Skip to main content

Siglec-2/CD22: Antibodies

Siglec-2 (sialic acid binding Ig-like lectin 2), also known as CD22, is a 130-140 kDa type I transmembrane glycoprotein with seven Ig-like domains in the extracellular region and three ITIM motifs in its cytoplasmic region. Alternate splicing generates an additional isoform that lacks the third and fourth Ig-like domains. Siglec-2 is expressed on B cells, preferentially binds alpha 2-6 linked sialic glycans including CD45 and mediates B cell - B cell interactions. Phosphorylation of Tyr822 within one of the ITIMs is important for Siglec-2 signal transduction through its association with the kinases Lyn, PI 3-Kinase p85 alpha, and SYK.

24 results for "Siglec-2/CD22 Primary Antibodies" in Products

Siglec-2/CD22: Antibodies

Siglec-2 (sialic acid binding Ig-like lectin 2), also known as CD22, is a 130-140 kDa type I transmembrane glycoprotein with seven Ig-like domains in the extracellular region and three ITIM motifs in its cytoplasmic region. Alternate splicing generates an additional isoform that lacks the third and fourth Ig-like domains. Siglec-2 is expressed on B cells, preferentially binds alpha 2-6 linked sialic glycans including CD45 and mediates B cell - B cell interactions. Phosphorylation of Tyr822 within one of the ITIMs is important for Siglec-2 signal transduction through its association with the kinases Lyn, PI 3-Kinase p85 alpha, and SYK.

24 results for "Siglec-2/CD22 Primary Antibodies" in Products

Flow

Recombinant Monoclonal Antibody. His-tagged VHH domain.

Recombinant Monoclonal Antibody. Bivalent Llama VHH domain, Human IgG2 Fusion Antibody.

WB, ICC, Neut
ELISA
WB, ICC
ELISA
Flow, CyTOF-ready, ICC
WB
Catalog #: MAB2296
WB, Flow, CyTOF-ready
Flow
Catalog #: FAB1968T
Flow
Catalog #: FAB2296N
Flow
Catalog #: FAB1968N
Flow
Neut
Catalog #: FAB1968R
Flow
Catalog #: FAB2296R
Flow
Catalog #: FAB1968V
Flow
Catalog #: FAB2296V
Flow
Catalog #: FAB2296U
Flow
Catalog #: FAB2296S
Flow
Catalog #: FAB2296T
Flow
Catalog #: FAB1968U
Flow
Catalog #: FAB2296G
Flow
Catalog #: FAB1968S
Flow
/ 1
Results Per Page
5 10 25 50