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IkB Kinase Inhibitors: Small Molecules and Peptides

The classical active IKK complex, composed of IKK alpha, IKK beta, and two forms of processed IKK gamma, phosphorylates and inactivates IkB, resulting in the release and nuclear translocation of active NFkB. The regulatory IKK gamma is required for activation of the IKK complex. IKK epsilon is an IKK-related kinase with 30% structural homology to IKK alpha and beta, and is present in a subset of IKK complexes.

14 results for "IkB Kinase Inhibitors Small Molecules and Peptides" in Products

IkB Kinase Inhibitors: Small Molecules and Peptides

The classical active IKK complex, composed of IKK alpha, IKK beta, and two forms of processed IKK gamma, phosphorylates and inactivates IkB, resulting in the release and nuclear translocation of active NFkB. The regulatory IKK gamma is required for activation of the IKK complex. IKK epsilon is an IKK-related kinase with 30% structural homology to IKK alpha and beta, and is present in a subset of IKK complexes.

14 results for "IkB Kinase Inhibitors Small Molecules and Peptides" in Products

Selective inhibitor of TBK

Salt inducible kinase (SIK) inhibitor

Selective IKK inhibitor; orally active

Novel IKK2-selective inhibitor

Selective allosteric inhibitor of IKK; anti-inflammatory

Selective inhibitor of IKK

Inhibitor of IKKβ; also exhibits antibacterial activity

IKKβ inhibitor; attenuates NF-κB-induced gene expression

Potent and selective IKKε inhibitor

Nrf2 pathway activator; also NF-κB pathway inhibitor; inhibits IKKβ

Potent and selective IKKβ inhibitor

Selective IKKβ inhibitor

Selective IKKα and IKKβ inhibitor

Potent, selective inhibitor of IKKβ

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