(-)-Nicotine ditartrate

Name: (-)-Nicotine ditartrate
Brand: Tocris Bioscience
SKU: 3546

Tocris Bioscience a Bio-Techne Brand

Catalog # 3546

Citations (7)

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Key Product Details

Description:	Prototypical nAChR agonist
Chemical Name:	(S)-(-)-1-Methyl-2-(3-pyridyl)pyrrolidine (+)-ditartrate salt
Purity:	≥99% (HPLC)
Molecular Weight:	462.41

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Biological Activity for (-)-Nicotine ditartrate

(-)-Nicotine ditartrate is a nicotinic acetylcholine receptor (nAChR) agonist (K_i values are 1, > 1000, 4000 and 7130 nM at α4β2, α1β1δγ, rat α7 and human α7 respectively). Exhibits vasoconstrictive, hypertensive and prothrombotic activity in vivo.

Technical Data for (-)-Nicotine ditartrate

M. Wt	462.41
Formula	C₁₀H₁₄N₂.2C₄H₆O₆
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	65-31-6
PubChem ID	11957628
InChi Key	RFEJUZJILGIRHQ-OMDKHLBYSA-N
Smiles	CN(CCC2)[C@@H]2[C@]1=CC=CN=C1.OC([C@H](O)[C@@H](O)C(O)=O)=O.OC([C@H](O)[C@@H](O)C(O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (-)-Nicotine ditartrate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	46.24	100
	DMSO	34.68	75

Preparing Stock Solutions for (-)-Nicotine ditartrate

The following data is based on the product molecular weight 462.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.16 mL	10.81 mL	21.63 mL
5 mM	0.43 mL	2.16 mL	4.33 mL
10 mM	0.22 mL	1.08 mL	2.16 mL
50 mM	0.04 mL	0.22 mL	0.43 mL

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References for (-)-Nicotine ditartrate

References are publications that support the biological activity of the product.

Mayhan Acute infusion of nicotine potentiates NE-induced vasoconstriction in the hamster cheek pouch. J.Lab.Clin.Med. 1999 PMID: 10385481
Donnelly-Roberts ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: A novel, orally effective analgesic acting via neuronal nicotinic acetylcholine receptors: I In vitro characterization. J.Pharmacol.Exp.Ther. 1998 PMID: 9580626
Xiao Rat α3/β4 subtype of neuronal nicotinic acetylcholine receptor stably expressed in a transfected cell line: Pharmacology of ligand binding and function. Mol.Pharmacol. 1998 PMID: 9687574

Citations for (-)-Nicotine ditartrate (7)

Showing 1 - 7 of 7 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for (-)-Nicotine ditartrate include:

Dorst et al. (2020) Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner. Nat Commun. 11:5113
PMID: 33037215
Gu et al. (2019) α6-Containing Nicotinic Acetylcholine Receptor Reconstitution Involves Mechanistically Distinct Accessory Components. Cell Rep. 26:866
PMID: 30673609
Miguel Angel Garcia-Bereguiain et al. (2016) Spontaneous Release Regulates Synaptic Scaling in the Embryonic Spinal Network In Vivo The Journal of Neuroscience. 6:7268
PMID: 27383600
Tang et al. (2015) Identification and in vitro pharmacological characterization of a novel and selective α7 nicotinic acetylcholine receptor agonist, Br-IQ17B. Iran Biomed J. 36:800
PMID: 25948478
Chalabi-Yani et al. (2015) Effect of Transient Inactivation of Ventral Tegmental Area on the Expression and Acquisition of Nicotine-Induced Conditioned Place Preference in Rats. Elife. 19:214
PMID: 26210948
Leão et al. (2012) OLM interneurons differentially modulate CA3 and entorhinal inputs to hippocampal CA1 neurons. Nat Neurosci. 15:1524
PMID: 23042082
Owaisat et al. (2012) In vivo comparison of harmine efficacy against psychostimulants: preferential inhibition of the cocaine response through a glutamatergic mechanism. Neurosci Lett. 525:12
PMID: 22877698

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