TC 2559 difumarate
Tocris Bioscience, part of Bio-Techne | Catalog # 2737
Selective α4β2 nAChR partial agonist
Key Product Details
Description
Selective α4β2 nAChR partial agonist
Product Description
TC 2559 difumarate is a subtype-selective partial agonist for α4β2 nicotinic acetylcholine receptors (EC50 values are 0.18, 12.5, 14.0, > 30, > 100 and > 100 μM for α4β2, α4β4, α2β4, α3β4, α3β2 and α7 receptor subtypes respectively). Displays selectivity for (α4)2(β2)3 receptor stoichiometry and enhanced CNS-PNS selectivity ratio. Attenuates scopolamine-induced cognitive deficits in a step-through passive avoidance task.Product Specifications
Molecular Weight
438.43
Formula
C12H18N2O.2C4H4O4
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
4-(5-ethoxy-3-pyridinyl)-N-methyl-(3E)-3-buten-1-amine difumarate
CAS Number
2454492-41-0
PubChem ID
56972184
InChI Key
GEWVPSJQGJBDLM-MYBAKCFCSA-N
SMILES
CCOC1=CN=CC(/C=C/CCNC)=C1.O=C(O)/C=C/C(O)=O.O=C(O)/C=C/C(O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 43.84 | 100 |
Preparing Stock Solutions
for TC 2559 difumarate
The following data is based on the product molecular weight 438.43
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.28 mL | 11.40 mL | 22.81 mL |
| 5 mM | 0.46 mL | 2.28 mL | 4.56 mL |
| 10 mM | 0.23 mL | 1.14 mL | 2.28 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Chen The nicotinic α4β2 receptor selective agonist, TC-2559, increases DA neuronal activity in the ventral tegmental area of rat midbrain slices. Neuropharmacology 2003 PMID: 12871651
- Zwart 5-I A-85380 and TC-2559 differentially activate heterologously expressed α4β2 nicotinic receptors. Eur.J.Pharmacol. 2006 PMID: 16674940
- Bencherif TC-2559: a novel orally active ligand selective at neuronal acetylcholine receptors. Eur.J.Pharmacol. 2000 PMID: 11099699
Product Specific Notices for TC 2559 difumarate
For research use only
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