GDF-8/Myostatin Products
GDF-8/Myostatin is a secreted protein that is expressed in developing and adult skeletal muscle. It controls myoblast proliferation and is a potent negative regulator of skeletal muscle mass. It is upregulated in mechanically-stressed cardiomyocytes and induces the skeletal muscle wasting which is common in heart failure. The GDF-8 propeptide is cleaved from GDF-8 but remains associated and functions as an inhibitor of mature GDF-8. GDF-8 activity can also be inhibited through its association with Follistatin, FLRG, Decorin, or GASP-1. Active GDF-8 signals through a receptor complex containing Activin RIIB and either Activin RIB/ALK-4 or TGF-beta RI/ALK-5.
17 results for "GDF-8/Myostatin" in Products
Search
Application
Conjugates
Clonality
Host Species
Isotype
Clone
Low Endotoxin
Sample Size
Citations
Reviews
GDF-8/Myostatin Products
GDF-8/Myostatin is a secreted protein that is expressed in developing and adult skeletal muscle. It controls myoblast proliferation and is a potent negative regulator of skeletal muscle mass. It is upregulated in mechanically-stressed cardiomyocytes and induces the skeletal muscle wasting which is common in heart failure. The GDF-8 propeptide is cleaved from GDF-8 but remains associated and functions as an inhibitor of mature GDF-8. GDF-8 activity can also be inhibited through its association with Follistatin, FLRG, Decorin, or GASP-1. Active GDF-8 signals through a receptor complex containing Activin RIIB and either Activin RIB/ALK-4 or TGF-beta RI/ALK-5.
17 results for "GDF-8/Myostatin" in Products
Sensitivity : | 5.32 pg/mL |
Assay Range : | 31.3 - 2,000 pg/mL (Cell Culture Supernates, Tissue Homogenates, Serum, EDTA Plasma, Heparin Plasma) |
Applications : | ELISA |
Source : | NS0 |
Accession # : | O08689 |
Applications : | Bioactivity |
Earn double rewards for reviews
Source : | NS0 |
Accession # : | O08689.1 |
Applications : | Bioactivity |
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | Block/Neutralize, Immunohistochemistry, Western Blot |
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | Immunohistochemistry, Western Blot |
Clonality : | Polyclonal |
Host : | Sheep IgG |
Applications : | Block/Neutralize, Western Blot |
Assay Range : | 31.2 - 2,000 pg/mL |
Applications : | ELISA |
Clonality : | Monoclonal |
Host : | Rat IgG2b Clone #84231 |
Applications : | Western Blot |
Clonality : | Polyclonal |
Host : | Sheep IgG |
Applications : | Western Blot |
Source : | NS0 |
Accession # : | NP_034964 |
Applications : | Bioactivity |
Source : | NS0 |
Accession # : | O08689 |
Applications : | Bioactivity |
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #743835 |
Applications : | Block/Neutralize, ELISA |
Clonality : | Monoclonal |
Host : | Rat IgG2b Clone #84214 |
Applications : | Western Blot |
Recombinant Monoclonal Antibody.
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #743835R |
Applications : | Block/Neutralize, ELISA |