411 results for "LDLR" in Products
LDLR Products
LDLR (Low Density Lipoprotein Receptor) is a widely expressed cell surface scavenger receptor. LDLR binds ApoB and ApoE, the apolipoproteins of low- and very low-density lipoproteins (LDL and VLDL), respectively. Hepatocyte LDLR is responsible for endocytosis and clearing of most plasma LDL cholesterol. At the low pH of the endocytic vesicle, it dissociates, allowing degradation of LDL and recycling of LDLR to the cell surface. Lack of LDLR expression or function causes familial hypercholesterolemia (FH). The protease PCSK9 can also cause increased plasma cholesterol by promoting LDLR degradation rather than recycling to the cell surface.
Simple Plex cartridges are custom built to fit your needs. Choose from over 350 assays spanning human, mouse, rat, and non-human primate. Just select your sample type, cartridge size (16, 32, or 72 samples), and add up to 8 analytes per cartridge.
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, IHC, Block, ICC |
| Reactivity: | Human, Mouse, Canine, Bovine |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ICC/IF, Func, KO, +1 More |
![Knockout Validated: LDLR Antibody - BSA Free [NBP1-06709]](https://resources.bio-techne.com/images/products/LDLR-Antibody-Knockout-Validated-NBP1-06709-img0009.jpg "Western Blot: LDLR Antibody - BSA Free [NBP1-06709]")
| Reactivity: | Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Flow, IHC, Block, CyTOF-ready |
![Western Blot: LDLR Overexpression Lysate [NBL1-12475]](https://resources.bio-techne.com/images/products/LDL-Receptor-Overexpression-Lysate-Adult-Normal-Western-Blot-NBL1-12475-img0002.jpg "Western Blot: LDLR Overexpression Lysate [NBL1-12475]")
| Source: | NS0 |
| Accession #: | P01130 |
| Applications: | BA |
Luminex High Performance Assays go through rigorous development, validation, and quality control testing to ensure you are getting the best performance out of your multiplex assay. Panels are customizable so you can order a selection of the analytes or the entire panel.
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #472413 |
| Applications: | Flow |
| Sensitivity: | 10.3 pg/mL |
| Applications: | ELISA |
| Assay Range: | 62.5 - 4,000 pg/mL (Cell Culture Supernates, Cell Lysates, Serum, Heparin Plasma, Urine) |
| Reactivity: | Human, Mouse, Rat, Bovine, Porcine |
| Details: | Mouse IgG2B Monoclonal Clone #C7 |
| Applications: | IHC, WB, ELISA, ICC/IF, Flow, +3 More |
![Western Blot: LDLR Antibody (C7) [NBP1-78159]](https://resources.bio-techne.com/images/products/LDL-R-Antibody-C7-Western-Blot-NBP1-78159-img0008.jpg "Western Blot: LDLR Antibody (C7) [NBP1-78159]")
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #472413 |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Source: | HEK293 |
| Accession #: | XP_005588053.1 |
| Applications: | BA |
| Source: | NS0 |
| Accession #: | Q59FQ1 |
| Applications: | Bind |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, IHC, Block, ICC |
| Sensitivity: | 0.064 ng/mL |
| Applications: | ELISA |
| Assay Range: | 0.313 - 20 ng/mL (Cell Culture Supernates, Tissue Homogenates, Serum, EDTA Plasma, Heparin Plasma) |
| Assay Range: | 125 - 8,000 pg/mL |
| Applications: | ELISA |
| Reactivity: | Mouse |
| Details: | Rat IgG2a Monoclonal Clone #263123 |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #472413 |
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Monoclonal Clone #SJ0197 |
| Applications: | IHC, WB, ICC/IF, Flow |
![Western Blot: LDLR Antibody (SJ0197) [NBP2-67414]](https://resources.bio-techne.com/images/products/LDLR-Antibody-SJ0197-Western-Blot-NBP2-67414-img0008.jpg "Western Blot: LDLR Antibody (SJ0197) [NBP2-67414]")