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IL-12 R beta 2 Products

The biological activities of IL-12 are mediated through a receptor complex composed of two class I cytokine receptor subunits designated IL-12 R beta 1 and IL-12 R beta 2. Both subunits are required for high-affinity binding and activity of IL-12. IL-12 R beta 1 binds specifically to IL-12 p40, a subunit of the heterodimeric IL-12, and is also a subunit of the IL-23 receptor complex, while IL-12 R beta 2 binds IL-12 p35. IL-12 Rs are predominantly expressed on NK cells and activated T (Th1) cells with some expression also on dendritic cells. Both IL-12 R subunit extracellular domains are composed of three fibronectin-like domains and two cytokine receptor homology domains. IL-12R beta 2 also has an extracellular Ig-like domain.

13 results for "IL-12 R beta 2" in Products

IL-12 R beta 2 Products

The biological activities of IL-12 are mediated through a receptor complex composed of two class I cytokine receptor subunits designated IL-12 R beta 1 and IL-12 R beta 2. Both subunits are required for high-affinity binding and activity of IL-12. IL-12 R beta 1 binds specifically to IL-12 p40, a subunit of the heterodimeric IL-12, and is also a subunit of the IL-23 receptor complex, while IL-12 R beta 2 binds IL-12 p35. IL-12 Rs are predominantly expressed on NK cells and activated T (Th1) cells with some expression also on dendritic cells. Both IL-12 R subunit extracellular domains are composed of three fibronectin-like domains and two cytokine receptor homology domains. IL-12R beta 2 also has an extracellular Ig-like domain.

13 results for "IL-12 R beta 2" in Products

BA
Catalog #: RDC1169
Catalog #: RDC1184
BA

Biotinylated

WB
Catalog #: AF1959
WB, Block
Block
WB
BA
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