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Presenilin-1 Products

Presenilin-1 (PS-1) and Presenilin-2 (PS-2) are integral membrane proteins that contain multiple transmembrane domains. Both are predominantly located within the endoplasmic reticulum (ER) and early Golgi apparatus. They are primarily expressed in neurons and are ubiquitously expressed in the brain. PS-1 and PS-2 are proteolytically cleaved to generate an N-terminal fragment (NTF) and a C-terminal fragment (CTF). Mutations in the gene for Presenilin may play an important role in the pathology of Alzheimer's disease.

17 results for "Presenilin-1" in Products

Presenilin-1 Products

Presenilin-1 (PS-1) and Presenilin-2 (PS-2) are integral membrane proteins that contain multiple transmembrane domains. Both are predominantly located within the endoplasmic reticulum (ER) and early Golgi apparatus. They are primarily expressed in neurons and are ubiquitously expressed in the brain. PS-1 and PS-2 are proteolytically cleaved to generate an N-terminal fragment (NTF) and a C-terminal fragment (CTF). Mutations in the gene for Presenilin may play an important role in the pathology of Alzheimer's disease.

17 results for "Presenilin-1" in Products

Gamma γ-secretase inhibitor; induces neuronal differentiation; blocks Notch signaling

DAPT synthesized to Ancillary Material Grade

γ-secretase inhibitor; inhibits Notch pathway

Contains 4 membranes - each spotted in duplicate with 35 different protease antibodies

WB, IHC, KO

Contains 4 membranes-2 spotted in duplicate with antibodies against 35 different proteases and 2 spotted in duplicate with antibodies against 32 different protease inhibitors

WB, IHC
Catalog #: BAF149
WB
Catalog #: MAB1491
WB
Catalog #: RDC0942

Potent γ-secretase inhibitor

γ-secretase inhibitor; attenuates amyloid plaque deposition

Potent γ-secretase inhibitor

γ-secretase pseudo-inhibitor

Highly potent γ-secretase inhibitor; orally bioavailable

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