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IkB Kinase Inhibitors: Small Molecules and Peptides
The classical active IKK complex, composed of IKK alpha, IKK beta, and two forms of processed IKK gamma, phosphorylates and inactivates IkB, resulting in the release and nuclear translocation of active NFkB. The regulatory IKK gamma is required for activation of the IKK complex. IKK epsilon is an IKK-related kinase with 30% structural homology to IKK alpha and beta, and is present in a subset of IKK complexes.
14 results for "IkB Kinase Inhibitors Small Molecules and Peptides" in Products
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IkB Kinase Inhibitors: Small Molecules and Peptides
The classical active IKK complex, composed of IKK alpha, IKK beta, and two forms of processed IKK gamma, phosphorylates and inactivates IkB, resulting in the release and nuclear translocation of active NFkB. The regulatory IKK gamma is required for activation of the IKK complex. IKK epsilon is an IKK-related kinase with 30% structural homology to IKK alpha and beta, and is present in a subset of IKK complexes.
14 results for "IkB Kinase Inhibitors Small Molecules and Peptides" in Products
Selective inhibitor of TBK
| Chemical Name : | 2-Amino-7-(1-methylethyl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid |
| Purity : | ≥99% (HPLC) |
Catalog #:
5134
Salt inducible kinase (SIK) inhibitor
| Chemical Name : | N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide dihydrochloride |
| Purity : | ≥98% (HPLC) |
Selective IKK inhibitor; orally active
| Chemical Name : | N-(6-Chloro-9H-pyrido[3,4-b]indol-8-yl)-3-pyridinecarboxamide dihydrochloride |
| Purity : | ≥98% (HPLC) |
Novel IKK2-selective inhibitor
| Chemical Name : | N-(6-Chloro-7-methoxy-9H-pyrido[3,4-b]indol-8-yl)-2-methyl-3-pyridinecarboxamide dihydrochloride |
| Purity : | ≥98% (HPLC) |
Selective allosteric inhibitor of IKK; anti-inflammatory
| Chemical Name : | N1-(1,8-Dimethylimidazo[1,2-a]quinoxalin-4-yl)-1,2-ethanediamine hydrochloride |
| Purity : | ≥99% (HPLC) |
Selective inhibitor of IKK
| Chemical Name : | N-(4-Pyrrolidin-1-yl-piperidin-1-yl)-[4-(4-benzo[b]thiophen-2-yl-pyrimidin-2-ylamino)phenyl]carboxamide hydrochloride |
| Purity : | ≥98% (HPLC) |
Inhibitor of IKKβ; also exhibits antibacterial activity
| Chemical Name : | N-[3,5-Bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide |
| Purity : | ≥99% (HPLC) |
IKKβ inhibitor; attenuates NF-κB-induced gene expression
| Chemical Name : | 4-Amino-[2',3'-bithiophene]-5-carboxamide |
| Purity : | ≥98% (HPLC) |
Catalog #:
5672
Potent and selective IKKε inhibitor
| Chemical Name : | 5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-[[2-(methylsulfonyl)phenyl]methoxy]-2-thiophenecarbonitrile |
| Purity : | ≥98% (HPLC) |
Catalog #:
6646
Nrf2 pathway activator; also NF-κB pathway inhibitor; inhibits IKKβ
| Chemical Name : | 2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid methyl ester |
Potent and selective IKKβ inhibitor
| Chemical Name : | 8-[[[5-Chloro-2-[3,4-dimethyl-3,4-bis(hydroxymethyl)-1-pyrrolidinyl]-4-pyridinyl]carbonyl]amino]-1-(4-fluorophenyl)-4,5-dihydro-1H-benz[g]indazole-3-carboxamide |
| Purity : | ≥98% (HPLC) |
Selective IKKβ inhibitor
| Chemical Name : | 3-Amino-4-(1,1-difluoropropyl)-6-[4-(methylsulfonyl)-1-piperidinyl]thieno[2,3-b]pyridine-2-carboxamide |
| Purity : | ≥98% (HPLC) |
Selective IKKα and IKKβ inhibitor
| Chemical Name : | 2-Amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile |
| Purity : | ≥97% (HPLC) |
Potent, selective inhibitor of IKKβ
| Chemical Name : | 2-[(Aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide |
| Purity : | ≥97% (HPLC) |
