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GDF-8/Myostatin Products
GDF-8/Myostatin is a secreted protein that is expressed in developing and adult skeletal muscle. It controls myoblast proliferation and is a potent negative regulator of skeletal muscle mass. It is upregulated in mechanically-stressed cardiomyocytes and induces the skeletal muscle wasting which is common in heart failure. The GDF-8 propeptide is cleaved from GDF-8 but remains associated and functions as an inhibitor of mature GDF-8. GDF-8 activity can also be inhibited through its association with Follistatin, FLRG, Decorin, or GASP-1. Active GDF-8 signals through a receptor complex containing Activin RIIB and either Activin RIB/ALK-4 or TGF-beta RI/ALK-5.
17 results for "GDF-8/Myostatin" in Products
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GDF-8/Myostatin Products
GDF-8/Myostatin is a secreted protein that is expressed in developing and adult skeletal muscle. It controls myoblast proliferation and is a potent negative regulator of skeletal muscle mass. It is upregulated in mechanically-stressed cardiomyocytes and induces the skeletal muscle wasting which is common in heart failure. The GDF-8 propeptide is cleaved from GDF-8 but remains associated and functions as an inhibitor of mature GDF-8. GDF-8 activity can also be inhibited through its association with Follistatin, FLRG, Decorin, or GASP-1. Active GDF-8 signals through a receptor complex containing Activin RIIB and either Activin RIB/ALK-4 or TGF-beta RI/ALK-5.
17 results for "GDF-8/Myostatin" in Products
| Sensitivity : | 5.32 pg/mL |
| Assay Range : | 31.3 - 2,000 pg/mL (Cell Culture Supernates, Tissue Homogenates, Serum, EDTA Plasma, Heparin Plasma) |
| Applications : | ELISA |
| Source : | NS0 |
| Accession # : | O08689 |
| Applications : | Bioactivity |
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| Source : | NS0 |
| Accession # : | O08689.1 |
| Applications : | Bioactivity |
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | Block/Neutralize, Immunohistochemistry, Western Blot |
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | Immunohistochemistry, Western Blot |
| Clonality : | Polyclonal |
| Host : | Sheep IgG |
| Applications : | Block/Neutralize, Western Blot |
| Assay Range : | 31.2 - 2,000 pg/mL |
| Applications : | ELISA |
| Clonality : | Monoclonal |
| Host : | Rat IgG2b Clone #84231 |
| Applications : | Western Blot |
| Clonality : | Polyclonal |
| Host : | Sheep IgG |
| Applications : | Western Blot |
| Source : | NS0 |
| Accession # : | NP_034964 |
| Applications : | Bioactivity |
| Source : | NS0 |
| Accession # : | O08689 |
| Applications : | Bioactivity |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #743835 |
| Applications : | Block/Neutralize, ELISA |
| Clonality : | Monoclonal |
| Host : | Rat IgG2b Clone #84214 |
| Applications : | Western Blot |
Recombinant Monoclonal Antibody.
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #743835R |
| Applications : | Block/Neutralize, ELISA |
