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Siglec-2/CD22 Products

Siglec-2 (sialic acid binding Ig-like lectin 2), also known as CD22, is a 130-140 kDa type I transmembrane glycoprotein with seven Ig-like domains in the extracellular region and three ITIM motifs in its cytoplasmic region. Alternate splicing generates an additional isoform that lacks the third and fourth Ig-like domains. Siglec-2 is expressed on B cells, preferentially binds alpha 2-6 linked sialic glycans including CD45 and mediates B cell - B cell interactions. Phosphorylation of Tyr822 within one of the ITIMs is important for Siglec-2 signal transduction through its association with the kinases Lyn, PI 3-Kinase p85 alpha, and SYK.

44 results for "Siglec-2/CD22" in Products

Siglec-2/CD22 Products

Siglec-2 (sialic acid binding Ig-like lectin 2), also known as CD22, is a 130-140 kDa type I transmembrane glycoprotein with seven Ig-like domains in the extracellular region and three ITIM motifs in its cytoplasmic region. Alternate splicing generates an additional isoform that lacks the third and fourth Ig-like domains. Siglec-2 is expressed on B cells, preferentially binds alpha 2-6 linked sialic glycans including CD45 and mediates B cell - B cell interactions. Phosphorylation of Tyr822 within one of the ITIMs is important for Siglec-2 signal transduction through its association with the kinases Lyn, PI 3-Kinase p85 alpha, and SYK.

44 results for "Siglec-2/CD22" in Products

Contains 4 membranes - each spotted in duplicate with 59 different immunoreceptor antibodies

BA

Fc Chimera

ELISA
WB, ICC, Neut
Flow

Recombinant Monoclonal Antibody. His-tagged VHH domain.

Flow
BA
Catalog #: FAB1968V
Flow
Catalog #: RDC1552
Catalog #: RDC2253
BA

Biotinylated

BA

Fc Chimera

BA

Biotinylated

BA
BA
BA
BA

Fc Chimera

BA

Fc Chimera

Flow, CyTOF-ready, ICC
WB
Catalog #: MAB2296
WB, Flow, CyTOF-ready
BA
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