ABT 594 hydrochloride

Name: ABT 594 hydrochloride
Brand: Tocris Bioscience
SKU: 6576

Tocris Bioscience, part of Bio-Techne | Catalog # 6576

COA / SDS

Selective α4β2 nAChR agonist

Key Product Details

Description:	Selective α4β2 nAChR agonist
Alternative Names:	Tebanicline
Chemical Name:	(R)-5-(Azetidin-2-ylmethoxy)-2-chloropyridine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	235.11

View Full Technical Details for ABT 594 hydrochloride

Technical Data
Citations

Biological Activity for ABT 594 hydrochloride

ABT 594 hydrochloride is a selective α4β2 nAChR agonist (EC₅₀ = 140 nM for human α4β2 nAChRs, in vitro). Exhibits >900-fold selectivity for α4β2 nAChRs over other neurotransmitter receptors. Displays analgesic properties in various animal models of pain. Potentiates gabapentin mediated analgesia. Also demonstrates cognitive enhancement effects in rodent model of attention deficit.

Compound Libraries for ABT 594 hydrochloride

ABT 594 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ABT 594 hydrochloride

M. Wt	235.11
Formula	C₉H₁₁ClN₂O.HCL
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	203564-54-9
PubChem ID	72193963
InChi Key	GYVARJONEFSAJB-OGFXRTJISA-N
Smiles	ClC1=NC=C(C=C1)OC[C@H]2CCN2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ABT 594 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	23.51	100
	DMSO	23.51	100

Preparing Stock Solutions for ABT 594 hydrochloride

The following data is based on the product molecular weight 235.11.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.25 mL	21.27 mL	42.53 mL
5 mM	0.85 mL	4.25 mL	8.51 mL
10 mM	0.43 mL	2.13 mL	4.25 mL
50 mM	0.09 mL	0.43 mL	0.85 mL

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Reconstitution Calculator

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References for ABT 594 hydrochloride

References are publications that support the biological activity of the product.

Mar MAM-E17 rat model impairments on a novel continuous performance task: effects of potential cognitive enhancing drugs. Psychopharmacology (Berl) 2017 PMID: 28744563
Lynch ABT-594 (a nicotinic acetylcholine agonist): anti-allodynia in a rat chemotherapy-induced pain model. Eur.J.Pharmacol. 2005 PMID: 15713428
Munro Selective potentiation of gabapentin-mediated antinociception in the rat formalin test by the nicotinic acetylcholine receptor agonist ABT-594. Neuropharmacology 2010 PMID: 20562022
Donnelly-Roberts ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: a novel, orally effective analgesic acting via neuronal nicotinic acetylcholine receptors: I. In vitro characterization. J.Pharmacol.Exp.Ther. 1998 PMID: 9580626