Recombinant Human/Mouse/Rat GDF-8/Myostatin Protein Best Seller
Catalog # 788-G8 | R&D Systems, Inc. a Bio-Techne Brand
Key Product Details
Source: | NS0 |
Accession #: | O08689 |
Structure / Form: | Disulfide-linked homodimer |
Applications: | Bioactivity |
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Citations for Recombinant Human/Mouse/Rat GDF-8/Myostatin Protein (40)
Citations are publications that use Bio-Techne products. Selected citations for Recombinant Human/Mouse/Rat GDF-8/Myostatin Protein include:
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Species: Human
Sample Types: Transfected Whole Cells
Applications: BioassayR Mishra et al. (2022-10-06), Maternal immunization against myostatin suppresses post-hatch chicken growth PLoS ONE, 2022-117(10):e0275753.
PMID: 36201511 -
Species: Mouse
Sample Types: Serum
Applications: ELISA CaptureDK Sung et al. (2022-08-13), A New Method of Myostatin Inhibition in Mice via Oral Administration of Lactobacillus casei Expressing Modified Myostatin Protein, BLS-M22 International Journal of Molecular Sciences, 2022-023(16).
PMID: 36012334 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayA Hagg et al. (2020-11-04), TMEPAI/PMEPA1 Is a Positive Regulator of Skeletal Muscle Mass Front Physiol, 2020-111(0):560225.
PMID: 33250771 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayYC Chang et al. (2020-07-22), The green tea polyphenol epigallocatechin-3-gallate attenuates age-associated muscle loss via regulation of miR-486-5p and myostatin Arch. Biochem. Biophys., 2020-0692(0):108511.
PMID: 32710883 -
Species: Mouse
Sample Types: In Vivo, Whole Cells
Applications: Cell Culture, In VivoEAC Goossens et al. (2020-05-15), Myostatin Inhibits Vascular Smooth Muscle Cell Proliferation and Local 14q32 microRNA Expression, But Not Systemic Inflammation or Restenosis Int J Mol Sci, 2020-021(10).
PMID: 32429150 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayM Kodaka et al. (2020-04-08), Characterization of a novel compound that promotes myogenesis via�Akt and transcriptional co-activator with PDZ-binding motif (TAZ) in mouse C2C12 cells PLoS ONE, 2020-015(4):e0231265.
PMID: 32267872 -
Species: Human
Sample Types: Cell Culture Supernates
KB Dagbay et al. (2020-02-19), Structural basis of specific inhibition of extracellular activation of pro- or latent myostatin by the monoclonal antibody SRK-015 J. Biol. Chem., 2020-0295(16):5404-5418.
PMID: 32075906 -
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay, Cell CultureXH Liu et al. (2019-08-01), AdipoRon prevents myostatin-induced upregulation of fatty acid synthesis and downregulation of insulin activity in a mouse hepatocyte line Physiol Rep, 2019-07(13):e14152.
PMID: 31250564 -
Species: Human
Sample Types: Cell Lysates
Applications: BioassayQ Jin et al. (2019-05-27), A GDF11/myostatin inhibitor, GDF11 propeptide-Fc, increases skeletal muscle mass and improves muscle strength in dystrophic mdx mice Skelet Muscle, 2019-09(1):16.
PMID: 31133057 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayJH Kim et al. (2019-04-18), Identification of the minimum region of flatfish myostatin propeptide (Pep45-65) for myostatin inhibition and its potential to enhance muscle growth and performance in animals PLoS ONE, 2019-014(4):e0215298.
PMID: 30998775 -
Species: Porcine
Sample Types: Whole Tissue
Applications: BioassayJD Yoon et al. (2019-02-13), GDF8 enhances SOX2 expression and blastocyst total cell number in porcine IVF embryo development Theriogenology, 2019-0129(0):70-76.
PMID: 30825707 -
Species: Mouse
Sample Types: Serum
A Iskenderia et al. (2018-10-27), Myostatin and activin blockade by engineered follistatin results in hypertrophy and improves dystrophic pathology in mdx mouse more than myostatin blockade alone Skelet Muscle, 2018-18(1):34.
PMID: 30368252 -
Species: Mouse
Sample Types: In Vivo
Applications: In VivoKM Estrellas et al. (2018-08-23), Biological scaffold-mediated delivery of myostatin inhibitor promotes a regenerative immune response in an animal model of Duchenne muscular dystrophy J. Biol. Chem., 2018-00(0).
PMID: 30139748 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassaySJ Lessard et al. (2018-08-02), JNK regulates muscle remodeling via myostatin/SMAD inhibition Nat Commun, 2018-09(1):3030.
PMID: 30072727 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayL Formicola et al. (2018-05-24), Inhibition of the Activin Receptor Type-2B Pathway Restores Regenerative Capacity in Satellite Cell-Depleted Skeletal Muscle Front Physiol, 2018-09(0):515.
PMID: 29881353 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayLF Wu et al. (2017-12-16), Relative abundance of mature myostatin rather than total myostatin is negatively associated with bone mineral density in Chinese J. Cell. Mol. Med., 2017-10(0).
PMID: 29247983 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassaySA Samant et al. (2017-09-19), The histone deacetylase SIRT6 blocks myostatin expression and development of muscle atrophy Sci Rep, 2017-07(1):11877.
PMID: 28928419 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayJL Chen et al. (2017-06-12), Specific targeting of TGF-? family ligands demonstrates distinct roles in the regulation of muscle mass in health and disease Proc. Natl. Acad. Sci. U.S.A., 2017-00(0).
PMID: 28607086 -
Species: Human
Sample Types: Recombinant Protein
Applications: Surface Plasmon ResonanceE Latres et al. (2017-04-28), Activin A more prominently regulates muscle mass in primates than does GDF8 Nat Commun, 2017-08(0):15153.
PMID: 28452368 -
Species: Rat
Sample Types: Serum
Applications: BioassayY Zhao et al. (2017-04-26), A multiplexed immunocapture liquid chromatography tandem mass spectrometry assay for the simultaneous measurement of myostatin and GDF-11 in rat serum using an automated sample preparation platform Anal. Chim. Acta, 2017-0979(0):36-44.
PMID: 28599707 -
Species: Human
Sample Types: Whole Cells
Applications: BioassaySB Lee et al. (2017-04-03), Maltose binding protein-fusion enhances the bioactivity of truncated forms of pig myostatin propeptide produced in E. coli PLoS ONE, 2017-012(4):e0174956.
PMID: 28369115 -
Species: Human, Mouse
Sample Types: Whole Cells
Applications: BioassayDW Hammers et al. (2017-04-01), Supraphysiological levels of GDF11 induce striated muscle atrophy EMBO Mol Med, 2017-00(0).
PMID: 28270449 -
Species: Human, Mouse
Sample Types: In Vivo, Whole Cells
Applications: Bioassay, In VivoRG Walker et al. (2017-03-03), Structural basis for potency differences between GDF8 and GDF11 BMC Biol, 2017-015(1):19.
PMID: 28257634 -
Applications: ControlTamas Kocsis (2016-12-13), Myostatin propeptide mutation of the hypermuscular Compact mice decreases the formation of myostatin and improves insulin sensitivity Am. J. Physiol. Endocrinol. Metab, 2016-10(0):ajpendo.00216.
PMID: 27965203 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayLatres E et al. (2015-10-09), Myostatin blockade with a fully human monoclonal antibody induces muscle hypertrophy and reverses muscle atrophy in young and aged mice. Skelet Muscle, 2015-15(0):34.
PMID: 26457176 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassaySeto D et al. (2015-06-19), A Key Role for Leukemia Inhibitory Factor in C26 Cancer Cachexia. J Biol Chem, 2015-0290(32):19976-86.
PMID: 26092726 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayHorbelt D et al. (2014-11-03), Small molecules dorsomorphin and LDN-193189 inhibit myostatin/GDF8 signaling and promote functional myoblast differentiation. J Biol Chem, 2014-1290(6):3390-404.
PMID: 25368322 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayRelizani K et al. (2014-05-27), Blockade of ActRIIB signaling triggers muscle fatigability and metabolic myopathy. Mol Ther, 2014-022(8):1423-33.
PMID: 24861054 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayBiesemann N et al. (2014-05-07), Myostatin regulates energy homeostasis in the heart and prevents heart failure. Circ Res, 2014-0115(2):296-310.
PMID: 24807786 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayYang et al. (2014-02-18), Screening with a novel cell-based assay for TAZ activators identifies a compound that enhances myogenesis in C2C12 cells and facilitates muscle repair in a muscle injury model. Mol Cell Biol, 2014-034(9):1607-21.
PMID: 24550007 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayRodgers B et al. (2014-01-01), Myostatin stimulates, not inihibits, C2C12 myoblast proliferation. Endocrinology, 2014-0155(3):670-5.
PMID: 24424069 -
Species: Human
Sample Types: Whole Cells
Applications: Cell CultureSneddon et al. (2012-10-07), Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme. Nature, 2012-1491(7426):765-8.
PMID: 23041930 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayWilson TR et al. (2012-07-26), Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature, 2012-0487(7408):505-9.
PMID: 22763448 -
Sample Types: N/A
Applications: ELISA (Standard)Diel P et al. (2010-08-27), Analysis of the effects of androgens and training on myostatin propeptide and follistatin concentrations in blood and skeletal muscle using highly sensitive Immuno PCR. Mol. Cell. Endocrinol., 2010-0330(1):1-9.
PMID: 20801187 -
Species: Mouse
Sample Types: In Vivo
Applications: In VivoWilkes JJ et al. (2009-02-10), Loss-of-function mutation in myostatin reduces tumor necrosis factor alpha production and protects liver against obesity-induced insulin resistance. Diabetes, 2009-058(5):1133-43.
PMID: 19208906 -
Species: Human
Sample Types: Recombinant Protein
Applications: ELISA Developmet, Surface Plasmon ResonanceSengle G et al. (2008-07-02), A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7. J. Mol. Biol., 2008-0381(4):1025-39.
PMID: 18621057 -
Species: Human
Sample Types: Recombinant Protein
Applications: Binding Assay, Surface Plasmon ResonanceSengle G et al. (2008-03-13), Targeting of bone morphogenetic protein growth factor complexes to fibrillin. J. Biol. Chem., 2008-0283(20):13874-88.
PMID: 18339631 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayMiller TM et al. (2006-12-12), Gene transfer demonstrates that muscle is not a primary target for non-cell-autonomous toxicity in familial amyotrophic lateral sclerosis. Proc. Natl. Acad. Sci. U.S.A., 2006-1103(51):19546-51.
PMID: 17164329 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayOhsawa Y et al. (2006-10-12), Muscular atrophy of caveolin-3-deficient mice is rescued by myostatin inhibition. J. Clin. Invest., 2006-1116(11):2924-34.
PMID: 17039257 -
Species: Chicken
Sample Types: Whole Tissue
Applications: BioassayAmthor H et al. (2004-06-01), Follistatin complexes Myostatin and antagonises Myostatin-mediated inhibition of myogenesis. Dev. Biol., 2004-0270(1):19-30.
PMID: 15136138
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Customer Reviews for Recombinant Human/Mouse/Rat GDF-8/Myostatin Protein (2)
Customer Images
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Application: In vitro bioactivity in cell cultureVerified Customer | Posted 04/07/2020
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Application: Immunoassay StandardVerified Customer | Posted 10/20/2017
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FAQs for Recombinant Human/Mouse/Rat GDF-8/Myostatin Protein
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Is Recombinant Human/Mouse/Rat GDF-8/Myostatin Protein (Catalog # 788-G8) the mature form of GDF8?
The mature form of GDF8 consists of a disulfide-linked homodimer. Catalog 788-G8 consists of Asp268-Ser376. There are multiple disulfide bonds within this sequence, which form a disulfide-linked heterodimer with another Asp268-Ser376 molecule.