RJR 2403 oxalate

Name: RJR 2403 oxalate
Brand: Tocris Bioscience
SKU: 1053

Catalog # 1053

Citations (6)

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$35 to United States

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Key Product Details

Description:	Selective α4β2 nAChR agonist
Alternative Names:	Metanicotine, TC-2403
Chemical Name:	(E)-N-Methyl-4-(3-pyridinyl)-3-buten-1-amine oxalate
Purity:	≥99% (HPLC)
Molecular Weight:	252.27

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Biological Activity

RJR 2403 oxalate is a neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype (K_i values are 26 and 36000 nM for α4β2 and α7 receptors respectively). Active in vivo.

Technical Data

M. Wt	252.27
Formula	C₁₀H₁₄N₂.C₂H₂O₄
Storage	Desiccate at +4°C
Purity	≥99% (HPLC)
CAS Number	220662-95-3
PubChem ID	23298272
InChi Key	WTIZFOAIQXMQHC-DPZBITMOSA-N
Smiles	O=C(O)C(O)=O.CNCC/C=C/C1=CC=CN=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	25.23	100

Preparing Stock Solutions

The following data is based on the product molecular weight 252.27.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.96 mL	19.82 mL	39.64 mL
5 mM	0.79 mL	3.96 mL	7.93 mL
10 mM	0.40 mL	1.98 mL	3.96 mL
50 mM	0.08 mL	0.40 mL	0.79 mL

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References

References are publications that support the biological activity of the product.

Damaj Antinociceptive and pharmacological effects of metanicotine, a selective nicotinic agonist. J.Pharmacol.Exp.Ther. 1999 PMID: 10490929
Bencherif RJR-2403: a nicotinic agonist with CNS selectivity I. In vitro characterization. J.Pharmacol.Exp.Ther. 1996 PMID: 8968366
Lippiello RJR-2403: a nicotinic agonist with CNS selectivity II. In vivo characterization. J.Pharmacol.Exp.Ther. 1996 PMID: 8968367

Citations for RJR 2403 oxalate (6)

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Citations are publications that use Bio-Techne products. Selected citations for RJR 2403 oxalate include:

Kiss et al. (2014) Nicotinic acetylcholine receptors containing the α7-like subunit mediate contractions of muscles responsible for space positioning of the snail, Helix pomatia L. tentacle. PLoS One. 9:e109538
PMID: 25303328
Zhong et al. (2013) Nicotine elicits prolonged calcium signaling along ventral hippocampal axons. Dev Neurobiol. 8:e82719
PMID: 24349346
Zakharova et al. (2011) Chronic cerebral ischaemia forms new cholinergic mechanisms of learning and memory. Int J Alzheimers Dis. 2010:954589
PMID: 21197444
Scholze et al. (2011) α4β2 nicotinic acetylcholine receptors in the early postnatal mouse superior cervical ganglion. Cardiovasc Res. 71:390
PMID: 21485013
Liu et al. (2009) A novel nicotinic acetylcholine receptor subtype in basal forebrain cholinergic neurons with high sensitivity to amyloid peptides. J Neurosci. 29:918
PMID: 19176801
Li et al. (2009) Specific subtypes of nicotinic cholinergic receptors involved in sympathetic and parasympathetic cardiovascular responses. Neurosci Lett. 462:20
PMID: 19573576

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