9 results for "Nicotinic (a4b2) Receptor Agonists Small Molecules and Peptides" in Products
Nicotinic (a4b2) Receptor Agonists: Small Molecules and Peptides
Nicotinic α4β2 receptors have high affinity for nicotine and account for >90% of [3H]-nicotine binding to brain tissues. A stoichiometry of (α4)2(β2)3 has been proposed, generating two agonist binding sites consistent with the model of the muscle nAChR.
Manipulation of the stoichiometry of α4β2 nAChRs expressed in Xenopus oocytes indicates that (α4)3(β2)2 nAChRs are also viable, displaying lower affinity for ACh and higher Ca2+ permeability; whether ...
Prototypical nAChR agonist
| Chemical Name: | (S)-(-)-1-Methyl-2-(3-pyridyl)pyrrolidine (L-(+))-ditartrate salt |
| Purity: | ≥99% (HPLC) |
Selective α4β2 nAChR partial agonist; orally active
| Chemical Name: | 7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine tartrate |
| Purity: | ≥99% (HPLC) |
Highly potent PSAM4-GlyR and PSAM4-5-HT3 chimeric ion channel agonist; brain-penetrant
| Chemical Name: | 1-Methyl-7,8,9,10-tetrahydro-1H-6,10-methanoazepino[4,5-g]quinoxalin-2(6H)-one hydrochloride |
| Purity: | ≥98% (HPLC) |
Selective α4β2 nAChR agonist
| Alternate Names: | Tebanicline |
| Chemical Name: | (R)-5-(Azetidin-2-ylmethoxy)-2-chloropyridine hydrochloride |
| Purity: | ≥98% (HPLC) |
Potent α4β4, α4β2 and α7 nAChR agonist
| Chemical Name: | (1R,5S)-9-Bromo-1,2,3,4,5,6-hexahydro-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one |
| Purity: | ≥98% (HPLC) |
Selective α4β2 nAChR agonist
| Alternate Names: | Metanicotine,TC-2403 |
| Chemical Name: | (E)-N-Methyl-4-(3-pyridinyl)-3-buten-1-amine oxalate |
| Purity: | ≥99% (HPLC) |
Selective α4β2 nAChR partial agonist
| Chemical Name: | 4-(5-ethoxy-3-pyridinyl)-N-methyl-(3E)-3-buten-1-amine difumarate |
| Purity: | ≥98% (HPLC) |
Potent positive allosteric modulator of α4β2 nAChRs; also inhibitor of (α4)2(β2)3, muscle-type and Torpedo nAChRs
| Chemical Name: | 3-(2-Chlorophenyl)-5-(5-methyl-1-(piperidin-4-yl)-1H-pyrazol-4-yl)isoxazole hydrochloride |
| Purity: | ≥98% (HPLC) |
High affinity and selective α4β2 nAChR partial agonist
| Chemical Name: | 2-Methyl-3-[(2S)-pyrrolidinylmethoxy]pyridine dihydrochloride |
| Purity: | ≥98% (HPLC) |
