6 results for "Glutathione Peroxidase 4/GPX4 Small Molecules and Peptides" in Products
Glutathione Peroxidase 4/GPX4: Small Molecules and Peptides
Glutathione Peroxidase 4 (GPX4; also known as PHGPx) is a monomeric, 21 kDa member of the glutathione peroxidase family of proteins. It is widely expressed and serves to both protect cell membranes from phospholipid and cholesterol hydroperoxidases, and form an inactive enzyme structural component of the sperm mitochondrial capsule. Human GPX4 is 197 amino acids (aa) in length and contains a mitochondrial targeting sequence (aa 1-27) and an enzymatically active selenocysteine at Sec73. During ...
Inhibits glutathione peroxidase (GPX4); induces ferroptosis
| Chemical Name: | (1S,3R)-Methyl 2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methoxycarbonyl)phenyl]-1H-pyrido[3,4-b]indole-3-carboxylate |
| Purity: | ≥98% (HPLC) |
Inhibits glutathione peroxidase (GPX4); induces ferroptosis
| Chemical Name: | 2-[(Chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide |
| Purity: | ≥98% (HPLC) |
Selectively kills mutant HRAS-expressing cells; glutathione peroxidase inhibitor; induces ferroptosis
| Chemical Name: | [4-[Bis(4-chlorophenyl)methyl]-1-piperazinyl](5-methyl-4-nitro-3-isoxazolyl)methanone |
| Purity: | ≥98% (HPLC) |
Potent ferroptosis inhibitor
| Chemical Name: | N-[(3-Chlorophenyl)methyl]spiro[piperidine-4,2'(1'H)-quinoxalin]-3'-amine hydrochloride |
| Purity: | ≥98% (HPLC) |
Negative control for 1S,3R-RSL3 (Cat. No. 6118)
| Chemical Name: | (1R,3R)-Methyl 2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methoxycarbonyl)phenyl]-1H-pyrido[3,4-b]indole-3-carboxylate |
| Purity: | ≥98% (HPLC) |
Ferroptosis activator
| Chemical Name: | N2,N7-Dicyclohexyl-9-(hydroxyimino)-9H-fluorene-2,7-disulfonamide |
| Purity: | ≥98% (HPLC) |
