1S,3R-RSL3
Tocris Bioscience, part of Bio-Techne | Catalog # 6118
Inhibits glutathione peroxidase (GPX4); induces ferroptosis
Key Product Details
Description
Inhibits glutathione peroxidase (GPX4); induces ferroptosis
Product Description
1S,3R-RSL3 is a glutathione peroxidase 4 (GPX4) inhibitor. Induces ferroptosis. Increases lipid peroxidase levels in vitro. Inhibits tumor formation and progression in vivo.Negative control 1R,3R-RSL3 (Cat. No. 6687) also available.
Licensing Information
Sold with the permission of Columbia University.Product Specifications
Molecular Weight
440.88
Formula
C23H21ClN2O5
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(1S,3R)-Methyl 2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methoxycarbonyl)phenyl]-1H-pyrido[3,4-b]indole-3-carboxylate
CAS Number
1219810-16-8
PubChem ID
16398939
InChI Key
TXJZRSRTYPUYRW-YMXDCFFPSA-N
SMILES
COC([C@H]1CC2=C([C@H](C3=CC=C(C(OC)=O)C=C3)N1C(CCl)=O)NC4=CC=CC=C24)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 44.09 | 100 |
Preparing Stock Solutions
for 1S,3R-RSL3
The following data is based on the product molecular weight 440.88
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.27 mL | 11.34 mL | 22.68 mL |
| 5 mM | 0.45 mL | 2.27 mL | 4.54 mL |
| 10 mM | 0.23 mL | 1.13 mL | 2.27 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.45 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Yang Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis. Proc.Natl.Acad.Sci.U.S.A. 2016 PMID: 27506793
- Feng & Stockwell Unsolved mysteries: How does lipid peroxidation cause ferroptosis? PLoS. Biol. 2018 PMID: 29795546
- Yang Regulation of ferroptotic cancer cell death by GPX4. Cell. 2014 PMID: 24439385
Product Specific Notices for 1S,3R-RSL3
For research use only
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