ML 162
Tocris Bioscience, part of Bio-Techne | Catalog # 7821
Inhibits glutathione peroxidase (GPX4); induces ferroptosis
Key Product Details
Description
Inhibits glutathione peroxidase (GPX4); induces ferroptosis
Product Description
ML 162 is a covalent glutathione peroxidase 4 (GPX4) inhibitor. It induces ferroptosis in vivo. It is selectively lethal to mutant RAS oncogene-expressing cell lines (IC50 = 25 and 578 nM for HRASG12V-expressing and wild-type BJ fibroblasts, respectively).Product Specifications
Molecular Weight
477.41
Formula
C23H22Cl2N2O3S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2-[(Chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide
CAS Number
1035072-16-2
PubChem ID
3689413
InChI Key
UNVKYJSNMVDZJE-UHFFFAOYSA-N
SMILES
O=C(NCCC=1C=CC=CC1)C(C=2SC=CC2)N(C(=O)CCl)C3=CC=C(OC)C(Cl)=C3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 47.74 | 100 | |
| Ethanol | 9.55 | 20 |
Preparing Stock Solutions
for ML 162
The following data is based on the product molecular weight 477.41
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.09 mL | 10.47 mL | 20.95 mL |
| 5 mM | 0.42 mL | 2.09 mL | 4.19 mL |
| 10 mM | 0.21 mL | 1.05 mL | 2.09 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.42 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Karaj Tunable cysteine-targeting electrophilic heteroaromatic warheads induce ferroptosis. J.Med.Chem. 2022 PMID: 35984756
- Weïwer Development of small-molecule probes that selectively kill cells induced to express mutant RAS. Bioorg.Med.Chem.Lett. 2012 PMID: 22297109
- Luo Intracellular delivery of glutathione peroxidase degrader induces ferroptosis in vivo. Angew.Chem.Int.Ed.Engl. 2022 PMID: 35924720
Product Specific Notices for ML 162
For research use only
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