylation of Tyr822 within one of the ITIMs is important for Siglec-2 signal transduction through its association with the kinases Lyn, PI 3-Kinase p85 alpha, and SYK.

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257 results for "Siglec-2/CD22" in Products

BA

Fc Chimera

Flow, CyTOF-ready, ICC
ELISA, Flow, ICC/IF, IHC, WB
WB, ICC, Neut
BA
BA

Fc Chimera

IHC, ICC

Recombinant Monoclonal Antibody. Bivalent Llama VHH domain, Human IgG2 Fusion Antibody.

Catalog #: MAB2296
WB, Flow, CyTOF-ready
BA, BA

Biotinylated

BA, BA

Biotinylated

ICC

Recombinant Monoclonal Antibody. His-tagged VHH domain.

BA

Fc Chimera

ELISA
Catalog #: FAB2296N
Flow
ELISA, Flow, ICC/IF, IHC, MA, WB
BA

Fc Chimera

BA
Flow
WB, ICC
Flow, ICC

Recombinant Monoclonal Antibody. His-tagged VHH domain.

Catalog #: FAB1968T
Flow
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